OSTEOPORIS

Question 1

KRITERIA WHO

Answer 1

BMD PADA LUMBAL DAN PINGGUL <2.5

Question 2

lokasi paling sering tjdnya osteoporosis adalah

Answer 2

vertebrae,proximal femur,distal antebrachii,pinggul

Question 3

faktor osteoporosis

Answer 3

umur,hipogonad,menopause,high bone turn over

Question 4

faktor gangguan haematogic adalah

Answer 4

hemophilia,multiple myeloma,thalasemia,leukimia

Question 5

obat obatan yang mempengaruhi osteoporosis

Answer 5

antasida,aromatase inhibitor,depo-medroxzyprogesterone,lithium cyclosporin,tacrolimus,tamoxifen,methotrexat,barbiturate,glukokortikoid,antikoagulan,

Question 6

diagnosis osteopenia

Answer 6

1.0-2.5

Question 7

diagnosis bmd

Answer 7

<2.5

Question 8

tujuan utama pharmacology terapi

Answer 8

prevensi fraktur

Question 9

apa asaja farmako osteoporosis

Answer 9

biphosphate,SERT,HRT,calcitonin,vit d, paratyhorid hormon

Question 10

indikasi BMD

Answer 10

64 WANITA, 70 LAKI

Question 11

farmakokinetik biphosponate

Answer 11

absorpsi pada saluran cerna hanya 10% shg 80%nya lgsg diserap di tulang

Question 12

golongan 1 biphosponate

Answer 12

etidronate,clodronate

Question 13

golongan 2 biphoponate

Answer 13

tiludronate,pamidronate,aledronate

Question 14

golongan 3 biphosponate

Answer 14

risedronate,ibandronate,zoledronate

Question 15

mekanisme kerja biphosponate

Answer 15

menurunkan progenitor osteoklas,osteoklas di apoptosis,menurunkan kerja osteoklas, antiapoptotik pada osteoblast

Question 16

alendronate diberi

Answer 16

preventif : 5mg/hari
treatment : 10 mg/hari
dgn 5600iu vit d

Question 17

ibandronate diberi

Answer 17

150mg stiap bulan, 3 mg stiap 3 bulan iv

Question 18

ES biposphonate

Answer 18

sulit menelan,gangguan saluran cerna,inflamasi esofagus dan lambung, karena biphosponate bikin iritasi, mempengaruhi ginjal

Question 19

calcitonin berfungsi

Answer 19

mempengaruhi metabolisme kalsium dlm tubuh

Question 20

dosis calcitonin

Answer 20

200iu injeksi subkutan

Question 21

es calcitonin

Answer 21

risk cancer

Question 22

estrogen/hormone therapy bersifat

Answer 22

efek proteksi thd osteoporosis karena menjaga proses resorpsi

Question 23

es estrogen hormone therapy

Answer 23

myocardial infark,stroke,ca mammae

Question 24

contoh SERMS

Answer 24

RALOXIFENE

Question 25

serms digunakan untuk

Answer 25

wanitan menopause

Question 26

ES serms

Answer 26

DVT

Question 27

CONTOH PARATYHROID HORMONE

Answer 27

TERIPATIDE

Question 28

paratyhroid hormone diberikan dengan

Answer 28

injekaeksi subkutan

Question 29

calcitriol berkeja dengan

Answer 29

mempengaruhi kalsium

Question 30

manfaat calcitrol

Answer 30

meningkatkan bmd, menurunkan tingkat fraktur, menormalkan absorpsi kalsium, mengurangi resiko jatuh