Osteoarthritis Flashcards

1
Q

What is osteoarthritis characterized by?

A

Progressive destruction and loss of articular cartilage with an accompanying bone response

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2
Q

What type of joint is it the most common condition to affect?

A

Synovial joints

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3
Q

Which tissues in the joint are affected?

A

All the tissues

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4
Q

What part is most affected?

A

Articular cartilage

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5
Q

What type of process is osteoartheritis?

A

Metabolically active and dynamic which is mediated by cytokines

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6
Q

What are the main pathological features?

A
  • Loss of cartilage

- Disordered bone repair - attempts repairs and develops osteophytes

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7
Q

What joints does OA most commonly affect in the hands?

A

PIP, PIP, Carpometacarpal joints - its spares the MCP joints usually

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8
Q

What are the bony swellings at the DIP and PIP joints called?

A
DIP = Heberden's nides 
PIP = Bouchard's nodes
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9
Q

What compartment of the knee is most affected?

A

Medial

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10
Q

Where is OA in the hip usually felt?

A

In the groin

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11
Q

Why is age a risk factor for OA?

A
  • Cumulative effect of traumatic insult

- Decline in neuromuscular function

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12
Q

Apart from age what else is a risk factor for OA?

A
  • Female
  • Genetic predisposition
  • Obesity
  • Occupational
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13
Q

What are the signs of OA?

A
  • Alteration in gait
  • Joint swelling (bony enlargement, effusion, synovitis)
  • Limited range of movement
  • Deformities
  • Tenderness
  • Locking of the knee due to loose bodies
  • Bony swelling (herberdens at DIP, bounchards at PIP)
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14
Q

What are the symptoms of OA?

A
  • Pain
  • Functional impairment
  • Tenderness
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15
Q

What radiological features are seen in OA?

A
L - Loss of joint space 
O - Osteophyte formation 
S - Subcondral sclerosis 
S - Subcondral cysts
A - Abnormalities of bone contour (gull wing appearance)
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16
Q

What would you see on the FBC in OA?

A

CRP might be slightly elevated, but should be mostly normal. ESR is normal.

17
Q

What would an MRI show in OA?

A

Early cartilage changes

18
Q

What is the non-medical treatment for OA?

A
  • Patient education
  • Activity and exercise
  • Weight loss
  • Physio
  • Footwear
19
Q

What pharmacological treatment can be used in OA?

A
  • Topical analgesia
  • Oral analgesia
  • Transdurmal patches
  • Intra-articular steroid injections
  • Intra-articular hyaluronic acid injection
  • DMARDs
20
Q

What alternative therapies can be used?

A
  • Glucosamine
  • Chondroitin
  • Nettle extract
  • Turmeric
  • Chinese Herbal Medicine
21
Q

What surgical options are there for OA?

A
  • Arthroscopy (loose bodies)
  • Osteotomy - bone is cut in order to shorten and realign better
  • Arthroplasty (replacement)
  • Fusion