Osteoporosis Tx (from lecture)

Question 1

*disclaimer: i haven’t looked at pharm so I don’t actually know if any of these drugs are in the pharm tables but I’m assuming they are

Answer 1

but I know wall just loves to put pharm on clin med exams!

Question 2

what are the instructions for taking the bisphosphonate Fosomax?

Answer 2

take 30min before AM meal with 8oz water and remain upright 30min to prevent esophagitis

Question 3

which drug class can cause a side effect of “acute phase syndrome” within 1-2 weeks

Answer 3

bisphosphonates

Question 4

which drug class may increase the risk of unusual “chalkstick” femur fx?

Answer 4

bisphosphonates

Question 5

which treatment is given for women with premature menopause and is given short-term?

Answer 5

estrogen

Question 6

which drug arrests bone loss?

Answer 6

Vit D + Ca

Question 7

which drug has a T1/2 of 10 years, so can only be prescribed for 5 years?

Answer 7

bisphosphonates

Question 8

what drug class does Evista belong to?

Answer 8

SERMS

Question 9

what drug is given to people who can’t tolerate other drugs?

Answer 9

denosumab

Question 10

which drug class is less effective than estrogen but has decreased risks of endometrial and breast cancer?

Answer 10

SERMS

Question 11

What drug has paradoxical effects when given intermittently and actually leads to new bone formation?

Answer 11

PTH analogues (e.g. teriparatide)

Question 12

what drug is a nasal spray?

Answer 12

calcitonin

Question 13

with which drug class is dental care important?

Answer 13

bisphosphonates

Question 14

what drug accelerates bone Ca absorption and increases bone strength?

Answer 14

calcitonin