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Endocrino > Osteoporosis > Flashcards

Osteoporosis Flashcards

1
Q

Características de la osteoporosis

A

Baja densidad osea y deterioro microarquitectonico

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2
Q

Fracturas mas frecuentes en osteopororsis

A

Femur proximal, vertebras y radio distal

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3
Q

Osteopororosis mas comun

A

Por deficiencia de estrogenos

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4
Q

Factor de riesgo de fractura

A

Mujer de mas de 50 años postmenopausica

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5
Q

que hacen los osteoclastos?

A

Absorben el hueso

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6
Q

Funcion de los osteoblastos

A

Forman hueso

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7
Q

Principal proteina de los osteoblastos

A

Colageno tipo 1

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8
Q

Que es la fase inicial de perdida osea

A

Dura de 3-5 años y hay una perdida rapida del hueso trabecular

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9
Q

Cual es la segunda fase de perdida osea?

A

Perdida mas lenta que dura de 10-20 añis en hombres y mujeres mayores e involucra el hueso cortical y trabecular.

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10
Q

Como se producen los estrogenos residuales

A

Por la conversion de androgenos suprarrenales por la enzima aromatasa

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11
Q

Receptores ERa

A

Hueso cortical

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12
Q

Receptores ERb

A

Hueso trabecular

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13
Q

Funciones necesarias para la funcion de los osteoblastos

A

Proteína morfogenetica osea, TGFbeta y la via de señalizacion canonica WNT.

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14
Q

Que modulan los estrogenos?

A

Activador del receptor del ligando NF-KB y la via de la osteoprotegerina

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15
Q

Funcion de los osteocitos

A

Son mecanosensores y afinan la remodelacion osea mediante ostebolastos y osteoclastos

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16
Q

Derivacion de los osteoblastos

A

Celulas mesenquimales

17
Q

Proceso de los osteoblastos

A

Producir matriz osea, que se mineraliza y endurece mediane al deposito de hidroxiapatita

18
Q

Que se encarga del endurecimiento de la matriz osea?

A

Depositos de hidroxiapatita de calcio

19
Q

De dode derivan los osteoclastos?

A

Celuas hematopoyeticas

20
Q

Que secretan los osteoclastos?

A

HCI

21
Q
A

Endocrino (7 decks)

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