OTC Flashcards

1
Q

H2 antagonists e.g. ranitidine. What age can you sell them to OTC?

Can you sell them to pregnant and breastfeeding women?

A

Over 16 years

No

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2
Q

What is max dose of ranitidine OTC?

A

75 mg tablets

Do not take more than 2 in 24 hours

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3
Q

True or false:

Being overweight can contribute to dyspepsia

A

True

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4
Q

True or false:

Smoking can contribute to dyspepsia

A

True

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5
Q

In what group of patients is orlistat licensed for OTC?

A

> 18 years

BMI > 28

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6
Q

What is the OTC omeprazole dose and how long can they be used for and when would you refer?

A

10mg/20mg OD
4 weeks maximum
However, if symptoms have not resolved in 2 weeks, refer
Any danger symptoms e.g. unexplained weight loss, refer

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7
Q

What age can you sell OTC omeprazole to?

A

> 18 years

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8
Q

What age can you sell esomeprazole to?

A

> 18 years

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9
Q

What age can you sell OTC esomeprazole to?

A

> 18 years

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10
Q

What is the dose of OTC esomeprazole, and what is the max time it can be used for?

A

20mg OD

2 weeks maximum

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11
Q

What is colic?

A

When a baby cries with no obvious cause

Linked to disorder of GI tract, post partum depression, anxious parents

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12
Q

How can you treat colic OTC?

A

Anti-foaming agents e.g. simethicone (Dentinox, infacol)

Gripe water

Effectiveness is lacking however

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13
Q

What are symptoms of colic?

A

High pitched crying
Often at same time of day
Drawing knees up to stomach

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14
Q

When would you refer with colic?

A

Failure to put on weight
OTC treatment failure
Danger symptoms
Over anxious parents

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15
Q

What is 1st line for constipation?

A

Lifestyle measures

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16
Q

Generally, laxatives should be avoided in constipation as first line and lifestyle measures should be tried. What exemptions would you want to treat with laxatives?

A

If straining would exacerbate a condition e.g. angina

Or increase bleeding risk e.g. haemorrhoids

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17
Q

Why must bulk forming laxatives be taken with adequate fluids?

A

To avoid intestinal obstruction

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18
Q

Frequent use of stimulant laxatives can lead to what?

A

Fluid and electrolyte imbalance

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19
Q

How long does it take for glycerol suppositories to work?

A

Within 30 mins

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20
Q

What are the preferred type of laxative in children?

A

Osmotic

Bulk forming

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21
Q

What are the safest laxatives to use in pregnancy and breastfeeding?

A

Bulk forming and osmotic

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22
Q

Why are stimulant laxatives not really recommended in breastfeeding and pregnancy?

A

Not advisable in the third trimester as it may induce uterine contractions. Senna enters the breast milk, so may cause colic and diarrhoea in the infant.

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23
Q

At what point is constipation classed as chronic?

A

Lasting 6 weeks or more

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24
Q

If a patient has constipation along with tiredness, what could be underlying causes?

A

Hypothyroidism

Anaemia

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25
Q

How long does it take for bulk forming laxatives to work?

A

12- 72 hours

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26
Q

What age can you sell Senna OTC to?

A

> 12 years

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27
Q

What age can you sell Sodium picosulphate (Dulcolax pico liquid) OTC to?

A

> 10 years

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28
Q

What age can you sell ispaghula husk OTC to?

A

> 6 years

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29
Q

Is Movicol is licensed for acute, chronic or both types of constipation?

A

Chronic

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30
Q

What are danger symptoms in a diarrhoea patient that prompts a referral?

A
Confusion 
Drowsiness
Passing little urine
Dry mouth
Sunken eyes
Duration of 3 days or longer in adults 
>24 hours in babies
>48 hours in young chuldren
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31
Q

What is the difference between Diarolyte and Diarolyte Relief?

A

Relief contains rice power and normal diarolyte is glucose based

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32
Q

What age can you sell loperamide OTC to?

A

12 years and over

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33
Q

What is the maximum dose of loperamide a day?

A

16mg

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34
Q

Does rectal bleeding from haemorrhoids need to be referred?

A

No unless excessive bleeding occurs or has occurred for more than 3 weeks

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35
Q

What kind of laxative should be used for IBS?

A

Bulk forming

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36
Q

What age can you sell mebeverine OTC?

A

> 18 years

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37
Q

What age can you sell Buscopan OTC?

A

12 years and over

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38
Q

What age can you sell Colpermin IBS relief capsules OTC? (peppermint oil)

A

15 years and over

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39
Q

What are the symptoms of haemorrhoids?

A

Bleeding, perianal itching, mucus discharge and pain

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40
Q

How many days max should you use Anusol HC plus ointment OTC?

A

7 days max

contains hydrocortisone

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41
Q

Can you use anusol HC plus ointment OTC in pregnancy and breastfeeding?

A

No

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42
Q

A cough for how many weeks would prompt a referral?

A

Longer than 3 weeks

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43
Q

What is croup?

A

Croup in children is caused typically by the parainfluenza virus. It often starts with a cold and develops into a characteristic barking cough

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44
Q

What time of the day are symptoms of croup the worst?

A

At night

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45
Q

How can you treat croup?

A

No medical treatment as it is viral but can offer antipyretic treatment if fever is present

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46
Q

Systemic decongestants should be used with caution in what group of patients?

A

They should be used with caution in people with diabetes, hypertension, hyperthyroidism, raised intraocular pressure, prostatic hypertrophy, hepatic or renal impairment, or ischaemic heart disease.

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47
Q

Systemic decongestants are contraindicated in patients taking what medicine class?

A

MAOIs

Risk of hypotensive crisis

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48
Q

What is a purpuric rash?

A

One which does not blanch white on pressure

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49
Q

Bonjela preparations containing choline salicylate is unsuitable for which age group?

A

Under 16 years

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50
Q

What is the licensed age range for sumatriptan OTC?

A

18-65

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51
Q

What is the maximum dose of OTC sumatriptan?

A

Single 50mg dose stat
Can take another 50mg tablet but has to be at least 2 hours after taking the first tablet
Max 100mg in 24 hours/to treat the same attack

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52
Q

What groups of patients is sumatriptan OTC unsuitable for?

A
  • Previous myocardial infarction
  • Ischaemic heart disease, e.g. angina
  • Peripheral vascular disease
  • Cardiac arrhythmias (including Wolff-Parkinson-White syndrome)
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53
Q

What is 1st line for pregnancy in threadworm?

A

Strict hygiene measures

Refer if this has not worked

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54
Q

What is the dosing instructions for mebendazole in threadworm?

A

Once only dose

Can be repeated after 2 weeks if it has not cleared up

Everyone in the house should be treated

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55
Q

What age group is mebendazole not suitable for?

A

<2 years

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56
Q

What is recommended as first line for head lice treatment in pregnancy and BF?

A

Wet combing

If treatment needed, Dimeticone e.g. Hedrin

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57
Q

What is recommended as first line for head lice treatment in asthma and eczema?

A

Wet combing

If treatment needed, Dimeticone e.g. Hedrin

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58
Q

How many times should you apply head lice treatment and how many days should you leave between each treatment course?

A

Twice

At least 7 days between

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59
Q

What is first line for scabies?

A

Permethrin 5% w/w cream (Lyclear®)

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60
Q

What is first line for scabies in pregnancy and BF?

A

Permethrin 5% w/w cream (Lyclear®)

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61
Q

Where should you apply scabies lotion?

A

All over the body

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62
Q

What is 1st line for athlete’s foot in pregnancy and breastfeeding?

A

Topical imidazoles e.g. Daktarin Gold

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63
Q

What is the minimum age for Lamisil OTC (terbinafine) for athelete’s foot (tinea pedis)?

A

> 16 years

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64
Q

What is the maximum number of nails you can treat OTC for fungal nail infection?

A

2

If more than this, need to refer

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65
Q

Amorolfine lacquer is licensed OTC for what condition and what is the age restriction?

A

Fungal nail infection

18 years and over

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66
Q

How can ringworm (tinea corpis) and jock itch (tinea cruris) be treated OTC?

A

Most local infections can be treated adequately with topical antifungal preparations. Imidazoles (clotrimazole, econazole, miconazole) or terbinafine are suitable first-line treatments for groin infections and skin ringworm.

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67
Q

How can sweat rashes be treated OTC?

A

Topical imidazoles e.g. Daktarin

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68
Q

What should you do if someone comes into the pharmacy with impetigo?

A

Usually needs a prescription to treat it so refer

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69
Q

What age groups should be referred in vaginal thrush?

A

<16 years

>60 years

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70
Q

True or false:

Poorly controlled diabetes is linked with thrush

A

True

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71
Q

Women who have had more than how many episodes of thrush in 6 months- when should you refer to GP?

A

More than 2 episodes in last 6 months

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72
Q

Can you treat a pregnant person OTC for thrush?

A

No- refer

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73
Q

What NSAID (stronger than ibuprofen) is available OTC for primary dysmenorrhoea?

A

Feminax ultra

250mg naproxen

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74
Q

What age range is Feminax ultra licensed for?

A

15-50 years

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75
Q

What age would you refer for bacterial conjunctivitis?

A

<2 years

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76
Q

Can you treat bacterial conjunctivitis OTC for pregnancy and breastfeeding?

A

No- refer

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77
Q

An ulcer lasting than more than how many weeks should be referred?

A

More than 3 weeks- exclude oral cancer

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78
Q

What is the minimum age to use Difflam mouthwash?

A

12 years

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79
Q

What is the minimum age to use Difflam spray?

A

6 years

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80
Q

What is a common side effect on the teeth if a patient is having chlorhexidine mouthwash?

A

Stains teeth brown

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81
Q

What is the minimum age to use miconazole 2% oral gel for oral thrush?

A

> 4 months

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82
Q

Should miconazole oral gel be applied before or after meals?

A

After and held in the mouth as long as possible

83
Q

What anticoagulation interacts with miconazole oral thrush gel and prompts a referral?

A

Warfarin

84
Q

If a patient has diabetes and presents to the pharmacy with oral thrush, what should you do?

A

Refer

85
Q

What is angular stomatitis?

A

Cracked fissures in the corners of the mouth

86
Q

What can you offer OTC for angular stomatitis?

A

Clotrimazole 1% cream

87
Q

True or false:

Diuretics can cause dry eyes

A

True

88
Q

What is the minimum age to use hydrocortisone 1% cream OTC?

A

10 years

89
Q

What is the maximum number of days to use OTC steroid cream?

A

7 days

90
Q

What steroid creams are available OTC?

A

Hydrocortisone 1% and clobetasone butyrate 0.05%

91
Q

What areas can you not put OTC steroid cream?

A

Facial skin, broken skin, genitals

You can put it on ears as this does not count as your face

92
Q

Can you give steroid creams OTC to pregnant women?

A

No

93
Q

Are OTC steroid creams licensed for psoriasis flare ups?

A

No

94
Q

What age range is OTC tranexamic acid licensed for in heavy periods?

A

18-45 year olds

95
Q

At what age are you eligible for the free flu vaccine?

A

65 years and older

96
Q

Coughing up thin and frothy mucous can suggest what?

A

Left ventricular failure

97
Q

What age can you sell OTC guaifenesin cough syrup?

A

> 6 years (Benylin chesty cough for children)

98
Q

What age can you sell OTC diphenhydramine cough syrup?

A

> 6 years (Benylin children’s night cough)

99
Q

What age is otrivine child nasal drops licensed in?

A

6-12 years

Contains xylometazoline

100
Q

What age are Tyrozets (benzocaine) lozenges licensed in?

A

> 3 years

101
Q

Is Ella One recommended in a patient with severe uncontrolled asthma?

A

No, especially if being treated with an oral glucocorticoid

102
Q

Tamsulosin 400mcg capsules can be sold to what group of patients over the counter?

How long can they take this before assessment is needed by a doctor?

A

Treatment of functional symptoms of benign prostate hyperplasia in men ages 45-75 years

Can be taken for up to 6 weeks before clinical assessment by a doctor

103
Q

What is the patient advice surrounding sunlight and cold sores?

A

Sunlight can trigger cold sores so direct sunlight should be avoided and sun screen should be applied.

104
Q

Is oral lidocaine for children (Anbesol, Bonjela):

  • P medicine
  • GSL
  • POM?
A

P medicine

Changed from GSL in late 2018

Max pack size 10g

105
Q

What is the MHRA advice surrounding the sale of oral lidocaine for children?

A
  • Gone from GSL to P medicine
  • Restriction of pack size of 10g
  • Moved to second line after non-pharmacological management
106
Q

What advice would you give to breastfeeding women being treated for scabies?

A

Breastfeeding women should remove the treatment from the nipples before feeding, and reapply afterwards.

107
Q

Buccastem is licensed for what age OTC?

A

18 years

108
Q

Anusol Plus HC is licensed for what age OTC?

A

18 years

109
Q

Corticosteroid nasal sprays are licensed for what age OTC?

A

18 years

110
Q

Tranexemic acid is licensed for what age OTC?

A

18 years

111
Q

Canesten thrush cream is licensed for what age range OTC?

A

16-60 years

112
Q

Azithromycin (OTC for chlamydia) is licensed for what age?

A

16 years

113
Q

Nytol is licensed for what age OTC?

A

16 years

114
Q

Feminax ultra OTC is licensed for what age?

A

15-50 years

115
Q

Voltarol gels OTC are licensed for what age?

A

14 years

116
Q

Rennie is licensed for what age OTC?

A

12 years

117
Q

Gaviscon is licensed for what age OTC?

A

12 years

118
Q

Woodwards Gripe water OTC is licensed for what age range?

A

1 month- 1 year

119
Q

Calpol OTC is licensed from what age?

A

2 months

120
Q

Nurofen OTC is licensed from what age?

A

3 months

121
Q

Daktarin 2% oral gel is licensed from what age otc?

A

4 months

122
Q

Hedrin and Derbac liquid is licensed from what age OTC?

A

6 months

123
Q

Piriton OTC (chlorphenamine) is licensed from what age?

A

1 year

124
Q

What age is Diarolyte relief OTC licensed for?

A

1 year

Under this age needs medical advice

125
Q

OTC choramphenicol is licensed for what age?

A

2 years

126
Q

Mebendazole OTC is licensed for what age?

A

2 years

127
Q

Lyclear cream OTC is licensed for what age?

A

2 years

Under this age needs medical advice

128
Q

Loratadine OTC is licensed what from age?

A

2 years (as long as they weigh more than 30 kg)

129
Q

Phenergan OTC is licensed from what age?

A

2 years

130
Q

What is the active ingredient in Joy Rides?

A

Hyoscine hydrobromide

131
Q

Joy Rides OTC is licensed from what age?

A

3 years

132
Q

Kwells OTC is licensed from what age?

A

4 years

133
Q

Sturgeon (cinnarizine) is licensed from what age?

A

5 years

134
Q

What are the 6 stages of transtheoretical model of change?

A
  1. Pre-contemplation
  2. Contemplation
  3. Preparation
  4. Active
  5. Maintenance
  6. Relapse
135
Q

Is evaluation a stage in the transtheoretical model of change?

A

No

136
Q

What is tranexamic acid licensed for?

A

Heavy menstrual bleeding over several cycles with regular cycles

137
Q

What are the dosing instructions for tranexamic acid OTC?

A

Taken only once heavy bleeding has started
2 500mg tablets TDS until symptoms are alleviated
(Can be increased to 8 tablets a day 4g for heavier periods)

It will not work properly if taken before menstruation

It should not be taken for more than 4 consecutive days

138
Q

What is the max number of days you should use tranexamic acid OTC for?

A

4 days

139
Q

If a patient comes in asking for tranexamic acid OTC for heavy periods, but is on warfarin/DOAC, what should you do?

A

Refer

Heavy period may be due to anticoagulation

140
Q

What is the supply criteria for sumatriptan OTC?

A
  • > 18 years
  • Needs to have a migraine diagnosis by doctor/pharmacist
  • Established pattern of migraine - history of 5 or more attacks over a period of at least a year
  • Have tried simple analgesia and it hasn’t worked
141
Q

If a patient comes in asking for sumatriptan but is on an SSRI/TCA, what should you do?

A

Refer

Risk of serotonin syndrome if used together

142
Q

If a patient comes in asking for sumatriptan but is on an a MAOI, what should you do?

A

Refer

143
Q

Can sumatriptan be used as a prophylactic for migraines?

A

No- it is for acute attacks

144
Q

What is the supply criteria for tamsulosin OTC?

A

Male patients 45-75 years

  • Had symptoms for a minimum of 3 months
  • 2 weeks supplied initially and then if there is an improvement in symptoms, a further 4 weeks can be supplied
145
Q

How many weeks of tamsulosin is supplied initially?

A

2 weeks

146
Q

After how many weeks of tamsulosin OTC does the patient have to get assessed by a doctor?

A

6 weeks and they can agree whether further supplies are appropriate

Then an annual review after this

147
Q

If a male patient asks for tamsulosin OTC but mentions he suffers from postural hypotension, what should you do?

A

Refer

Can cause postural hypotension

148
Q

What are the dosing instructions for chloramphenicol eye drops?

A

Total 5 days

One drop into affected eye every 2 hours for the first 48 hours and every 4 hours after

149
Q

What are the dosing instructions for chloramphenicol ointment?

What about if used with the eye drops?

A

Apply 3-4 times a day for 5 days

Eye drops during the day, and the ointment just one application at night

150
Q

What are the storage requirements for chloramphenicol

i) Eye drops
ii) Ointment

A

Store eye drops in the fridge

Ointment does not need to be in the fridge but store at no more than 25°C

151
Q

If a patient presents to the pharmacy with bacterial conjunctivitis, but wears contact lenses, what should you do?

A

Refer - needs to be advised chloramphenicol on the advice of a doctor / contact lens practitioner

Hard contact lens users and disposable contact lens users can start using their lenses again after successfully completing a course of treatment.

Soft contact lens wearers should wait 24 hours after completing a course of treatment before starting to use their lenses again.

152
Q

Is it recommended that a child with bacterial conjunctivitis does not go to school?

A

No - should still go to school

153
Q

What is the minimum age for pantoprazole OTC?

A

18 years

154
Q

What is the dose for pantoprazole OTC?

A

20mg OD

155
Q

Do PPIs provide immediate relief?

A

No- start to work after a day or so

If a patient needs immediate relief, an antacid or alginate is more appropriate

156
Q

At what age would you refer a patient if they requested a PPI for first time dyspepsia symptoms?

A

55 years

Refer those over 45 years of age who suffer from long term recurrent symptoms of indigestion or heartburn

157
Q

What is Onychomycosis?

A

Fungal nail infection

158
Q

What is the dosing instruction for amorolfine for fungal nail infections?

What time scale for toenails and fingernails?

A

Apply to the nail once weekly

Has to be applied regularly until all the affected nail has grown out

6 months for fingernails
9-12 months for toenails

159
Q

A non blanching rash can be a symptom of what?

A

Meningitis

The rash does not fade when pressed with a glass

160
Q

How long before symptom onset is chickenpox contagious for?

A

Usually from 2 days before spots appear

Until the spots have crusted over- considered contagious until no new lesions have appeared for 24 hours

161
Q

How soon do you get symptoms after coming into contact with chickenpox?

A

1-3 weeks

162
Q

Can you catch shingles from someone with chickenpox?

A

No

163
Q

Can you catch chickenpox from someone with shingles?

A

Yes if you have not had chickenpox before

164
Q

How may hours after unprotected sex is Ulipristal Acetate licensed for?

A

120 hours (5 days)

165
Q

How may hours after unprotected sex is Levonorgestrel licensed for?

A

72 hours (3 days)

166
Q

What age is levonorgestrel licensed for OTC?

A

16 years and over

167
Q

What is the dose of ulipristal acetate for EHC?

A

30mg

168
Q

What is the dose of levonorgestrel for EHC?

A

1500 micrograms

169
Q

True or false:
Ulipristal EHC is not recommended for patients who have taken CYP3A4 enzyme inducing medicines or herbal products in the last 4 weeks

A

True

170
Q

If a patient has taken CYP3A4 enzyme inducing medicines or herbal products in the last 4 weeks, and an IUD is not suitable, what EHC and what dose should they have?

A

2 tablets of levonorgestrel 1500 micrograms should be taken within 72 hours of unprotected sex

171
Q

Levonorgestrel is less effective in women with a BMI over what?

A

26 - may need a double dose as per FSRH advice

172
Q

What is the advice surrounding EHC levonorgestrel and vomiting?

A

If the patient vomits within 3 hours of taking levonorgestrel, she should repeat the same dose she took previously.

173
Q

Can you take a second dose of levonorgestrel within the same cycle?

A

EMC does not advise it as it can disturb the woman’s period

174
Q

If a patient has taken EHC, after how any days of an overdue period must they do a pregnancy test?

A

More than 5 days overdue

175
Q

What is the advice surrounding EHC ulipristal and vomiting?

A

If vomiting occurs within 3 hours another tablet should be taken as soon as possible

176
Q

In what clinical conditions is the use of EHC ulipristal not recommended?

A

Severe hepatic impairment

Asthma which is being treated by oral glucocorticoids

177
Q

In what clinical conditions is the use of EHC levonorgestrel not recommended?

A

Severe malabsorption syndrome e.g. Crohn’s

Severe hepatic impairment

178
Q

What is the advice regarding ulipristal EHC and breastfeeding?

A

After using ulipristal breast feeding is not recommended for a week because it is present in breast milk.

During this time expressing and discarding the milk is advised to maintain lactation.

179
Q

What is the advice regarding levonorgestrel EHC and breastfeeding?

A

Potential exposure of an infant to levonorgestrel can be reduced if the breast-feeding woman takes the tablet immediately after feeding and avoids nursing at least 8 hours following Levonelle

180
Q

Children under what age are legally too young to consent to sexual activity?

A

13 years

181
Q

What is the dosing instruction for naproxen OTC for painful periods?

A

On the first day 2 tablets (500 mg) should be taken initially and then one tablet (250 mg) after 6 to 8 hours if needed.

Max 3 tablets in a day

Max number of days for treatment is 3 days

182
Q

What is the max duration of days is licensed for OTC naproxen for painful periods?

A

3 days

183
Q

Viagra OTC is licensed from what age?

A

18 years

184
Q

What is the dosing instruction for Viagra?

A

One 50 mg tablet taken with water approximately one hour before sexual activity - max of one tablet in 24 hours

If Viagra Connect is taken with food, the onset of activity may be delayed compared to the fasted state

185
Q

If a patient presents to the pharmacy with subconjuctival haemorrhage, what you recommend??
What would warrant a referral?

A

There should be no pain and the patient should be reassured that symptoms will resolve in 10 to 14 days without treatment. However, a patient with a history of trauma should be referred to exclude ocular injury.

186
Q

Psuedoephedrine is cautioned in what conditions?

A

Diabetes
Hypertension
Heart disease
Angle-closure glaucoma

187
Q

Miss W is a 19 year old patient who has developed several painful red lumps and patches (that measure 1-5 cm) on her lower legs

What advice should you give?

A

These lumps are characteristic of erythema nodosum. Treatment is usually rest and painkillers such as NSAIDs.

  • The bumps and patches last about two weeks before fading like a bruise.
188
Q

How many levels of healthy living pharmacy is there?

A

Level 1, 2 and 3

Need to be on the HLP register

189
Q

What does Level 1, 2 and 3 healthy living pharmacies entail?

A

Level 1- Promoting health, wellbeing and self-care (profession-led)

Level 2 - Providing services (commissioner-led)

Level 3 - Providing treatment (commissioner-led)

190
Q

What is the dose of paracetamol for a 2 month old?

A

30-60mg TDS

191
Q

What is the dose of paracetamol for 3-5 months?

A

60mg QDS

192
Q

What is the dose of paracetamol for 6 months-2 years?

A

120mg QDS

193
Q

What is the dose of paracetamol for 2-3 years?

A

180mg QDS

194
Q

What is the dose of paracetamol for 4-5 years?

A

240mg QDS

195
Q

What is the dose of paracetamol for 6-7 years?

A

250mg QDS

196
Q

What is the dose of paracetamol for 8-9 years?

A

375mg QDS

197
Q

What is the dose of paracetamol for 10-11 years?

A

500g QDS

198
Q

What is the dose of paracetamol for 12-15 years?

A

480-750mg QDS

199
Q

Discharge coming out the ear can indicate what?

A

Ear infection- refer

200
Q

A patient has severe itchy hands, particularly at night. You notice silver lines with a dot at the end in the webs of her fingers.

What is this?

A

Scabies

201
Q

Which illness is characterised by white spots surrounded by a red ring on the inner cheek and gums?

A

Measles

202
Q

Rubella is also known as what?

A

German measles

203
Q

The difference between German measles and measles (morbilli) is what?

A

Measles manifests itself with white spots in the mouth.

204
Q

What are the symptoms of Reye’s Syndrome?

A
  • Vomiting repeatedly
  • Tiredness and lack of interest or enthusiasm
  • Rapid breathing
  • Seizures

As the condition progresses, the symptoms may get more severe and more wide-ranging, and can include:

  • Irritability, or irrational or aggressive behaviour
  • Severe anxiety and confusion that’s sometimes associated with hallucinations
  • Coma (loss of consciousness)