Other Blood Groups

Question 1

When are less common antigens tested for?

Answer 1

They won’t be part of a main panel, but may be tested for as needed.

Question 2

How many antigens are in the Diego System?

Answer 2

22 with three sets of independent antithetical alleles

Question 3

What are the antithetical antigens of the Diego System?

Answer 3

Di(a) / Di(b)
Wr(a) / Wr(b)
Wu / DISK

Question 4

What is the prevalence of Wu antigen?

Answer 4

High prevalence

Question 5

How many low prevalence antigens are in the Diego System?

Answer 5

17

Question 6

How do Diego antibodies react?

Answer 6

typically requires AHG

Question 7

What isotype are Diego antibodies?

Answer 7

IgG

Question 8

What is the prevalence of Diego antibodies?

Answer 8

rare in African, Caucasion, and Native American, 5% in Chinese population

Question 9

How do Diego antigens react to enzymes?

Answer 9

Not destroyed by ficin or papain

Question 10

What is the clinical significance of the Diego antibodies?

Answer 10

Di(a)-rare, serious HDFN, delayed transfusion reaction
Di(b)-no HFN or TFR
Wr(a)-HDFN
Wr(b)-autoantibody/ autoimmune hemolytic anemia

Question 11

Which antibodies show dosage?

Answer 11

Kidds and Duffy the Rhesus monkey eat lots of M&Ns.

Question 12

Which antibodies are cold reactive?

Answer 12

LliPMAbmN- Le(a), -Le(b), -I, P, -M, -A, -B, -H, -N

Question 13

Which antibodies are warm reactive?

Answer 13

Anti-, -Kell, -Duffy, -Kidd, -S, and -s

Question 14

Which antibodies are enhanced by enzymes?

Answer 14

Kidd, Rh, Lewis, I, P

Question 15

Which antibodies are destroyed by enzymes?

Answer 15

Fy(a), Fy(b), M, N, S,and s

Question 16

How does anti-K react to enzymes?

Answer 16

K is unaffected because K doesn’t care

Question 17

What antigens are missing in hereditary elliptocytosis?

Answer 17

Gp(c) and Gp(d); they help maintain RBC shape.

Question 18

Cromer antibodies can be inhibited by what?

Answer 18

by serum or plasma of antigen positive people

Question 19

Cartwright antigens are associated with what disease?

Answer 19

PCH

Question 20

Gerbich antigens function to do what in the RBC?

Answer 20

interact with a protein involved in maintenance of RBC shape

Question 21

Chido/Rogers antigens are located where?

Answer 21

on Cd4 complement molecule

Question 22

Chido/Rogers are netralized by

Answer 22

pooled plasma

Question 23

Colton antigens are involved in what RBC function?

Answer 23

water transport

Question 24

Colton antigens are associated with what genetic abnormality?

Answer 24

monosomy 7

Question 25

are Landsteiner-Weiner antigens clinically significant?

Answer 25

No

Question 26

What is the prevalence of Landsteiner-Weiner antigens?

Answer 26

High prevalence

Question 27

How are Lansteiner-Weiner antigens expressed on cells in relation to their D phenotype?

Answer 27

expressed on D+>than on D-

Question 28

Is Di(a) clinically significant?

Answer 28

Yes, but rare. Severe HDFN and delayed transfusion reaction.

Question 29

Is Di(b) clinically significant?

Answer 29

No.

Question 30

Which less common blood group is essentional for expression of Rh antigens>

Answer 30

RHAG system

Question 31

Where is Gil antigen located?

Answer 31

On aquaporin 3 (AQP3) which enhances the permeabiliey of the red cell membrane by glycerol and water.

Question 32

Is Vel antigen clinically significant?

Answer 32

Yes. Activates complement, mild to sever HTR, rare HDFN,

and it is high prevalence

Question 33

What is unique about high prevalence Jr(a)?

Answer 33

It is associated with Japanese ancestry.

Question 34

Which blood group is X-linked?

Answer 34

Xg (Xg(a)); prevalence is 66% in males; 89% in females

Question 35

The Cartwright system with antigens Yt(a) and Yt(b) are absent in what group of people?

Answer 35

people with PCH

Question 36

What are some high incidence antigens?

Answer 36

K, Kp(b), Js(b), Lu(b), U, Di(b)

Question 37

What are some low incidence antigens?

Answer 37

C(w), V, Kp(a), Js(a), Di(a)