other types of diabetes

Question 1

other types of diabetes

Answer 1

MODY

gestational dm

Question 2

what is MODY

Answer 2

monogenic diabetes melitus

or maturity onset diabetes of young

Question 3

what causes MODY and inheritance

Answer 3

autosomal dominant single gene defect

Question 4

% of MODY in dm

Answer 4

<5%

Question 5

what age does MODY present

Answer 5

non insulin requiring dm before age of 25 years

Question 6

what is MODY1 AND TREATMENT

Answer 6

HNF4a responds well to SU

Question 7

what is MODY2 and teratment

Answer 7

GCK glucokinase gene on beta cell glucose sensing

often dont need treatment as is just an altered set point for insulin release

Question 8

what is MODY3 and treatment

Answer 8

most common in uk
beta cell transcription reg HNF1A
responds to su in childhood but later need insulin treatment

Question 9

what is MODY5 ASSOCIATIONS AND TREATMENT

Answer 9

HNF1b

Assoc. to renal cysts and responds to su treatment but later need insulin

Question 10

cause of neonatal diabetes

Answer 10

mutation in KATP channel in pancreatic B cells causing insulin deficiency and DKA

Question 11

definition of gestational diabetes

Answer 11

diabetes with first onset or recognition in pregnancy

Question 12

women at high risk of gestational diabetes

Answer 12

BMI>30
previous macrosomic baby >4.5
phx gestational dm
1st degree releative with DM
high risk ethnicity

Question 13

dx criteria for gestational dm

Answer 13

fasting plasma glucose >5.1

ogtt >8

Question 14

what cant be used in pregnancy

Answer 14

SU some

Question 15

treatment of gestational dm

Answer 15

metformin or glibenclamide

or insulin if get neonatal hyperinsulinaemia