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MUSKULOSKELETAL > OSTEOPORIS > Flashcards

OSTEOPORIS Flashcards

1
Q

KRITERIA WHO

A

BMD PADA LUMBAL DAN PINGGUL <2.5

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2
Q

lokasi paling sering tjdnya osteoporosis adalah

A

vertebrae,proximal femur,distal antebrachii,pinggul

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3
Q

faktor osteoporosis

A

umur,hipogonad,menopause,high bone turn over

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4
Q

faktor gangguan haematogic adalah

A

hemophilia,multiple myeloma,thalasemia,leukimia

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5
Q

obat obatan yang mempengaruhi osteoporosis

A

antasida,aromatase inhibitor,depo-medroxzyprogesterone,lithium cyclosporin,tacrolimus,tamoxifen,methotrexat,barbiturate,glukokortikoid,antikoagulan,

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6
Q

diagnosis osteopenia

A

1.0-2.5

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7
Q

diagnosis bmd

A

<2.5

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8
Q

tujuan utama pharmacology terapi

A

prevensi fraktur

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9
Q

apa asaja farmako osteoporosis

A

biphosphate,SERT,HRT,calcitonin,vit d, paratyhorid hormon

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10
Q

indikasi BMD

A

64 WANITA, 70 LAKI

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11
Q

farmakokinetik biphosponate

A

absorpsi pada saluran cerna hanya 10% shg 80%nya lgsg diserap di tulang

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12
Q

golongan 1 biphosponate

A

etidronate,clodronate

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13
Q

golongan 2 biphoponate

A

tiludronate,pamidronate,aledronate

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14
Q

golongan 3 biphosponate

A

risedronate,ibandronate,zoledronate

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15
Q

mekanisme kerja biphosponate

A

menurunkan progenitor osteoklas,osteoklas di apoptosis,menurunkan kerja osteoklas, antiapoptotik pada osteoblast

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16
Q

alendronate diberi

A

preventif : 5mg/hari
treatment : 10 mg/hari
dgn 5600iu vit d

17
Q

ibandronate diberi

A

150mg stiap bulan, 3 mg stiap 3 bulan iv

18
Q

ES biposphonate

A

sulit menelan,gangguan saluran cerna,inflamasi esofagus dan lambung, karena biphosponate bikin iritasi, mempengaruhi ginjal

19
Q

calcitonin berfungsi

A

mempengaruhi metabolisme kalsium dlm tubuh

20
Q

dosis calcitonin

A

200iu injeksi subkutan

21
Q

es calcitonin

A

risk cancer

22
Q

estrogen/hormone therapy bersifat

A

efek proteksi thd osteoporosis karena menjaga proses resorpsi

23
Q

es estrogen hormone therapy

A

myocardial infark,stroke,ca mammae

24
Q

contoh SERMS

A

RALOXIFENE

25
Q

serms digunakan untuk

A

wanitan menopause

26
Q

ES serms

A

DVT

27
Q

CONTOH PARATYHROID HORMONE

A

TERIPATIDE

28
Q

paratyhroid hormone diberikan dengan

A

injekaeksi subkutan

29
Q

calcitriol berkeja dengan

A

mempengaruhi kalsium

30
Q

manfaat calcitrol

A

meningkatkan bmd, menurunkan tingkat fraktur, menormalkan absorpsi kalsium, mengurangi resiko jatuh

MUSKULOSKELETAL (12 decks)

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