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therapeutics 864 - exam 1 > chemo drugs & their classes > Flashcards

chemo drugs & their classes Flashcards

1
Q

5-FU

A

antimetabolite

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2
Q

cytarabine (Ara-C)

A

antimetabolite

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3
Q

6-MP

A

antimetabolite

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4
Q

methotrexate

A

antifolate (DHFR inhibitor)

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5
Q

chlorambucil

A

alkylator

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6
Q

cyclophosphamide

A

alkylator

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7
Q

mitomycin C

A

alkylator - antineoplastic antibiotic

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8
Q

cisplatin

A

platinum compound, alkylator, intrastrand crosslinker

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9
Q

irinotecan

A

topo I (tecans) inhibitor

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10
Q

doxorubicin

A

topo 2 inhibitor, anthracyclin, intercalator

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11
Q

etoposide

A

topo 2 inhibitor

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12
Q

bleomycin

A

glycopeptide antibiotic; intercalator

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13
Q

vincristine

A

microtubule destabilizer, vinca alkaloid

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14
Q

pacliTAXel

A

microtubule stabilizer; taxane

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15
Q

erubulin

A

microtubule destabilizer/inhibitor

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16
Q

ixabEPILone

A

epothilones (macrolide), microtubule stabilizer

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17
Q

enzalutamide

A

AR inhibitor, endocrine

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18
Q

abiraterone

A

Aromatase inhibitor - steroidal

androgen biosynthesis inhibitor (cyp17 inhibitor)

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19
Q

tamoxifen

A

SERM, prodrug, antagonist & agonist

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20
Q

fulvestrant

A

SERD, ER antagonist

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21
Q

prednisolone

A

glucocorticoid

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22
Q

letrozole

A

non steroidal aromatase (CYP19) competitive inhibitor, INDIRECT ER inhibitor

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23
Q

exemestane

A

steroidal aromatase (CYP19) irreversible inhibitor

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24
Q

leuprolide

A

GnRH agonist (premenopause & prostate cancer)

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25
imatinib
type II (abl) kinase inhibitor
26
ponatinib
BCR-Abl kinase inhibitor
27
midostaurin
FLT3 kinase inhibitor
28
quizartinib
type II FLT3 inhibitor
29
crenolanib
FLT3 inhibitor
30
sirolimus (rapamycin)
mTOR (serine-threonine kinase) inhibitor
31
alectinib
ALK kinase inhibitor
32
dabRAFenib
BRAF-v600 kinase inhibitor
33
trametinib
type III allosteric (MEK1+2) kinase inhibitor
34
acalaBRUTinib
2nd gen covalent BTK inhibitor (ErbB family of tk)
35
Gefitinib
type I EGFR kinase inhibitor
36
lapatinib
HER2 & EGFR kinase inhibitor use with capecitabine
37
afatinib
covalent EGFR kinase inhibitor (ErbB family of tk)
38
tucatinib
HER2 kinase inhibitor
39
Osimertinib
3rd gen covalent EGFR kinase inhibitor (type IV) (ErbB family of tk)
40
pembrolizumab
PD-1 receptor blocker
41
atezolizumab
PD-L1 blocker
42
ipilimumab
CTLA-4 receptor inhibitor --> reverse CTL inhibition
43
trastuzumab & pertuzimab
HER2 inhibitor
44
cetuximab
EGF & TGF-alpha inhibitor blocks EGFR --> skin rxns
45
bevacizumab
VEGF --> binds the LIGAND
46
ramucirumab
VEGF 2 --> binds the RECEPTOR
47
rituximab
binds CD20
48
daratumumab
binds CD38
49
trastuzumab emtansine
antibody drug conjugate (ADC) HER/Neu receptor & microtubule assembly inhibition
50
trastuzumab deruxTECAN
antibody drug conjugate (ADC) HER2/Neu receptor & topo 1 inhibitor
51
blinatumomab
bispecific antibody t cell engager (BiTE) CD3 & CD19
52
mosunetuzumab
bispecific antibody t cell engager (BiTE) CD3 & CD20
53
teclistamab
bispecific antibody t cell engager (BiTE) CD3 & BCMA
54
taquetamab
bispecific antibody t cell engager (BiTE) CD3 & GPRC5D
55
CAR-T
cell based therapy, t cells (CD19)
56
sipuleucel-T (provenge)
cell based therapy, therapuetic vaccine, APC ex vivo activation
57
olaPARib
PARP inhibitor
58
PalboCIClib
CKD4/6 kinase inhibitor (cyclin-dependent kinase)
59
bortemzomib
proteasome inhibitor (26S)
60
5-azacytosine
DNMT inhibitor tumor suppressor gene reactivator
61
veneteclax
BCL-2 inhibitor (BCL-2 allows apoptosis evasion in cancer cells)
62
pomalidomide
immunomodulator, PROTACs binds cereblon, degrads IKZF-TFs

therapeutics 864 - exam 1 (10 decks)

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