HIV Drugs

Question 1

NRTI

Answer 1

Tenofovir, Abacavir, Zidovudine

MOA: prevent viral RNA from becoming viral DNA by inhibiting reverse transcriptase

SE: lactic acidosis, dec bone density

Question 2

NNRTI

Answer 2

Etravirine, Efavirenz, Nevirapin

MOA: prevent viral RNA from becoming viral DNA by inhibiting reverse transcriptase

SE: lipodystrophy

Question 3

Protease Inhibitors

Answer 3

Darunavir, Alazanavir (Reyataz), Ritonavir

MOA: prevent functional viral proteins from assembling into a new virus

SE: DM, hyperlipidemia

Question 4

Fusion Inhibitors

Answer 4

Enfuvirtide

MOA: prevent the HIV virus from entering target cells

SE: injection site reaction

Question 5

CCR5 Antagonists

Answer 5

Maraviroc

MOA: prevent the HIV virus from entering target cells by blocking receptors

SE: hepatitis

Question 6

Integrase Inhibitors

Answer 6

Raltegravir, Dolutegravir

MOA: prevent integration of viral DNA into the T cell’s DNA

SE: elevated amylase or LFTs

Dolutegavir: neural tube defects

Question 7

Post-attachment inhibitors

Answer 7

Ibalizumab

MOA: blocks CD4+ receptors on certain immune cells

SE: diarrhea, rash