Osteoarthritis Pathophys/Pharmacotherapy

Question 1

Osteoarthritis is the progressive destruction of __ cartilage

Answer 1

articular

Question 2

Joint __ occurs due to loss of cartilage leading to deformed joints

Answer 2

narrowing

Question 3

4 inflammatory agents in synovial fluid:

Answer 3

IL-1
PGE2
TNF alpha
nitric oxide

Question 4

Changes to the __ bone also occur in osteoarthritis leading to denuded bone from eburnation

Answer 4

subchondral

Question 5

4 steps of osteoarthritis pathophys:

AIBL

Answer 5

A - articular cartilage damage
I - increased chondrocyte activity
B - breakdown and resynthesis balance lost
L - loss of cartilage leading to deformity

Question 6

What type of osteoarthritis has no identifiable cause?

primary or secondary

Answer 6

primary

most common

Question 7

3 lab findings for OA:

Answer 7

• ESR
• RF factor negative
• WBC in synovial fluid

Question 8

What drug class is the mainstay of OA management?

Answer 8

nsaids

Question 9

Caution with nsaids in what two pt populations?

Answer 9

renal impairment

pregnancy (third trimester)

Question 10

What nsaid is CI in pts allergic to sulfa?

Answer 10

celecoxib

Question 11

Acetaminophen is __ recommended for pts with knee, hip, and/or hand OA

a. strongly
b. conditionally

Answer 11

b. conditionally

Question 12

Corticosteroids (intraarticular) are strongly recommended for knee and/or hip OA

a. true
b. false

Answer 12

a. true

conditionally recommended for hand OA

Question 13

Two steroids for OA?

Answer 13

triamcinolone acetonide (10-40mg IA)
metylprednisolone acetate (20-80mg IA)

Question 14

Capsaicin is conditionally recommended for OA in what joint?

Answer 14

knee

Question 15

What SNRI is used for OA?

Answer 15

duloxetine

conditionally recommended for knee, hip, hand OA

Question 16

What opioid is conditionally recommended for knee, hip, hand OA?

Answer 16

tramadol