Cancer Flashcards
What are the two most common lethal cancers in men and women
- breast cancer
- lung cancer
* both most likely of all cancers to metastasize to the eye
what do newer targeted therapeutic agents include
tyrosine kinase inhibitors and monoclonal antibodies.
what are the most widely used cytostatics that masquerade as nucleic acid bases and disrupt DNA/RNA synthesis, halting cell division.
anti metabolites
typically, wherever you see antibodies is where the ____is and where they would aim radiation therapy
antibodies
what is the #1 cause of death in women and men
lung cancer
what is the #2 cause of death in women and men
women: breast cancer
men: prostate cancer
3 cause of cancer in men and women is:
colon and rectum
what are the two anti metabolites discussed in class
- methotrexate
2. pemetrexed
what is the indication of methotrexate
- Rheumatoid arthritis
- psoriases
- choriocarcinoma
what is the MOA of methotrexate
- acts as a folic acid analogue, inhibits dihydrofolate reductase which prevents formation of tetrahydrofolate.
- inhibits lymphocyte proliferation
- anti inflammatory effects mediated by activation of adenosine pathways.
what are common AE of methotrexate
- photosensitivity
- pruritius
- anemia
- dizziness
what are severe AE of methotrexate
neurotoxicity
what is a BB warning of methotrexate
- potentially fatal myelosuppression with NSAIDS
- deaths reported: monitor bone marrow, liver, lung & kidneys –> opportunistic infections.
what are drug interactions of methotrexate
- NSAIDs, sulfonamides, ciprofloxacin, penicillins: reduced renal elimination
- tetracyclines: elevated levels
- cyclosporine: reduced hepatic metabolism
- ganciclovir: additive myelosuppression
- systemic corticosteroids: additive immunosuppression
