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therapeutics 864 - exam 1 > chemo drugs & their classes > Flashcards

chemo drugs & their classes Flashcards

1
Q

5-FU

A

antimetabolite

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2
Q

cytarabine (Ara-C)

A

antimetabolite

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3
Q

6-MP

A

antimetabolite

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4
Q

methotrexate

A

antifolate (DHFR inhibitor)

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5
Q

chlorambucil

A

alkylator

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6
Q

cyclophosphamide

A

alkylator

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7
Q

mitomycin C

A

alkylator - antineoplastic antibiotic

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8
Q

cisplatin

A

platinum compound, alkylator, intrastrand crosslinker

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9
Q

irinotecan

A

topo I (tecans) inhibitor

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10
Q

doxorubicin

A

topo 2 inhibitor, anthracyclin, intercalator

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11
Q

etoposide

A

topo 2 inhibitor

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12
Q

bleomycin

A

glycopeptide antibiotic; intercalator

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13
Q

vincristine

A

microtubule destabilizer, vinca alkaloid

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14
Q

pacliTAXel

A

microtubule stabilizer; taxane

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15
Q

erubulin

A

microtubule destabilizer/inhibitor

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16
Q

ixabEPILone

A

epothilones (macrolide), microtubule stabilizer

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17
Q

enzalutamide

A

AR inhibitor, endocrine

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18
Q

abiraterone

A

Aromatase inhibitor - steroidal

androgen biosynthesis inhibitor (cyp17 inhibitor)

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19
Q

tamoxifen

A

SERM, prodrug, antagonist & agonist

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20
Q

fulvestrant

A

SERD, ER antagonist

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21
Q

prednisolone

A

glucocorticoid

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22
Q

letrozole

A

non steroidal aromatase (CYP19) competitive inhibitor, INDIRECT ER inhibitor

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23
Q

exemestane

A

steroidal aromatase (CYP19) irreversible inhibitor

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24
Q

leuprolide

A

GnRH agonist (premenopause & prostate cancer)

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25
Q

imatinib

A

type II (abl) kinase inhibitor

26
Q

ponatinib

A

BCR-Abl kinase inhibitor

27
Q

midostaurin

A

FLT3 kinase inhibitor

28
Q

quizartinib

A

type II FLT3 inhibitor

29
Q

crenolanib

A

FLT3 inhibitor

30
Q

sirolimus (rapamycin)

A

mTOR (serine-threonine kinase) inhibitor

31
Q

alectinib

A

ALK kinase inhibitor

32
Q

dabRAFenib

A

BRAF-v600 kinase inhibitor

33
Q

trametinib

A

type III allosteric (MEK1+2) kinase inhibitor

34
Q

acalaBRUTinib

A

2nd gen covalent BTK inhibitor (ErbB family of tk)

35
Q

Gefitinib

A

type I EGFR kinase inhibitor

36
Q

lapatinib

A

HER2 & EGFR kinase inhibitor

use with capecitabine

37
Q

afatinib

A

covalent EGFR kinase inhibitor (ErbB family of tk)

38
Q

tucatinib

A

HER2 kinase inhibitor

39
Q

Osimertinib

A

3rd gen covalent EGFR kinase inhibitor (type IV) (ErbB family of tk)

40
Q

pembrolizumab

A

PD-1 receptor blocker

41
Q

atezolizumab

A

PD-L1 blocker

42
Q

ipilimumab

A

CTLA-4 receptor inhibitor –> reverse CTL inhibition

43
Q

trastuzumab & pertuzimab

A

HER2 inhibitor

44
Q

cetuximab

A

EGF & TGF-alpha inhibitor

blocks EGFR –> skin rxns

45
Q

bevacizumab

A

VEGF –> binds the LIGAND

46
Q

ramucirumab

A

VEGF 2 –> binds the RECEPTOR

47
Q

rituximab

A

binds CD20

48
Q

daratumumab

A

binds CD38

49
Q

trastuzumab emtansine

A

antibody drug conjugate (ADC)

HER/Neu receptor & microtubule assembly inhibition

50
Q

trastuzumab deruxTECAN

A

antibody drug conjugate (ADC)

HER2/Neu receptor & topo 1 inhibitor

51
Q

blinatumomab

A

bispecific antibody t cell engager (BiTE)

CD3 & CD19

52
Q

mosunetuzumab

A

bispecific antibody t cell engager (BiTE)

CD3 & CD20

53
Q

teclistamab

A

bispecific antibody t cell engager (BiTE)

CD3 & BCMA

54
Q

taquetamab

A

bispecific antibody t cell engager (BiTE)

CD3 & GPRC5D

55
Q

CAR-T

A

cell based therapy, t cells (CD19)

56
Q

sipuleucel-T (provenge)

A

cell based therapy, therapuetic vaccine, APC ex vivo activation

57
Q

olaPARib

A

PARP inhibitor

58
Q

PalboCIClib

A

CKD4/6 kinase inhibitor (cyclin-dependent kinase)

59
Q

bortemzomib

A

proteasome inhibitor (26S)

60
Q

5-azacytosine

A

DNMT inhibitor

tumor suppressor gene reactivator

61
Q

veneteclax

A

BCL-2 inhibitor (BCL-2 allows apoptosis evasion in cancer cells)

62
Q

pomalidomide

A

immunomodulator, PROTACs

binds cereblon, degrads IKZF-TFs

therapeutics 864 - exam 1 (10 decks)

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