Osteoarthritis

Question 1

• Most common form of arthritis

• Joint pain and loss of fxn

• Leading source of physical disability with severely impacted QoL

Answer 1

OA

Question 2

PAST description

Answer 2

degenerative “wear and tear”

Question 3

11th most debilitating dse worldwide

Increases after 50 yo
Levels off after 70 yo

Answer 3

OA

Question 4

• Age
• Joint injury
• Obesity
• Genetics
• Anatomical factors (joint space, ligaments, sex)

Answer 4

OA Risk Factors (AJOGA)

Question 5

• Knees
• Hands
• Feet
• Hips
• Spine

Answer 5

COMMON AFFECTATIONS

Question 6

TRIAD OF SYMPTOMS (PJL)

Answer 6

PJL

• Pain
• Joint stiffness <30 mins
• Locomotir restriction/limitation of movements

Question 7

OA Appearance (SDM)

Answer 7

SDM

• Swelling
• Deformity
• Muscle Wasting

Question 8

GOALS OF OA MNGT (MOM)

Answer 8

MOM

• Minimize pain
• Optimize function
• Modify the process of jt damage

Question 9

Effective as NSAIDs in controlling pain, but no anti-inflammatory effects

Answer 9

ACETAMINOPHEN

Question 10

Used if one or a few joints affected, especially knee and/or hand OA

Answer 10

TOPICAL NSAIDS

Question 11

For inadequate symptom relieft from topical NSAIds, symptomatic OA in multiple joints, and/or patients with hip OA

Answer 11

• Oral NSAIDs (lowest dose)
• COX-2 selective NSAID
• nonselective NSAID + proton pump inhibitor (px w comorbid)

Question 12

Pharmacologic Therapy

Answer 12

• Oral and topical NSAIDs
• Topical capsaicin, duloxetine
• Intraarticular glucocorticoids

Question 13

Key ingredients for production of several components of articular cartilage and synovial fluid

Answer 13

Glucosamine and Chrondoitin Sulfate