OSCE Revision Flashcards
anterior cerebral artery blockage will lead to weakness of
lower limb contralaterally
vascular dementia presentation
step wise progression
onset can be sudden or gradual
executive function deficits prominent early
mood disturbances and disorders are common
neuro deficits and gait problems early
later stages = psychosis, delusions, hallucinations, paranoia
can be alongside alzheimers
AIDP
acute inflammatory demyelinating polyneuropathy
most common variant of GBS - 95% cases
Weakly positive birefringent, rhomboid shaped crystals
Calcium pyrophosphate = pseudogout
how to measure lying and standing BP
patient lay down for 5/10 minutes
take BP
then stand and take BP at 1 min and 3 min
DVLA and stroke /TIA
group 1 - dont need to report. dont drive for 1 month and can drive if no sustained neuro deficits after 1 month
group 2 = 1 year cant drive
risk factors for vascular dementia
main = HTN
smoking, diabetes, hyperlipidaemia, obesity, hypercholesterolaemia
retinal detachment presentation
new onset floaters, photopsia (bright flashes), sudden onset progressing visual field loss - a dark shadow that moves inwards
RAPD if macula or >1/2 retina detaches
Smith’s fracture
Volar displacement of radius head
treatment of parkinsons disease
1) levodopa + dopa decarboxylase inhibitor
2) dopamine agonist
3) MAO-B inhibitor
presentation of bacterial conjunctivitis
mucopurulent secretions, red eye, stinging, FB feeling, mild/moderate pain, glued eyes upon waking, papillae under eye lid
Z shaped thumb
Sign of RA-MCPJ flexion and IPJ extension
Negatively birefringent, needle shape crystals
Monosodium urate = gout
co beneldopa
levodopa and Benserazide
features of vascular parkinsonism
gradual or step wise deterioration small vessel disease symmetrical predominantly leg symptoms 50% respond to leva dopa
prophylactic treatment for migraine
if > 2 headaches a month
propranolol, topiromate, amitriptyline
2nd line - sodium valproate, botox
Ankle joint bones
Tibia, fibula and talus
Radial inclination
Normal wrist has 25 degrees radial inclination
presentation of parkinsons disease
resting tremor rigidity bradykinesia - reduced arm swing, progressive reduction in amplitude of repetitive movements fixed facial expression reduced blinking hypophonia (quiet voice) micrographia (little writing) gait disturbance hyposmia non motor symptoms - ANS: orthostatic hypotension, constipation, inconinence, sleep disorders, intense dreams, dysphagia, memory/ concentration problems.
prophylaxis of further aacg attacks
laser peripheral iridotomy
amiodarone
used for cardioversions in atrial fibrillation
donepezil
cholinesterase inhibitor for dementia
delirium
acute onset, fluctuating confusion due to an underlying treatable cause
investigations for encephalitis
LP - PCR for HSV, VZV and enterovirus
MRI and bloods
blockage of middle cerebral artery will lead to weakness/sensory loss of
contralateral face and arm
signs of radial nerve palsy
wrist drop (no wrist extensors) sensory loss of central posterior arm and thumb
Bouchards nodes
PIP joint swelling in OA
side effects of levodopa
dyskinesia with long term use
impulse control disorder
on/off fluctuations
reduced effect with time
nausea, vomiting, hypotension, poor appetite, psychological problems, sleep problems, hallucinations
how does viral conjunctivitis present
no/mild pain, watery discharge, diffuse red injections, mild itching, gritty feeling, lymphoid follicules under eyelid, pre-auricular lymphadenopathy
aetiology of delirium
Constipation Hydration Infection Metabolic disturbance Pain Sleeplessness
Prescriptions Hyperthermia or pyrexia Organ dysfunction - renal/hepatic Nutrition - vitamin deficiencies Environmental Drugs
others: hypoxia, surgery, hypoglycaemia, B12 deficiency, traumatic head injury, encephalitis
managing difficult delirium
use verbal/non verbal techniques to deescalate
if needed
short term haloperidol 0.5mg oral or 1mg IM
(not in parkinsons or LB dementia)
or Lorazepam
acute angle closure glaucoma presentation
severe, rapidly progressing pain, brick red eye, progressive headache on affected side, vomiting, rapidly progressing visual loss, corneal clouding, haloes, v high iop, mid dilated fixed pupil
Bamboo spine
Seen in ankylosing spondylitis , Due to ossification of the annulosus fibrosis and interspinous ligaments
hypoactive delirium
lethargy
slowness with everday tasks
inattention
excessive sleeping
5 common malignancies that spread to bone
Thyroid, lung, breast, renal, prostate
secondary prevention for TIA
treat AF treat carotid stenosis treat HTN optimise diabetes lifestyle changes treat vascular risk factors
Carpal bones
Bones of the wrist - Scaphoid, lunate, triquetral, pisiform, Trapezium, trapezoid, capitate, hamate
how often should diabetic patients be screened for DR?
at diagnosis and then annually
what are the 3 essential meds you cant miss in hospital
parkinsons meds
anti epileptics
insulin
strongst predictors of stroke prognosis
age and severity of stroke
AMT 4
age
dob
place
year
iridocorneal angle
the angle involved in glaucoma
latanoprost
prostaglandin analogue that lowers pressure in the eye by increasing drainage of aqueous humour
used in glaucoma
Aflibercept
Anti VEGF injection - used for wet AMD and oedema in DR
DVLA and epilepsy
1st unprovoked seizure = 6 months for group 1, 5 years for group 2
epileptic seizure = 12 months for group 1, 10 years for group 2
cant drive during period of AED withdrawal/changeover and for 6 months post
ropinirole
dopamine agonist for PD rx
Volar displacement
Displacement of the distal radius towards the palm of the hand #
4AT assessment
Alertness
AMT 4
Attention - months from december backwards
Acute onset and fluctuating
> 4 = delirium
crescendo TIA
2+ in 1 week
classic gait abnormalities in parkinsons
small shuffling steps with stooped posture.
unsteadiness on turning
difficulty stopping - festination
tendency to fall
‘freezing’ in doorways/ patterned carpets
uveitis presentation
associated with systemic inflammatory conditions- especially ankylosing spondylitis.
dull orbital pain, red eye, reduced vision, synechia, flare, tearing, floaters, photophobia
apraclonidine
alpha 2 adrenergic agonist - used in glaucoma to lower IOP by stopping aqueous humour production
best AED for pregnancy
lamotrigine with folic acid 5 mg
posterior column syndrome
loss of proprioception/vibration/fine touch below the lesion. sensory ataxia and positive rhombergs
Methotrexate given with
Folic acid
most common vasculitis in adults , affecting branches of the external carotid
giant cell arteritis
pathway of spinothalamic tracts
decussates soon after entering spinal cord and ascends in contralateral side
gonioscopy
measures the angle between the cornea and iris
loteprednol
topical steroids eye drops
osteoporosis treatment
colecalciferol and calcium supplement
alendronic acid - bisphosphanate
co careldopa
levodopa and carbidopa
Pilon #
Severe # to ankle – usually from jumping from a large height
signs of common peroneal nerve palsy
Hx of kneeling
weakness of foot dorsiflexion (causing foot drop) and eversion
anomia
unable to identify objects
how to prevent stroke in patients with AF
warfarin (INR aim 2-3) or apixaban/dabigatran
PC of MS
optic neuritis, weakness or loss of sensation, ataxia, facial weakness, nystagmus, diplopia, vertigo, deafness, transverse myelitis, cognitive and psychological symptoms
treatment of optic neuritis
Iv methylprednisolone with GI protection
Leflunomide
DMARD
treatment for encephalitis
Benzylpencillin for bacterial meningitis
IV acyclovir for HSV encephalitis
pseudodementia
due to a functional cause
depression
psychogenic
or hysterical
seizure
abnormal excessive neuronal activity in the brain leading to impairment of normal cognitive function
frontotemporal dementia treatment
antidepressants
antipsychotics
differnetiate between essential tremor and parkinsons disease
DaTScan
imagies the dopamin reuptake in the basal ganglia.
normal in essential tremor and not in PD
Ranibizumab
anti VEGF - used for wet AMD and oedema in DR
pathophysiology of diabetic retinopathy
hyerglycaemia- ishaemia - neovasculisation - leaky vessels - haemorrhage and oedema
management for falls
treat underlying cause
optimise sight
optimise mobility - balance and strength training with physio
optimise enviroment - OT
optimise foot wear - podiatry
medication review and stop drugs increasing risk
check osteoporosis and treat
side effects of dopamine agonists
impulsive behaviours +++
sleepines, fainting, nausea, constipation, confusion, hypotension, headaches, psychological problems
the different patterns of MS
RRMS 80% cases - becomes SPMS IN 50% of these
PPMS 15% cases
stages of alzheimers dementia
1) mild cognitive impairment - short term memory loss (Temporal lobe)
2) mild AD - reading problems and poor object recognition (parietal lobe)
3) moderate AD - poor judgement, impulsivity, short attention (frontal lobe)
4) severe AD - vision problems (occipital lobe)
HAS BLED
- risk of bleeding on anticoag for AF
HTN
Abnormal LFTs/Renal function
Stroke
Bleeding
Labile INR
Elderly >65
Drugs/alcohol
optical coherence tomography
mandatory test for AMD diagnosis
image of cross section of the retina
todds paresis
transient paralysis following seizure
lasts 48hrs
chloramphenicol
topical eye drop antibiotic to treat bacterial conjunctivitis
epinastine
topical eye drop antihistamine for conjunctivitis
syncope
global cerebral hypoperfusion
Schatzker classification
Classifies tibial plateau fractures
secondary dementia
reversible dementias due to a medical condition
Volar tilt
Normal wrist has 10 degrees volar tilt
pathophysiology of lewy body dementia
pathology of LBD mimics idopathic parkinsons
lewy bodys are composed of protein alpha synuclein
Mason classification
Classifies radial head fracturs 1=undisplaced 2 = displaced 3=comminuted
Boutonnieres deformity
Sign of RA-Hyperextended DIPJ and hyperflexed PIPJ
side effects of MAO B inhibitors
headache, aching joints, indigestion, flu-like symptoms, depression
can worsen side effects of ldopa - sickness and dyskinesia
entacapone
a cOMT inhibitor
taken with ldopa will prevent its break down and have a longer effect
hypopyon
pus in anterior chamber
triad of normal pressure hydrocephalus
dementia
gait disorder
bladder instability
risk factors for ischaemic stroke
hypertension carotid stenosis AF contraceptive pill clotting disorder diabetes smoking ischaemic heart disease peripheral vascular disease polycythaemia
scleritis
painful, associated with systemic inflammatory conditions (especially RA), pain with eye movement, visual loss
triad of encephalitis
fever, headache and altered mental status
prognosis of delirium
2/3 recover
1/3 wont recover completely- die or need care home
treatment for viral conjunctivitis
1) topical antihistamine +/- artificial tears
2) topical steroids
3) topical ganciclovir if confirmed adenovirus
Foot bones
Talus, Calcaneum, cuboid, navicular, 3 x cuneiforms
GBS prognosis
normal = max disability at 4 weeks
20% will have persistent neuro problems (of which 50% will be severe)
3-7% mortality
20% can’t walk unaided at 6 months
tia management
aspirin 300mg
risk asses for stroke
secondary prevention
Hallux valgus
Bunion , The big toe turns into valgus (laterally) towards the other toes
Susceptible nerve in humeral neck fracture
Axillary nerve
Susceptible nerve in elbow fracture
Ulnar nerve
dorsal columns carry
sensation of fine touch, proprioception and vibration
differentials of headache
tension headache cluster migraine drug induced meningitis space occupying lesion GCA sinusitis acute glaucoma trigeminal neuralgia subarachnoid haemorrhage
Odontoid peg
Peg on C2 vertebrae
presentation of giant cell arteritis
temporal head ache, scalp tenderness, jaw claudication, upper limb pain on use, polymyalgia rheumatica, partial or complete visual loss, systemic symptoms
causes of orthostatic hypotension
hypovolaemia - haemorrhage /vomiting /diarrhoea /dehydration
iatrogenic - betablockers, diuretics, vasodilators, alcohol, antidepressants, phenothiazines
autonomic failure - diabetic neuropathy, Parkinson’s disease, spinal cord injury
vascular dementia pathophysiology
caused by multiple small cerebrovascular infarcts, small vessel disease and a single cerebrovascular accident
alzheimers dementia pathophysiology
amyloid plaques - clumps of amyloid and degenerated neurons neurofibrillary tangles (mostly made of tau proteins)
hyperactive delirium
agitation delusions hallucinations aggression wandering
proptosis
abnormal protrusion of eye/s
physiological tremor features
increased SNS stimulation e.g. due to stress
action tremor
Multiple sclerosis characteristics
1) formation of lesions/plaques - in white matter (optic nerve/brain stem/ basal ganglia/ spinal cord/ corpus callosum
2) destruction of myelin sheath - demyelination
3) inflammation - cell mediated ( a break in the BBB allows them entry into the CNS)
presentation of early macular degeneration
central vision loss (scotoma or poor acuity), reduced contrast sensitivity, light glare, metamorphopsia
myasthenia gravis
a neuromuscular autoimmune condition - caused by antibodies against nicotinic acetylcholine receptor
forehead sparing is seen in
UMN palsy
Ulnar deviation
At the MCP joints-Might develop to subluxation
presentation of allergic conjunctivitis
severe itch, tearing, diffuse redness, papillae present
otorrhoea
discharge from ear
POCs criteria
1 of 3 present
- isolated homonymous hemianopia
- LoC
- cerebellar or brain stem syndrome
pathophysiology of CPOAG
reduced aqueous humour flow through the trabecular meshwork - raised IOP - hydrostatic pressure on the optic nerve and compromise of vasculature causing ischaemia leads to retinal ganglion apoptosis
galantamine
cholinesterase inhibitor for dementia
Pre-patellar bursitis
Housemaids knee – able to flex and relatively pain free
optic neuritis presentation
peri orbital/retro occular pain - worse on movement, loss of visual acuity with scotoma, RAPD, loss of colour vision, optic disc swelling, perception of seeing light due to eye movement or pressure on eye, swelling of optic disc on fundoscopy
presentation of CRAO
sudden painless loss of vision, RAPD
pale oedematous retina and cherry red spot fovea (underlying choroid)
differentials for space occupying lesion
infection - abscess, empyema, granuloma (TB)
vascular - stroke/haemorrhage
neoplasm - primary or secondary (glioblastoma)
hydrocephalus
corticospinal tracts
lateral tract decussates in the medulla
anterior decussates in the cervical/thoracic spine
cholesteatoma presentation
painless otorrhea - frequent or unremitting
progressive conductive hearing loss
erosion into local structures may lead to vertigo, headaches and facial nerve palsy
recurrent otitis media
Lewy body dementia core features
- visual hallucinations
- REM sleep disturbance
- fluctuating cognition, attention and arousal
with 1+ cardinal features of parkinsonism
treatment of AACG
emergency
1. brinzolamide (carbonic anhydrase) with timolol (beta blocker) and brimonidine (alpha 2 antagonist)
most common cause of bacterial conjunctivitis
staphylococus
streptococcus
4 main factors that lead to development of pressure sore
interface material
shear
friction
moisture
aetiology of falls
DAME
Drug induced
Age related - vision/instability
Medical - acute illness/syncope/seizure/stroke
Environmental
herpes keratitis sign
dendritic/geographic ulcer
treatment of endophthalmitis
intravitreal antibiotic injection if bacterial
treatment for AF
rate control - beta blocker or rate controlling CCB
2nd line = combo
rhythm control if rate control not working: amiodarone or electrical conversion
aphasia
inability to comprehend or produce languange/communicate
Hydroxychloroquine
DMARD
which level in the spine separates lower and upper limb innervation
T6
what is 3:1 atrial flutter
the beat is only conducted to the ventricles every 3 atria beats
HR = 100bpm
keratitis presentation
odeama and opacification of the cornea, corneal ulcer, redness, pain, discharge, lid oedema, reduced vision, photophobia, high IOP
Management of hip OA
Total hip replacement
drugs which induce parkinsonism
dopamine receptor antagonists
metaclopremide
haloperidol
cyclizine
prochlorperazine
natalizumab
anti lymphocyte moniclonal antibody
used in very active MS