OUD-Naloxone Flashcards
What does mu receptor do?
ANALGESIA, euphoria, dependence, resp depression, gi issues
What does delta receptor do?
analgesia, euphoria, dependence
What does kappa receptor do?
not dependence
Some people that take opioids legitametly sometimes qualify for the disorder. DO they actually have it?
NO
How long is OUD treated for?
LONG TERM CHRONIC THERAPY
What are the 3 stages of addiction?
Binge/intoxication= consumes and gets pleasure
Withdrawal/negative affect= negative state in absence of substance
Preoccupation/anticipation= seeks drug
What happens to the cycle over time?
intensifies and greater harm
What part of brain handles reward?
mesolimbic in VTA area releases dopamine
What part of brain handles drive to get substance?
prefrontal to VTA= get tolerance and need more
How does drowsy and resp depression occur?
mu in LC= suppressed NoreE
MOA of naloxone
displaces opioid (antagonist)
How quick does naloxone fix breathing issues?
2-5 min
Issue of naloxone
can cause withdrawal/ overdose can return after 30-90 min
sx of opioid withdrawal?
vomit, urine, cramp, cramps, kicking legs, sweat
Is opioid withdrawal life threatening?
NO
