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7262 MS Block 2 > Drug Induced Lupus > Flashcards

Drug Induced Lupus Flashcards

1
Q

Drug induced lupus resolves with drug d/c

a. true
b. false

A

a. true

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2
Q

Drug induced lupus occurs most often in what pt population?

A

older Caucasian pts

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3
Q

There are no standard diagnostic criteria for drug induced lupus.

a. true
b. false

A

a. true

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4
Q

___ has higher rates in African American and Asian pts

a. SLE
b. drug induced lupus

A

a. SLE

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5
Q

Renal and psychiatric Sx are rare with drug induced lupus

a. true
b. false

A

a. true

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6
Q

What age range is onset of drug induce lupus?

A

50s to 70s

SLE is 20s to 40s

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7
Q

__ antibodies are present in 96% of drug induced lupus pts

A

histone

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8
Q

99% of drug induced lupus pts have positive what?

A

ANA

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9
Q

Systemic Sx of drug induced lupus?

A

fever
malaise
arthritis/arthralgias/myalgias
serositis

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10
Q

Which of the following statements regarding drug induced lupus is false?

a. occurs in 10% of SLE cases in the US
b. involves multiple organ systems
c. typically affects young African American pts
d. can occur months to years after starting causative drug

A

c. typically affects young African American pts

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11
Q

Drugs that can cause drug induced lupus?

Pills Inflame Hips and Make Me Quite tired

A 
P - procainamide
I - isoniazid
H - hydralazine
M - minocycline
M - methyldopa
Q - quinidine
T - TNF alpha inhibitors
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12
Q

__ is mostly associated with musculoskeletal Sx (arthralgia , arthritis, myalgia)

A

procainamide

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13
Q

Slow acetylators are a risk factor for __ induced lupus

A

procainamide

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14
Q

Hydralazine doses of > __ mg per day or cumulative dose of __ g can cause lupus

A

200, 100

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15
Q

What drug class is associated with cutaneous and musculoskeletal Sx?

A

TNF alpha inhibitors

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16
Q

3 TNF alpha inhibitors that can cause lupus:

A

etanercept
infliximab
adalimumab (lower incidence)

17
Q

What drug usually causes lupus in younger pts and is associated with musculoskeletal and hepatic Sx?

A

minocycline

18
Q

Which of the following TNF alpha inhibitors have not been shown to cause drug induced lupus?

a. etanercept
b. erlotinib
c. infliximab
d. adalimumab

A

b. erlotinib

19
Q

Management for drug induced lupus?

A

d/c offending agent and do NOT rechallenge

20
Q

There is no difference in drug induced lupus between the sexes.

a. true
b. false

A

a. true

7262 MS Block 2 (10 decks)

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