Otitis externa Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Ear physiology

A
  • Temp 38.2–38.4 ˚C
  • Humidity 88.5%
  • pH 6.1/6.2
  • Otitis associated with rise in temp, humidity and pH
  • Sebaceous glands
  • Ceruminous glands
  • Lipids + sloughed keratinocytes form cerumen
    – Cerumen traps small FB
    – Anti-bacterial/yeast
    – Epithelial migration moves wax from TM to the external space
    – Epithelial migration disturbed by inflammation, wetness, hyperplasia and physical blockage
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Normal flora in ear canal

A
  • Gram +ve cocci predominate (but no growth in some dog’s ears)
  • Similar species to those found on the skin
  • Micrococcus spp.
  • Coagulase negative staphylococci, Staphylococcus schleiferi and Staphylococcus pseudintermedius
  • Streptococcus species
  • Malassezia and many others
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Factors causing microbial overgrowth (or dysbiosis)

A
  • Humidity
  • Inflammation (and swelling)
  • Reduced epithelial migration
  • Epithelial surface changes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Most common organisms causing microbial overgrowth/dysbiosis

A
  • Staphylococcus pseudintermedius
  • Malassezia pachydermatis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

In treating otitis it is useful to consider PSPP(P)

A
  • Primary disease
    – e.g. atopic dermatitis, Otodectes cyanotis
  • Secondary disease
    – e.g. Malassezia, Staphylococci & Pseudomonas spp.
  • Predisposing factors
    – e.g. Hairy &/or pendulous ears, stenosis
  • Perpetuating factors
    – e.g. Ear canal hyperplasia, stenosis and scarring

(-Pain
– Very common
– Difficult to manage in face of steroids
– Results in difficulty in examination, subsequent behavioural problems at the vets
- Needs addressing for animal welfare

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Predisposing causes

A
  • Conformation
  • Excessive moisture
  • Obstructive ear dz
  • Primary otitis media
  • Treatment effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Predisposing causes - conformation

A
  • Excessive hair growth in canals (e.g. poodle) (dogs with anagenic hair growth can have excessive hair growth)
  • Hairy concave pinna (e.g. cocker spaniel)
  • Pendulous pinna (e.g. basset hound)
  • Stenotic canals (e.g. shar pei)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Predisposing causes - excessive moisture

A
  • Environment (heat & high humidity)
  • Water (swimmer’s ear, grooming, cleaners)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Predisposing causes - obstructive ear dz

A
  • Feline apocrine cystadenomatosis
  • Neoplasia & polyps
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Predisposing causes - primary otitis media

A
  • Primary secretory otitis in CKCS, tumour or sepsis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Predisposing causes - tx effects

A
  • Altered normal microflora (e.g. inappropriate cleaner)
  • Trauma from cleaning or plucking
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Primary causes

A

Parasites
- Otodectes cynotis
- Demodex spp.
- Scabies

Foreign bodies
- Grass awns

Hypersensitivity
- Atopic dermatitis, food hypersensitivity, medications

Keratinisation disorders
- Primary idiopathic seborrhoea
- Hypothyroidism

Glandular disorders
- Cocker spaniels, English springer spaniels & Labrador retrievers have increased ceruminous glands

Miscellaneous
- e.g. feline proliferative & necrotising otitis externa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Otodectes cyanotis

A
  • Common cause of otitis
    hypersensitivity disease
    – Carrier / non-clinically affected state
    – Hypersensitivity disease
    – Ectopic disease
  • Most ear creams are effective with localised disease
    –Selamectin or moxidectin spot-on
    –Likely that the isoxazoline group are effective
  • May need a cleaner ± steroids
  • Lays long eggs
  • Usually brown wax
  • Run away from light when put otoscope on them
  • Can be very sore
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Foreign body otitis

A
  • Grass seeds most common
    – Late spring to end of summer
    – Often stimulate violent response in the affected individual – sudden onset
    – Check the other ear
    – Can be hidden in discharge and migrate into middle ear
  • Painful - chemical restraint is essential in most.
  • Beware the hair that looks like a grass seed and vice versa
  • Explosive onset (driving it mad)
  • Few days of anti-inflammatory steroids useful
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Hypersensitivity otitis

A
  • OE is a VERY common complication of atopic dermatitis and food allergy
  • Primary otitis is often not recognised and so inadequately treated and dogs and cats present when there is secondary infection
  • Prevention of recurrence
    – Treat 1˚disease
    – Ensure perpetuating factors are treated
    – Ensure owner knows to intervene early
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Secondary disease - Bacteria

A

acute disease (generally):
- Gram-positive bacteria
– Staphylococcus species
– Streptococcus species
– Corynebacterium species
– aka commensals of the normal ear

chronic disease (generally):
- Gram-positive bacteria
– Enterococcus species
- Gram-negative bacteria
– Pseudomonas species
– Proteus species
– Escherichia coli
– perpetuating changes, thickening, lack of epithelial migration -> tend to get things from the environment
– trickier to deal with

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Secondary disease - Fungi

A
  • Acute & chronic disease
    – Malassezia spp.(common)
    ->Malassezia pachydermatis
    ->Lipid dependent Malassezia spp.
    – Candida spp. (uncommon)
    – Aspergillus spp. (v. v. uncommon)

Some Candida spp in people and occasionally in dogs are very dangerous re drug resistance in people

18
Q

Perpetuating factors

A
  • Pathological changes in the external ear canal (change sin canal wall, changes in glandular tissue, changes in the tympanum)
  • Otitis media
19
Q

Hidradenitis

A

= inflammation around ceruminous glands (more generally around sweat glands)

20
Q

Perpetuating factors - changes in canal wall

A
  • Inflammation causing failure of epithelial migration
  • Acute change: oedema, hyperplasia
  • Chronic change: proliferative change, canal stenosis, calcification of pericartilaginous fibrous tissue
21
Q

Perpetuating factors - changes in glandular tissue

A
  • Hyperplasia of ceruminous and sebaceous glands, hidradenitis
  • large increase in ceruminous gland -> useless/unhelpful wet watery wax
22
Q

Perpetuating factors - changes in the tympanum

A
  • Dilation, rupture, diverticulum (false middle ear – cholesteatoma)
23
Q

Perpetuating factors - otitis media

A

Acute
- foreign material
- mucopurulent exudate

Chronic
- biofilm formation
- granulation material
- bony change in the bulla

24
Q

Clinical signs of OE - Presenting reasons

A
  • Aural / otic pruritus or headshaking
  • Mild to marked exudate
  • Malodour
  • Head tilt
    – Neurological or pain
  • Deafness
    – Often conduction
    – May be toxic / neurological
25
Q

Clinical signs of OE - physical findings

A
  • Erythema, swelling, scaling, discharge (otorrhea), malodour and pain
  • Secondary
    – pinnal lesions are common
    – pyotraumatic dermatitis
    – haematoma (due to damaged blood vessels)
26
Q

Disease progression

A
  • Secondary disease follows the primary cause
  • Many / most cases are not presented until secondary disease is present
    – Malassezia
    -> Staphylococci
    -> Gram negative rods
    – If treated inadequately potential for anti-microbial resistance
  • In many cases Pseudomonas aeruginosa is end point
  • Progressive pathological changes occur with time
27
Q

Microbial progression

A
  • Dysbiosis (cytology unremarkable) –> Erythroceruminous OE (cytology shows increase in commensal microbes) –> Purulent OE (cytology shows neutrophilic inflammation & microbes)
  • once becomes OE: Mallassezia +/- Staph -> Staph -> Gram negative rods (often Pseudomonas)
  • Multiple tx along the path means huge potential for antimicrobial resistance
28
Q

Progressive pathological changes that occur as the disease progresses over time

A
  • Epidermal hyperkeratosis and hyperplasia
  • Dermal oedema
  • Fibrosis
  • Ceruminal gland hyperplasia and dilation
  • Abnormal epithelial cell migration
  • Tympanic membrane alterations
  • Otitis media (16% of acute OE, 50–80 % of chronic OE)
29
Q

Swimmers ear

A
  • usually Pseudomonas
30
Q

To pluck the ear hair or not?

A
  • Remove loose hair that’s in telogen at the top -> will come out easily and quickly
  • Don’t remove those in anagen -> will hurt and cause damage which can/will lead to otitis externa
31
Q

History and examination

A

General health / other skin disease
- e.g. inappetence /difficulty eating, signs of atopic dermatitis

Specific ear history points
- Unilateral / bilateral
- Pruritus / head shaking / scratching
- Smell
- Head tilt
- Signs of facial paralysis

General clinical examination / other skin disease

Neurological problems

Ear carriage

Pinna and outer meatus and upper vertical canal

Smell

Always check both ears

32
Q

Otoscopy

A
  • Assistance for restraint
  • Pain
    – Do not look?
    – Admit for chemical restraint?
    – Treat for short period and then reassess?
  • Fear
    – As for pain, or pretreatment with anxiolytic (e.g. trazadone)
    – Need a long-time solution!
  • Look at the good ear first
  • Head forward and slightly downwards
  • Straighten canal and use a small cone
  • Cones must be sterilised between use
  • Some dogs loathe their noses being held tight
  • Either use a muzzle so there is no pressure, or consider holding side of head (care)
  • If the head moves a lot during otoscopy, the procedure is likely to be painful
  • Chill protocol (Gabapentin and Trazadone can be useful)
33
Q

Examination points

A

Canal
- Wall - swelling ulceration, hyperplasia, hair, masses, redness
- Lumen - wax, pus, ear mites, foreign bodies and occlusion

Drum
- Present or absent, changes in colour, bulging?

Discharge / cerumen
- What is normal? wax in rings seemingly coming up the ear canal is normal
– No wax is unusual
– Heaped up or spread along the canal
- Colour
- Texture

Smell
- Useful as a measure of infection in many cases

34
Q

Cytology & wax exam

A
  • Usually possible, even when otoscopy is not
  • Best practice – perform in ALL cases
  • Affected by treatments which are often oily
  • Consider taking bacteriology swab with cytology and then submit, store or dispose
35
Q

Sampling

A

Parasites (Otodectes & Demodex)
- Mix gently in LP and coverslip

Wax samples
- Poor stickiness
- Use staining rack
- Apply methylene blue only and coverslip

Purulent samples
- Stain as for cytology

36
Q

Biofilm

A
  • A common finding in otitis due to bacteria (and yeasts)
  • Biofilms = extracellular matrix material produced by bacteria, usually when the bacteria are in larger numbers and in close proximity.
  • Quorum sensing between bacteria leads to
    – Biofilm production
    – Increased toxin production
  • Leading to lack of penetration of antibiotic and disinfectant agents
  • Increased difficulty in cleaning
  • ‘snotty/mucoid/tenacious appearance’
  • marked neutrophilic exudate due to increased toxin production
37
Q

Biofilm - cytology

A
  • Lacey/filigree matrix material and zones of none or different staining material around organisms
38
Q

Bacteriology

A
  • Confirms and/or identifies bacteria present in the ear canal
    -Presence of bacteria ≠ disease – the ear is not sterile
  • Commonly affected by
    – Previous antibiotic ear creams
    – Previous otic cleaners
  • Provides susceptibility data
    – MIC and disk diffusion techniques
    – Flawed when considering topical treatment
    – e.g. MIC resistance > 64µg marbofloxacin needed, in cream delivering 3000µg/ml = 45 X more
    – This still may be ineffective for some bacteria with very effective efflux pumps systems or that produce large amounts of biofilm
39
Q

Indications - bacterial culture in otitis - cytological reasons

A
  • Rods are seen. The most suitable antibiotic treatments can only be chosen if the organisms are known
  • Marked purulent or pyogranulomatous discharge without organisms being noted. Possibility of finding a pathogen that is relevant, but also may grow organisms that are irrelevant clinically.
40
Q

Indications - bacterial culture in otitis - clinical reasons

A
  • In the event of treatment failure.
  • If there is a suspicion of meticillin-resistant Staphylococcus species (MRS).
  • If considering video otoscopy or ear flush for diagnosis or treatment in a bacterial otitis as in the event of an adverse event following these procedures, systemic antimicrobials may be required.