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Block 7 Week 4 Colt > Other Disorders of Hemostasis > Flashcards

Other Disorders of Hemostasis Flashcards

1
Q

What PLT surface marker can HEP bind to?

A

PF4

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2
Q

What causes PLT destruction in heparin induced thrombocytopenia?

A

IgG binding to HEP-PF4

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3
Q

What activates the PLTs in HIT?

A

the fragments of the destroyed PLTs, leading to thrombosis

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4
Q

DIC can lead to (blank) of downstream tissue

A

infarction and ischemia

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5
Q

Where do you see bleeding in DIC?

A

IV sites and mucosal surfaces

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6
Q

How does pregnancy cause DIC?

A

TT from the amniotic fluid may initiate coag cascade

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7
Q

Sepsis from what two bugs can cause DIC?

A

E. coli and N. meningitidis

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8
Q

Macrophages release what two cytokines during sepsis that can lead to DIC?

A

TNF-a and IL-1

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9
Q

What is is about infx with E. coli and N. meningitidis that leads to DIC?

A

release of endotoxins

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10
Q

(blank) from adenocarcinoma can lead to DIC

A

mucin

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11
Q

Primary granules that go on to form Auer rods in (blank) can cause DIC

A

Acute promyelocytic leukemia

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12
Q

what kind of snake bite can cause DIC?

A

rattlesnake

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13
Q 
What are the lab values for DIC?
PLT
PT/PTT
fibrinogen
what type of anemia
A

LOW PLT (lots of little clots)
INCREASED PT AND PTT (consumption of cascade)
decreased fibrinogen (making clots)
MAHA

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14
Q

What is the best test to screen for DIC?

A

D-dimer

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15
Q

Are d-dimers formed from the splitting of fibrin or fibrinogen?

A

fibrin; FROM LYSIS OF ALREADY PRESENT CLOT

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16
Q

Besides addressing the underlying condition causing the DIC, what supportive care can you give the patient?

A

transfusion of cryoprecipitate

17
Q

What converts plasminogen to plasmin?

A

tPA

18
Q

Plasmin cleaves (blank) and serum (blank), destroys coagulatoin factors, and blocks platelet (aggregation/adhesion)

A

cleaves fibrin and serum fibrinogen

blocks PLT aggregation

19
Q

What inactivates plasmin?

A

a2-antiplasmin

20
Q

A radical prostatectomy resulting in large releases of urokinase or cirrhosis of the liver resulting in decreased a2-antiplasmin can both result in increased (blank)

A

bleeding

21
Q

What other disorder do issues of fibrinolysis resemble clincally?

A

DIC

22
Q 
Describe the labs for fibrinolytic disorders:
PT/PTT
bleeding time
PLT
D-dimers (present/absent)
A

increased PT/PTT
increased bleeding time
NORMAL PLTS; THERE ARE NO CLOTS, JUST ACTIVATION OF CLOT BUSTER
NO D-DIMER BECAUSE NO ACTUAL CLOTS

23
Q

What is the Tx for issues of tPA overdose or fibrinolytic disorders?

A

aminocaproic acid, blocks activation of plasminogen

Block 7 Week 4 Colt (9 decks)

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