Others Flashcards
condition where the microbial biomass (e.g., bacteria, yeast, or other microorganisms) within the bioreactor is removed at a rate equal to or faster than it is being produced or grown
washout
Mass balance on cells in a well-mixed batch fermenter
𝑑𝑀/𝑑𝑡 = 𝑀𝑖 − 𝑀𝑜 + 𝑅𝐺 − 𝑅c
occur when the flow rate is increased so that the microbes can no longer reproduce fast enough to maintain a population, the microbes wash out of the tank, and the reaction ceases
washout
_______ point represents the limits of the maximum flow rate for operation
washout
it prevents the desired microbial activities from taking place
washout
Washout can lead to
decreased reactor efficiency, reduced product formation, and difficulty in maintaining a
specific microbial population
Prevent washout
Adjusting the flow rates, dilution rates, and reactor volume
As we increase the dilution rate, eventually we are going to get to a point where the cell
concentration is
zero
If cell concentration is zero, it is called
washout
The rate of biomass production in a CSTR is __________ to the rate at which cells leave the
reactor, Fx
equal
The rate of biomass production reaches a maximum at the ___________ for
biomass productivity
optimum dilution rate
Operation of a ______ at Dopt gives the maximum rate of biomass production from the reactor
chemostat
a bioreactor to which fresh medium is continuously added, while culture liquid
containing left over nutrients, metabolic end products and microorganisms is continuously
removed at the same rate to keep the culture volume constant
Chemostat
In this process, the product stream from the first reactor feeds directly into the
second reactor
Chemostat with cascade
This is advantageous if the reactor conditions required for growth are different from
those required for product synthesis.
Chemostat with cascade
