Osteoporosis Flashcards

1
Q

What is osteoporosis?

A

Systemic skeletal disease which is characterised by low bone mass and microarchitectural deterioration of bone tissue

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2
Q

What does osteoporosis increase your chance of?

A

Fractures due to increased bone fragility

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3
Q

What does osteoporosis mean?

A

Reduced bone mass

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4
Q

What does osteomalacia mean?

A

Normal bone mass but reduced mineral content

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5
Q

What changes to the bone occur?

A
  • Fewer trabeculae
  • Thinning of cortical bone
  • Widening of haversian canal
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6
Q

Which bones are more prone to fracture and why?

A

Vertebrae, shoulder blades and ribs as they are mainly spongy bone

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7
Q

What are the risk factors for osteoporosis?

A
S - steroids 
H - hyperthyroidism, hyperparathyroidism, hypercalciuria 
A - alcohol 
T - thin (BMI < 18.5) 
E - early menopause 
R - renal or liver failure 
E - erosive/ inflammatory bone disease 
D - Dietary disease
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8
Q

What are the signs of osteoporosis?

A
  • Dowagers hump (crush fractures of vertebrae) if trabecular bone is affected
  • Fractures (especially hip) if cortical bone is affected
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9
Q

What would you use to diagnose osteoporosis?

A

Xray

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10
Q

What would you not be able to detect on an xray?

A

Osteopenia

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11
Q

What is a DEXA scan?

A

Measures the bone mineral density

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12
Q

What is a T score?

A

The results of the DEXA scan. A standard deviation score compares with gender match young adult average (peak bone mass)

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13
Q

What would a T score of between -1 and -2.5 indicate?

A

Osteopenia

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14
Q

What does a T score of -2.5 indicate?

A

Osteoporosis

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15
Q

What would a a score of

A

Sever osteoporosis

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16
Q

What are the non-pharmalogical methods for treatment?

A
  • Stop smoking and reduce alcohol
  • Weight bearing exercises
  • Balance exercises
  • Calcium and vitamin D rich diet
17
Q

What do anti-resorptive medications do?

A

Decrease osteoclast activity and bone turnover

18
Q

Given an example of groups of anti-resorptive treatments?

A
  • Bisphosphonates
  • HRT
  • Denosumab
19
Q

What is denosumab?

A

A monoclonal antibody to RANK ligand

20
Q

What do anabolic treatments do?

A

Increase osteoblast activity and bone formation

21
Q

Give an example of an anabolic treatment?

A

Teriparatides