Osteoporosis Drugs Flashcards
Biphosponates
MOA: impedes bone resorption by inhibiting osteoclastic activity –> absorbing Ca phosphate in bone
- Alendronate: daily or weekly tablet- empty stomach
- Ibandronate: monthly tablet- empty stomach; IV infusion every 3 weeks
- Risedronate: daily or weekly tablet- empty stomach
- Zolendronate: annual IV infusion
SE: GI disturbances, dysphagia, inflammation of esophagus
-Zolendronate: A-fib
Calcitonin
Miacalcin, Fortical
MOA: dec osteoclastic activity in bone, dec mineral release and collagen breakdown in bone, assists with renal excretion of Ca
intranasal spray daily, SQ injection available
SE: rhinitis, epistaxis rare
Estrogen/Hormone Therapy
Estrace, Estraderm, Premarin
MOA: assists with bone remodeling and osteoclastic activity
varied methods of admin
SE: DVT, MI, stroke, breast cancer, PE
Estrogen Agonist/Antagonist (selective estrogen receptor modulator, SERM)
Raloxifene
MOA: assists with bone remodeling and osteoclastic activity
daily tablet
SE: DVT
Parathyroid Hormone
PTH (1-34), Forteo
MOA: protect against gonadatropin-releasing hormone agonist-related bone loss
SQ injection daily
SE: leg cramps, dizziness
Parathyroid Hormone Analog
Abaloparatide (Tymlos)
MOA: inc bone density and strength
periumbical SQ injection daily
SE: dizziness, tachycardia
Dual-acting Bone Agent
Strontium ranelate
MOA: dec osteoclastic activity and inc osteoblastic activity –> balancing bone turnover, inc bone formation/remodeling
daily soluble sachet
non-FDA approved
Monoclonal activity
Denosumab
MOA: inhibits osteoclastic function, formation, and survival –> reducing osteoclastic bone resorption
SQ injection every 6 months
non-FDA approved
can be used with patients that cannot take biphosphonates or those with reduced renal function
causes infections
