Osteoporosis Flashcards

1
Q

which bisphosphonate show efficacy at ONLY the vertebrae

A

ibandronate

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2
Q

what drugs are approved/ok for men to use

A

alendronate, risedronate, zoledronate, denosumab, teriparatide

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3
Q

what is the one drug that was talked about where it does NOT show effiacy at the vertebrae

A

Duavee (bazedoxifene, estrogen)

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4
Q

which drugs show efficacy at the hip

A

alendronate, risedronate, zoledronate, denosumab

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5
Q

which drugs show efficacy at the hip, vetebrae, and non-vetebrae areas?

A

alendronate, risedronate, zoledronate, denosumab

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6
Q

where does teriparatide show efficacy at?

A

vetebrae and non-vertebrae

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7
Q

where does abaloparatide show efficacy at?

A

vetebrae and non-vertebrae

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8
Q

where does ibandronate show efficacy at?

A

vetebrae

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9
Q

what is the contraindication for denosumab

A

hypocalemia

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10
Q

what is the indication for Salmon-Calcitonin

A

TREATMENT of POSTMenopausal osteoporosis in women that have had menopause for MORE than 5 YEARS

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11
Q

Calcitonin shows efficacy where?

A

Vetebrae

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12
Q

Raloxifene shows efficacy where?

A

Vertebrae

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13
Q

where does denosumab show effiacy?

A

hip, vetebrae, non-vertebrae

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14
Q

Maximum lifetime duration of parathyroid hormone drugs

A

2 years

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15
Q

Parathyroid Hormone Drug ADE’s are …?

A
  • Orthostatic hypotension, dizziness,
  • Leg cramps, Joint Pain
  • HYPERCALCEMIA and HYPERCALCIURIA (risk of kidney stones and reduce calcium intake to less than 1000 mg/day)
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16
Q

where do the parathyroid hormone drugs show efficacy?

A

vertebrae and Non-vertebrae

17
Q

Contraindications for bisphosphonates

A
  • Hypocalcemia
  • esophageal abnormalities
  • Renal Insufficiency
  • Inability to sit up for 30 mins (or 60 mins) after administration
  • Pregnant/Breast feeding
18
Q

Drug Interactions with Oral bisphosphonates

A
  • it will chelate with multivalent cations (antacids, mineral supplements, vitamins, osmotic laxatives (but not magaldrate, sodium bicarb)
  • Increase in GI side effects with NSAIDs