Adrenergic Drugs Flashcards
Drugs that activate adrenergic receptors
Sympathomimetics
Enhancing the release or blocking reuptake of NE
Indirect-acting agonists
Drugs that block activation of adrenergic receptors
Sympatholytics
Release norepinephrine as the primary neurotransmitter
Adrenergic neurons
Adrenergic receptors
Adrenoceptors
Act on adrenergic receptors, either presynaptically or postsynaptically on the effector organ
Adrenergic Drugs
Effect on adrenergic function
Agonist - stimulatory
Antagonist - inhibitory
Vasoconstriction
Increased peripheral resistane
Increased blood pressure
Mydriasis
Increased closure of bladder internal sphincter
A1 adrenoceptor
Inhibition of norepinephrine release
Inhibition of acetylcholine release
Inhibition of insulin release
A2 Adrenoceptor
Tachycardia
Increased lipolysis
Increased myocardial contractility
Increased renin release
B1 Adrenoceptor
Vasodilation
Decreased peripheral resistance
Bronchodilation
Increased muscle and liver glycogenesis
Increased glucagon release
Relaxed uterine smooth muscle
B2 adrenoceptor