Other Blood Groups Flashcards
When are less common antigens tested for?
They won’t be part of a main panel, but may be tested for as needed.
How many antigens are in the Diego System?
22 with three sets of independent antithetical alleles
What are the antithetical antigens of the Diego System?
Di(a) / Di(b)
Wr(a) / Wr(b)
Wu / DISK
What is the prevalence of Wu antigen?
High prevalence
How many low prevalence antigens are in the Diego System?
17
How do Diego antibodies react?
typically requires AHG
What isotype are Diego antibodies?
IgG
What is the prevalence of Diego antibodies?
rare in African, Caucasion, and Native American, 5% in Chinese population
How do Diego antigens react to enzymes?
Not destroyed by ficin or papain
What is the clinical significance of the Diego antibodies?
Di(a)-rare, serious HDFN, delayed transfusion reaction
Di(b)-no HFN or TFR
Wr(a)-HDFN
Wr(b)-autoantibody/ autoimmune hemolytic anemia
Which antibodies show dosage?
Kidds and Duffy the Rhesus monkey eat lots of M&Ns.
Which antibodies are cold reactive?
LliPMAbmN- Le(a), -Le(b), -I, P, -M, -A, -B, -H, -N
Which antibodies are warm reactive?
Anti-, -Kell, -Duffy, -Kidd, -S, and -s
Which antibodies are enhanced by enzymes?
Kidd, Rh, Lewis, I, P
Which antibodies are destroyed by enzymes?
Fy(a), Fy(b), M, N, S,and s
How does anti-K react to enzymes?
K is unaffected because K doesn’t care
What antigens are missing in hereditary elliptocytosis?
Gp(c) and Gp(d); they help maintain RBC shape.
Cromer antibodies can be inhibited by what?
by serum or plasma of antigen positive people
Cartwright antigens are associated with what disease?
PCH
Gerbich antigens function to do what in the RBC?
interact with a protein involved in maintenance of RBC shape
Chido/Rogers antigens are located where?
on Cd4 complement molecule
Chido/Rogers are netralized by
pooled plasma
Colton antigens are involved in what RBC function?
water transport
Colton antigens are associated with what genetic abnormality?
monosomy 7
are Landsteiner-Weiner antigens clinically significant?
No
What is the prevalence of Landsteiner-Weiner antigens?
High prevalence
How are Lansteiner-Weiner antigens expressed on cells in relation to their D phenotype?
expressed on D+>than on D-
Is Di(a) clinically significant?
Yes, but rare. Severe HDFN and delayed transfusion reaction.
Is Di(b) clinically significant?
No.
Which less common blood group is essentional for expression of Rh antigens>
RHAG system
Where is Gil antigen located?
On aquaporin 3 (AQP3) which enhances the permeabiliey of the red cell membrane by glycerol and water.
Is Vel antigen clinically significant?
Yes. Activates complement, mild to sever HTR, rare HDFN,
and it is high prevalence
What is unique about high prevalence Jr(a)?
It is associated with Japanese ancestry.
Which blood group is X-linked?
Xg (Xg(a)); prevalence is 66% in males; 89% in females
The Cartwright system with antigens Yt(a) and Yt(b) are absent in what group of people?
people with PCH
What are some high incidence antigens?
K, Kp(b), Js(b), Lu(b), U, Di(b)
What are some low incidence antigens?
C(w), V, Kp(a), Js(a), Di(a)
