Osteoarthritis

Question 1

OA:

Answer 1

progressive joint disease affecting hands, feet, hips, knees and spine; inflammation and breakdown of cartilage + bone

Question 2

OA features:

Answer 2

loss of articular cartilage, bone cysts/bone thickening, osteophyte formation, synovitis

Question 3

cartilage composition in OA:

Answer 3

fibrillation, fissures, delamination + bone exposure

Question 4

early OA:

Answer 4

chondrocyte death, upregulation of inflammatory responses, degradation of cartilage + fibrillation, erosion, microfractures

Question 5

later OA:

Answer 5

chondrocyte hypertrophy - calcified cartilage, cartilage degradation affects chondrocytes (increased inflammatory response), bone remodelling (thickness), formation of bone cysts and osteophytes, larger erosion of bone

Question 6

factors of developing OA:

Answer 6

structural abnormalities, malalignment, injury, feels, genetics, aging cartilage factors

Question 7

OA diagnosis:

Answer 7

persistent pain in 1 or more joints, older than 45, morning stiffness longer than 30 min