Other chemotherapies & review Flashcards
Which of the following is a topoisomerase inhibitor?
Carboplatin
Irinotecan
Paclitaxel
Methotrexate
Irinotecan
Chemotherapy can be selective for cancers cells over normal cells for what reasons?
Some cancers grow faster than normal cells
Some cancers have defective cell cycle checkpoints
Some cancer selectively activate prodrugs of chemotherapy agents
All of the above
All of the above
Which drug targets the kinases directly involved in cell cycle control?
Question options:
Dabrafenib
Olaparib
Lapatinib
Palbociclib
Palbociclib
What is the most common DOSE-LIMITING side effect for cancer therapeutics?
Neuropathy
Rash
Nephrotoxicity
Myelosuppression
Myelosuppression
One of the most common forms of leukemia is Chronic Myelogenous Leukemia (CML). In most cases these leukemic cells contain a chromosomal abnormality that is a “target” for drug therapy that is not seen in non-leukemic white blood cells. A current treatment of choice for this form of cancer is:
Trastuzumab
Bortemzomib
Imatinib
Tamoxifen
Imatinib
SM is a 52-year-old man with a new diagnosis of metastatic lung adenocarcinoma. Complete pathologic review revealed a translocation of EML4-ALK. Which therapy would be prescribed?
Quizartinib
Gefitinib
Alectinib
Imatinib
Alectinib
A postmenopausal woman is diagnosed with ER-/HER2+ breast cancer and is treated with standard of care first-line therapy. First line therapy here could consist of which two antibodies?
A bispecific antibody and an antibody that binds the TCR
Pertuzumab and Bevacizumab
Trastuzumab and Rituximab
Pertuzumab and Trastuzumab
Pertuzumab and Trastuzumab
Which of the following is not a cell type found in solid tumors?
Blood vessels
T-cells
Tumor cells
All are found in solid tumors
All are found in solid tumors
Which of following agents is appropriate regarding the treatment of women with ER-positive breast cancer?
Letrozole may be used in pre and postmenopausal women
Tamoxifen may be used in pre and postmenopausal women
Abiraterone may be used in pre and postmenopausal women
Enzalutamide may be used in pre and postmenopausal women
Tamoxifen may be used in pre and postmenopausal women
The use of which drug is based on the concept of synthetic lethality?
Methrotexate
Cisplatin
Irinotecan
Olaparib
Olaparib
Which of the following drugs acts by binding to HER2?
Trastuzumab
Pertuzumab
Margetuximab
All of the above
All of the above
Which of the following drugs exerts antitumor effects by inhibiting the interaction between PD1 and PDL1?
Cetuximab
Ipilimumab
Atezolizumab
All of the above
Atezolizumab
What concept of immunity must be overcome for the immune system to successfully eliminate cancer cells?
Antibody-dependent cellular cytotoxicity
Central tolerance
T-cell activity
B-cell activity
Central tolerance
What is the function of the cetuximab?
To block EGFR ligand binding
The same as panitumumab
To binding VEGF
The same at Pertuzumab
A and B
A and B
pt is post menopausal w metastatic breast cancer to the lung (ER/PR +, HER2 -). best regimen?
> letrozole & palbociclib
laptinib & capecitabine
trastuzumab
paxlitaxel
irinotecan
> letrozole & palbociclib