Outcome 3 - Learning And Memory Flashcards
Differences between neurotransmitters and neurohormones
Neurotransmitters are chemicals released by the presynaptic neuron and are released directly into the synapse. They can only effect other Neurons if the they are linked via a synapse. Carry messages short distances (from pre to post synaptic neuron) the effect is quick,
Neurohormones are released by a pre synaptic neuron, and directly into the bloodstream. Carey messages throughout the body, often to distant sites (organs) travel further than hormones. The effect that they produce is not as fast as neurotransmitters
Synaptic plasticity
Describes the changes that occur to synapse, it can lead to an increase or decrease in activity. It is when the number of receptor sites on the post synaptic neuron changes, and increase or decrease in the amount of neurotransmitter in the per synaptic neuron or other structural changes. This process is involved in LTP and LTD, providing a flexible functioning nervous system . (Learning and memory in the hippocampus)
Learning
Relatively permanent change in behaviour due to experience
Memory
An active information system the receives, organises, stores and recovers information when we need it
Simple systems approach
Using simplistic organisms to study the brain, an example of this is kandels experiment using aplysia (sea slugs). Which has simple neural circuits and any behavioural changes as a result of learning can be examined neuron by neurone
Kandels experiment
Physiological basis of memory - memory formation of neurons.
Using aplysia which have simple nervous systems and a small number of large and pigmented nerve cells.
By noting the changes in the levels of neurotransmitters released at the synapse he concluded that memory formation depends on neuronal activity. Increase of neurotransmitters = more efficient transmissions = more efficient neural circuits/ LTP
Alcohols effect on learning
Disrupts neurotransmitter levels (serotonin) = trouble remembering information
Synaptogenisis
Neurons developing new connections and forming new synapses or existing pathways are strengthened.
Info passes from neuron to neuron, if this happens repeatedly learning occurs.
Dendrites and axons project out and link with a target cell or form a synapse.
It also includes the pruning away of unused or unnecessary neurons
When does synaptogenesis occur
2 months before birth to 2 years rapidly and in puberty
Throughout a healthy persons lifespan
Hebb principals
Use it or loose it
- use of a function increases neural structure while disuse decreases it
- those that fire together are activated together wire together and in doing so form a synapse
Cerebellum
Brain structure involved in the memory of learnt skills and actions
Enriched vs deprived environments
Enriched environments
- greater synapse development, more dendrites (thicker cortices)
Than rats raised in deprived environments
Neural plasticity and in what what ways does it occur
Umbrella term used to describe the ability of the brain and nervous system to adapt to changing conditions, reorganise neural pathways, repair damaged ones or create new pathways.
- modifying the strength or efficiency or effectiveness of synaptic transmissions of excising synaptic connections
- producing growth of new synaptic connections or pruning away of exisiting ones
- modulating the excitability properties of individual neurons.
Factors that effect plasticity
Genetic factors
- specific traits and characteristics, encoded in our genes that we inherit from our parents
Environmental factors
- the amount of simulation our nervous system receives
Excitatory or inhibitory
Glutamate
- excitatory
GABA
- inhibitory
Depends on the type of neurotransmitter released by the presynaptic neuron and the ion channel receptors on the post synaptic neuron they interact with
What is LTP
Long term potentiation
A form of neural plasticity that is dependant on the activity between two neurons. That lead to an increase in the efficacy of synaptic transmission. Long lasting strengthening of two synaptic transmissions between neurons making them more likely to fire when subjected to a smaller amount of energy. Changes to the effectiveness of synaptic transmission
Where does LTP take place in the brain
In the temporal lobes, particularly in the hippocampus. (Memory consolidation) in the dendate gyrus.
Role of LTP on the post synaptic neuron
Na ions enter cell depolarising the pre synaptic neuron, causing a positive charge which simulates an action potential
This causes ca channels to open, which causes a chain of events causing vesicles to release neurotransmitters across the synapse
What are two important receptors involved in LTP and where are they found
On the post synaptic neuron
AMPA and NMDA
LTP on post synaptic neuron
Glutamate binds to AMPA receptors
Na ions pass through depolarising the cell
Causing NMDA receptors to be opened ( due to na ions forcing mg ions blocking the NMDA receptors to leave cell)
Ca enters NMDA receptors and binds to kinase (enzyme)
Kinase produces a phosphate group which binds to the AMPA increasing the sensitivity of the cell
At first this process requires a large and intense signal or large release of glutamate, but as learning occurs this can be achieved by a smaller signal or amount of glutamate to simulate post synaptic neuron