Other Major Blood Groups Flashcards by wilson maningo

Landsteiner-Wiener

ISBT 016

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LW gene is on

Chromosome 19

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LW antigen is carried by

ICAM-4

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To differentiate D antigens from LW, treat cells with

Dithiothreitol (DTT)

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Lewis

ISBT 007

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Not intrinsic to RBCs; produced by tissue cells and secreted into body fluids

Lewis

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Le gene is found on

Chromosome 19

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Le (a+b+)

Asians

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lele

Blacks

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Present only if both Le and Se are present

Leb

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Associated with H.pylori infection

Leb

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MNSs

ISBT 002

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MNSs gene is located on

Chromosome 4

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Well developed at birth; may cause HDN; demonstrate dosage effect; used in paternity testing

MNSs

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Abs react more strongly with homozygous RBCs

Dosage effect

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Found on glycophorin A; differ at amino acids at pos 1&5

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Found on glycophorin B; differ at amino acids at pos 29

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Formed when individual is S+s+

U phenotype

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Cold reacting; IgG/IgM; rxn enhanced at 6.5 (acidic); seen in multiparous women

Anti-M

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Cold reacting; IgG/IgM; rxn enhanced at alkaline pH; seen in renal dialysis patients

Anti-N

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MNSs Ab that is IgG in nature; may cause HDN&HTRs

Anti-S & Anti-s

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Found in S-s- individuals; may cause HDN&HTRs

Anti-U

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Receptor for E.coli

Glycophorin A

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Receptor for P.falciparum

Glycophorin A&B

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P1Pk

ISBT 003

Deteriorates rapidly upon storage; may cause false neg in old specimens; poor expression at birth

P1 antigen

Full expression of P1 Ag

7 years old

Slightly more common in Japan, North Sweden, and in an Amish group in Ohio

P null

Receptor for Parvovirus B19 Ag

P antigen

Receptor for Shiga toxin

Pk antigen

Receptor for P fimbriated uropathogenic E.coli

All P antigens

Naturally occurring; IgM; neutralized by hydatid cyst fluid from E. Granulosus; found in patients with fasciolasis

Anti-P1

IgM/IgG; first described in patient suffering from adenocarcinoma of the stomach; associated with spontaneous abortions in early pregnancy

Anti-PP1Pk (Anti-Tja)

IgG autoAb; biphasic hemolysin; aka Donath-Landsteiner Ab; produced by patients with Paroxysmal Cold Hemoglobinuria

Autoanti-P

Associated with Cold Agglutinin Disease & Primary Atypical Pneumonia (Walking Pneumonia caused by Mycoplasma pneumoniae)

Anti-I / Pathogenic Autoanti-I

Associated with IM, EBV infxn; alcoholic cirrhosis

Anti-i

Associated with congenital cataracts

Adult I

Disease associated with individuals that do not convert i to I after 18 months

Hereditary Erythroblastic Multinuclearity with Positive Acidified Serum (HEMPAS) test or Chronic Dyserythropoietic Anemia II

I blood group

ISBT 027

Kell

ISBT 006

KEL gene is found on

Chromosome 7

IgG; reactive in AHG phase; warm reacting; severe HDN and HTR

Anti-K

Produce by Ko phenptype; cause HTR&HDN

Anti-Ku

Result of infection from Steptococcus/Enterococcus faecium

Acquired K phenomenon

Associated with E.coli 0125 B15 infxn

Anti-K

Absence of Kx on WBCs

Chronic Granulomatous Disease

Chracterized by neuroacanthocytosis, cardiomegaly, muscular dystrophy, cardiomyopathy, areflexia, inc. Creatine Phosphokinase and Carbonic Anhydrase III

McLeod Syndrome

Absence of Kx and Km on RBCs; depressed expression of all Kell antigens; X-linked; acanthocytosis

McLeod Phenotype

Duffy

ISBT 008

Fy gene is found on

Chromosome 1

Made by duffy null individuals

Anti-Fy3

Resistance to P. Vivax and P.knowlesi infections; seen in Blacks

Duffy null

Kidd

ISBT 009

Jk gene is found on

Chromosome 18

Notorious in blood banks that cause delayed severe and fatal HTR; rarely cause HDN

Anti-Jka & Anti-Jkb

Drug-induced HTR in patients taking Aldomet or Methyldopa (hypertensive drugs)

Anti-Jka & Anti-Jkb

Found in Jk (a-b-); severe and immediate and delayed HTRs; mild HDN

Anti-Jk3

IgM Abs

"LIPMAN" 1) Lewis 2) l 3) P1 4) M 5) ABH 6) N

IgG Abs

1) Rh 2) SsU 3) Duffy (Fy) 4) Kell (K) 5) Kidd (Jk) 6) Lutheran (Lb)

MF rxn

1) Lutheran 2) Sda

Absent in PNH III

1) JMH 2) Cromer 3) Cartwright 4) Dombrock

Carbohydrate Ag

"LIP" 1) Lewis 2) l 3) P

Poorly developed at birth

Lewis, Lutheran, P1

Well developed at birth

Duffy, MNSs, Kell, Kidd

In-Vitro Hemolysis

Anti Lea/Leb, Anti-Tja, Vel

Dosage effect

Rh, Duffy, MNSs, Kidd, Kell, Lutheran

HTLA Abs

Chido/Rogers, Kn, JMH, York, Cost, McCoy

Decreased Abs in pregnancy (postpartum)

Lewis, Sda (dec Ag in pregnancy)

Destroyed by enzymes

Duffy, MNS, Xga, JMH, Ch/Rg, Pr

Enhanced by enzymes

"KALIPER" 1) Kidd 2) ABO 3) Lewis 4) I 5) P1 6) Rh

Unaffected by enzymes

U, Kell, Lutheran, Scianna

Destroyed by sulfhydryl agents

Kell

Anti-P1 is neutralized by

Hydatid cyst fluid, turtle dove egg white, pigeon dropping

Anti-Le, Anti-H is neutralized by

Saliva, Plasma/serum

Anti-Ch/Rg is neutralized by

Plasma/serum

Anti-Sda is neutralized by

Guinea pig urine

I antigen is neutralized by

Mother's milk