OUD-Naloxone Flashcards
What does mu receptor do?
ANALGESIA, euphoria, dependence, resp depression, gi issues
What does delta receptor do?
analgesia, euphoria, dependence
What does kappa receptor do?
not dependence
Some people that take opioids legitametly sometimes qualify for the disorder. DO they actually have it?
NO
How long is OUD treated for?
LONG TERM CHRONIC THERAPY
What are the 3 stages of addiction?
Binge/intoxication= consumes and gets pleasure
Withdrawal/negative affect= negative state in absence of substance
Preoccupation/anticipation= seeks drug
What happens to the cycle over time?
intensifies and greater harm
What part of brain handles reward?
mesolimbic in VTA area releases dopamine
What part of brain handles drive to get substance?
prefrontal to VTA= get tolerance and need more
How does drowsy and resp depression occur?
mu in LC= suppressed NoreE
MOA of naloxone
displaces opioid (antagonist)
How quick does naloxone fix breathing issues?
2-5 min
Issue of naloxone
can cause withdrawal/ overdose can return after 30-90 min
sx of opioid withdrawal?
vomit, urine, cramp, cramps, kicking legs, sweat
Is opioid withdrawal life threatening?
NO
How can we help with withdrawal?
NSAID for pain
laxative/loperimide for bowel
Dimenhydrinate fior nausea
Hydroxizine for anxiety/insomnia
clonidine for physical withdrawal
oxybutinin for sweating
Signs of opioid overdose
drowsy
blue lips/nails
small pupils
clammy
confused
choking
low breathing
What form of opioids is higher risk of OD?
INject
What do you do if you come across overdosing on opioid?
Try to wake them
call 911
recovery position
open airway
ventilate
evaluate
naloxone
