Infections

Question 1

Tx for HSV?

Answer 1

Acyclovir
Valacyclovir
Famcyclovir/Foscarnet

Question 2

Tx for Syphilis?

Answer 2

Penicillin G

Question 3

Tx for Chlamydia?

Answer 3

Azithromycin
Doxycycline
Erythromycin
Levofloxacin/Ofloxain
Amoxicillin

Question 4

Tx for Chancroid?

Answer 4

Azythromycin?Erythromycin
Cerftriaxone
Ciprofloxacin

Question 5

Tx for Gonorhea?

Answer 5

Genital: 
   Cefriaxone
   Axithromycin
   Doxy
   Cefixime
Pharyngeal:
   no cefixime

Question 6

Tx for Trichomonas?

Answer 6

Metronidazole/Tinidazole

Question 7

Tx for Urethritis?

Answer 7

Acute:
   Azithromycin
   Doxy
   Erythromycine
   Levofloxacin/Ofloxacin
Recurrent:
   Metronidazole/tinidazole
   Azithromycin

Question 8

Tx for bacterial vaginitis?

Answer 8

Type:

fungal: azole
trich: metronidazole
bacterial: clindamycin

Question 9

Tx for candidiasis?

Answer 9

Azoles

Question 10

Tx for HPV?

Answer 10

Gardasil
Cervarix
Podofilox
Imiquimod
Sinecatechins

Question 11

Acyclovir MOA/AE?

Answer 11

Guanasine analog
Competes for deoxyGTP
Inhibits viral DNA polymerase
Needs TK activation: adds 1st of 3 phosphates

AE:
Renal crystaliasis
Neurotoxic: seizures
Cross reactivity HS

Question 12

Famcyclovir MOA/AE?

Answer 12

Not TK needed
guanosine analog like acyclovir

AE;
second line
no neurotoxicity
liver metabolism to penciclovir

Question 13

Penicillin MOA/AE?

Answer 13

PBP

HS

Question 14

Azithromycin MOA/AE?

Answer 14

MOA: static
50s ribosomal subunit
prevent peptidyl-transferase from adding AA

AE:
inactivated by gastric acid
GI upset
vaginitis

Question 15

Doxycycoline MOA/AE?

Answer 15

MOA: static
30S

AE:
    cat D drug: not in pregnancy (teeth!)
    GI
    Hepatic damage in pregnancy
    Photosensitivity
    Discoloration

Question 16

Levofloxacin MOA/AE?

Answer 16

MOA: cidal
G- block DNA gyrase
G+ block topo4

AE: 
     Taste disturbance
     GI
     BBW: tendon rupture
     muscle weakness: avoid in myasthenia gravis
     Cat C: animal studies

Question 17

Ceftriaxone MOA/AE?

Answer 17

MOA: cidal
PBP: fancy beta lactam: lysis

AE:
     Does not cross placenta
     Breastfed baby has diarrhea: breast milk
     candidiasis
     rash

Question 18

Metronidazole MOA/AE?

Answer 18

MOA: cidal for everything
disrupts DNA helix after uptake into bugs
dividing and non dividing cells effected

AE: 
   Avoid in pregnancy/breastfeeding (DNA!!)
    *Disulfiram: alcohol makes nausea!
    *Secondary malignancy
    GI
    Candidiasis

Question 19

Clindamycin MOA/AE?

Answer 19

MOA: static
50S

AE: intravaginal only!
     1st trimester only: 
           low weight
           pre term
           PROM-->neonatal infections
    Breast milk excretion
     GI upset
    contact dermatitis

Question 20

Azoles MOA/AE?

Answer 20

MOA:
14alpha demethylase CYP
prevent lanosterol to ergosterol synthesis

AE:
    Cat X: cleft palate, abdominal wall
     maternal stress (avoid 1st trimester)
     Break condoms/diaphragms

Question 21

Gardasil coverage?

Answer 21

6,11,16,18: warts and cancer

Question 22

Cervarix coverage?

Answer 22

16,18: cancer only (Cervarix=C=Cancer only)