Osteoarthritis and osteochrondritis dissecans Flashcards
_____ joins bones with a fibrous joint capsule that is continuous with the periosteum of the joined bones
synovial joint
_____ permits motion while providing stability for load transfer b/t bones
synovial joints
Hips, stifle, elbow and shoulder are examples of _____ joints
synovial
Synovial joints are made up of what type of cartilage?
hyaline/articular cartilage
T/F: Hyaline/Articular cartilage is highly vascular
FALSE: relatively avascular
Where do joints get their nutrients?
synovial fluid
Is osteoarthritis inflammatory?
No- non inflam degenerative joint disease
What are the three factors of osteoarthritis (non-inflam DJD)?
articular cartilage degeneration
marginal bone hypertrophy, aka osteophytosis
synovial membrane changes4
T/F: Dysplasia, DJD, trauma and neoplasia are examples of inflammatory arthropathy
FLASE- non inflammatory
Inflammatory causes
infectious: bact, viral, rickettsia, fungi, mycoplasms, protozoa, spirochetes
non-infectious: erosive vs nonerosive
Inflammatory non-infectious causes of arthopathy
erosive: rheumatoid, feline chronic progressive polyarthritis
nonerosive: immune-mediated polyarthritis, chronic inflam induced polyarthritis, systemic lupus erythematosus
Diagnosis of osteoarthritis
history and clinical signs: acute vs chronic, dog vs cat
physical exam: muscular asymmetry, joint enlargement, CREPI
What does CREPI stand for?
Crepitus (cracking/crunching when moving joint)
Range of motion
Effusion
Pain
Instability
What are the risk factors for osteoarthritis?
Size and growth rate: 45% of OA dogs are large breeds
Breed and genetics: labs & german shepards are predisposed
Advanced age: 50% of OA dogs are 8 to 13 years old
Obesity
Repeated trauma & mechanical stress
Clinical signs of mild osteoarthritis (OA)
dogs: stiffness, decreased activity, limping
cats: decreased activity
Clinical signs of moderate OA
dogs: pain, muscle atrophy, difficulty rising
cats: reluctance to jump, climb stairs, groom
Clinical signs of severe OA
dogs: loss of range of motion, vocalization, creptius, lethary, inappetence
cats: limping, muscle atrophy, inappropriate elimination
OA radiographic changes for inflammatory/infectious
subchondral bone may be sclerotic or lytic
+/- periarticular bone formation
+/- joint space narrowing
+/- capsule distension and soft tissue swelling
OA radiographic changes for noninfectious- nonerosive
soft tissue swelling and joint capsule w/o bony changes- multiple joints affected
OA radiographic changes for noninfectious- erosive
joint space collapse
subchondral bone proliferation
periosteal new bone production
soft tissue swelling
-multiple joints affected
OA radiographic changes in non inflammatory DJD
soft tissue swelling & intracapsular distension
diminished joint space
periarticular osteophytosis
subchondral bone plate usually intact but may be sclerotic
OA radiographic changes in non inflammatory- trauma
depends on trauma (fracture luxation)
ultimately leads to DJD
OA radiographic changes in non inflammatory- neoplasia
soft tissue swelling and intracapsular distension
destruction of the subchondral bone plate (often on both sides of the joint) with aggressive bone proliferation
What testing can we use to diagnose osteoarthritis (OA)?
computed tomography (CT) -bony changes
MRI- evaluate soft tissue structure: tendons and ligaments
ultrasound
bone scintigraphy
T/F: bone scintigraphy diagnoses OA
FALSE- it localizes OA
(radioactive isotope specific for inflam w/in a joint)
What can differentiate b/t inflammatory Vs non-inflammatory arthropathies?
Joint tap/Joint fluid analysis
looking at the cellular content
inflam has neutrophils
List some examples of OA medical management
weight management
nutritional supplements
exercise moderation
physical rehabilitation
anti-inflam medications and other pain management
What types of nutritional supplements are good for management of OA?
omega 3 fatty acids- anti inflam
chrondroprotectants- glucosamine/chondroitin and ASU (avocado soybean unsaponifiables)
What type of exercise is recommended for P with OA?
low impact activity
leash walks, swimming, hill work
Physical therapy options for OA
stregth
endurance
range of motion
laser therapy
List some options for pain management of OA
NSAIDs- want to spare the kidneys and stomach (COX-1, COX-2, EP4 blockers)
Corticosteroids NOT recommended with DJD
PSGAGs
Acupuncture
Osteochondrosis is a disturbance in _____ that leads to _____
endochondral ossification
cartilage retention/thickening