Osteoporosis Flashcards
1
Q
what are iatrogenic causes of osteoporosis
A
- steroids
- some anti- epileptic agents
- anticoagulants
- PPI’s (proton pump inhibitors)
- thiazolidinediones
- lithium (anti psychotic)
2
Q
what is the suffix for osteoporosis meds
A
-“dronate”
3
Q
what is the indication of alendronate
A
- osteoporosis
2. Paget’s disease
4
Q
what is the MOA of alendronate
A
these drugs get ingested by osteoclasts, and when they do HMG-CoA reductase is inhibited which leads to cell death and causes reduced bone resorption and turnover (bisphosphonate)
5
Q
what inhibits all key products that are responsible for fueling all three pathways
A
bisphosphonates
6
Q
what are AE of alendronate
A
photosensitivity
7
Q
what are serious AE of alendronate
A
- angioedema
2. uveitis, scleritis (impt!)
8
Q
what are drug interactions of alendronate
A
NSAIDS: additive GI irritation
