Osmolality Flashcards
Unit for osmolality
Osmoles per kilogram of water
What is a colligative property?
Property of solution influenced by the number of molecules and not the individual identity of the molecule
Normal values for serum osmolality
275-295 mmol/kg
What organ regulates the osmolality level inside the body ( be specific)
Hypothalamus
How does the body regulate the osmolality level
Thirst or secretion of anti diuretic hormone (ADH)
In healthy patients, what is the expected result of measured osmolality vs calculated osmolality?
Measured osmolality = Calculated osmolality
4 types of colligative property?
Boiling point, freezing point, vapor pressure and osmotic pressure
Effect of ingestion of water to osmolality
Osmolality will decrease
Method utilized to measure the dissolved particles in the solution
Osmometry
What is osmolal gap?
Represents the difference between the measured and calculated osmolality
Types of osmometry ( give 3)
- Serum and urine osmolality
- Freezing point depression osmometry
- Vapor pressure depression osmometry
Type of osmometry useful in assessing electrolyte disorder and acid base status
Serum and urine osmolality
The result of osmolality levels when ADH is produced inside the body
Increased levels of osmolality due to the water retention action of ADH
Type of osmometry wherein the evaporation of the water is decreased due to the presence of solute particles in the solution
Vapor pressure osmometry
Normal value for osmolal gap
Should be less than 15
Relationship of decrease in temperature and the number of particles in the solution present
Directly proportional
In vapor pressure osmometry, what is the relationship between the osmolality of a solution and the vapor pressure?
Inversely proportional ( pag mataas ang vapor pressure, low ang osmolality)
Reasons for osmolal gap (give 3 reasons)
- Excess production of Beta hydroxybutarate
- Ingestion of toxins (ethylene glycol)
- Ingestion of large amounts of alcohol
Unit for serum osmolality?
millimoles per kilogram ( mOsm/kg)
Major molecules measured by serum and urine osmolality?
Sodium, Chlorine , Urea and Glucose
Particles in a solution cause the freezing point of pure water to be decreased.
Freezing point depression osmometry
What is osmolality?
Number of dissolved particles in a solution
Formulas used to calculate osmolality (give 2)
1.86Na + glucose/18 + BUN/2.8 + 9 = mOsm/kg
2Na + glucose/20+ BUN/3.0 = mOsm/kg