Otic Delivery Flashcards
Comonly Prescribed Otics
Antibiotics? 3 points
Analgesics 1
Something that losens earwax?
Steroids?
Antifungals?
Ear anatomy the middle and inner ear
and zoomed in on the Cochlea
Cochlear crosssection
More cochlear anatomy
What is inside the cochlea?
Why is this important for drug delivery?
Hearing
Picture of cochlear frequency
People can damage their hearing at different sites and this is specific to these regions
Epidemiology of hearing loss
- How common is congenital hearing loss?
- Some studies suggest?
- What percentage is syndromal?
- Nonsyndromal what percentage is from recessive gene and what percentage dominant?
Other otic diseases?
5 different ones
Which one can be given steroids and antioxidance prophylaxtically
Sudden Sensoroneural Hearing loss
Picture of organ of corti?
With lots of vocab
What are the two types of hair cells?
What is inside the hair cell?
What are the 3 modulators?
3 causes of Organ of Corti Damage?
4 types of therapy?
The hair cell only have one nucleus so it makes sense that they can die quickly
The RWM as a gateway to the inner ear
- How long has the RWM been observed?
- Why is this an attractive drug target?
RWM Structure
- Outer
- What type of cells?
- Rich in what two things?
- Continuous with?
- Junctions?
- Middle
- When is elastic density highest?
- What 3 things are in this?
- Inner
- What type of layer epithelial shape with what type of extensions?
Factors affecting RWM permeability
3 things
Membrane
Inflammation
What is passing through?
Substances that cross the RWM
Some are weird whY?
Ferritin, Albumin, latex spheres very big its weird they can get in
Factors affecting RWM transit
What impairs latex spheres to cross?
What type of ferritin can cross and what type cant?
What 4 substances can increase permeability?
Bad picture of middle ear
Clinical trade off between Control of Drug level and Risk
picture chart thing
7 different modifications
Systemic approaches to drug delivery
Flow chart
Intratympanic long acting gels how do they work?
Needle of solution in through the tympanic membrane and edge of round window once temp increases within the boudy the solution turns into a gel and sticks to the Round Window and can be absorbed due to time at active site
This is a less invasive fix
Microwick
What does it do?
And how does it work?
Is it invasive?
Middle Ear catheter
Hows it work?
Is it invasive?
Catheters- Cochlear Implant
What have they developed in recent years?
To prevent rejection of the wires the coat them with glucocorticoids that slowly release to reduce inflammation and build up of scar tissue
Modeling inner ear drug delivery
LADME?
RWM is like?
How does delivery work?
Essentially a very small hole in a narrowing hallway
Modeling Inner ear Drug delivery Concentration gradients and graphs
Bottom is distance
Stating with cochlea
