OSA Flashcards

1
Q

Is COPD reversible?

A

Partially, but not fully reversible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What systemic manifestations is severe COPD associated with?

A

Cachexia, generalized weakness, osteoporosis, depression, anxiety, coronary artery disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

In which disease is there permanent enlargement of airspaces?

A

Emphysema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Role of alpha-1-antitrypsin

A

Inhibits elastase, keeping the balance of breakdown of elastic fibers in check

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name 5 risk factors for COPD

A

Smoking, exposure to occupational dusts, family history of COPD, alpha-1-antitrypsin deficiency, and older than 45 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How is DLCO affected in asthma?

A

Increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How are DLCO, RV, and TLC affected in COPD, particularly emphysema?

A

Decreased DLCO because of decrease in capillary bed due to lung parenchyma loss in COPD, and increased RV and TLC due to air trapping causing hyperinflated lung indicative of air trapping, in emphysema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Top causes of chronic cough (more than or equal to 8 weeks)

A

UACS (upper airway cough syndrome) or post-nasal drip (sinusitis leads to excessive mucus which accumulates in back of throat), asthma, GERD, and chronic bronchitis. Also, role of ace inhibitors and bordatella pertussis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Expiratory time in COPD

A

Forced expiration time greater than 6 seconds, normal is 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

COPD classifications according to GOLD criteria

A

Stage 1 mild, 2-moderate, 3-severe, 4-very severe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Normal FEV1/FVC ratio

A

greater than or equal to 80%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

FVC and FEV1 normals

A

should be greater than or equal to 80%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

5 A’s and R’s in behavior interventions of COPD smoking management

A

Ask, advise, assess, assist, arrange. Relevance, risks, rewards, roadblocks, repeat.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Bronchodilators used in COPD management

A

Beta 2 agonists and anticholinergics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Beta 2 agonist short acting and long acting

A

short acting- albuterol, levalbuterol, pirbuterol. long acting- salmeterol, formoterol, indacaterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

anticholinergics as bronchodilators- name

A

Short acting- ipratropium. long acting- tiotropium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Inhaled corticosteroids for management of COPD

A

Fluticasone, budesonide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

COPD medications-name

A

Bronchodilators, corticosteroids, combinations, methylxanthines, phosphodiesterase-4 inhibitors, mucolytic agents (little management), and antibiotics for acute exacerbations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is methylxanthine and name a couple

A

Phosphodiesterase inhibitors- theophylline and aminophylline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Side effect of inhaled corticosteroids?

A

Thrush- tell patients to swish and spit 3 x

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are different ways in which bronchodilators can be administered?

A

Metered dose inhalers, dry powder inhalers, and nebulizers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How do phosphodiesterase-4 inhibitors work?

A

Increase intracellular cAMP and decrease inflammation. Promote airway smooth muscle relaxation. Decrease exacerbations if frequent of chronic bronchitis. Ex: Roflumilast PO.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is pirbuterol?

A

Short acting Beta 2 agonist used for bronchodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is theophylline?

A

Methylxanthine, phosphodiesterase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What is Roflumilast?
Phosphodiesterase-4 inhibitor
26
What is budesonide
Inhaled corticosteroid to suppress immune system
27
What is tiotropium?
Long acting anticholinergic
28
What is indacaterol?
Long acting beta 2 agonist for bronchodilation
29
What is ipratropium?
Short acting anticholinergic
30
Mucolytic agents
Guaifenesin, N-acetylcysteine
31
Meds for acute exacerbations in COPD
Abx- macrolides, sulfa drugs, tetracyclines, penicillins, cephalosporins, and/or FQs. Chronic azithromycin.
32
What would help in reducing frequency of acute exacerbations in COPD?
Azithryomycin
33
Predominant organisms causing acute exacerbations in COPD?
H. influenzae, strep pnuemo, moraxella catarrhalis, although usually viral infection precedes exacerbations
34
Advanced COPD complications
Pulmonary HTN, cor pulmonale, chronic respiratory failure
35
Cardinal features of asthma
Reversible airway obstruction, airway inflammation, and airway hyperresponsiveness to a multiplicity of stimuli
36
In which disease state would you see a lot of eosinophils, mast cells activated, subepithelial fibrosis, and mucous gland and goblet cell hyperplasia and what would this lead to?
Asthma- lots of mucus, leads to mucus plugging and further narrowing/blockage of airways
37
When is the onset of asthma most common?
in childhood. If in adulthood, often occupation related.
38
What is the predominant symptom in asthma patients?
Nonproductive cough
39
Associated conditions with asthma
Nasal polyps (have allergic etiology), rhinitis, and sinusitis
40
8 year old girl presents describes periods of dyspnea, chest tightness, and coughing. Upon auscultation, you hear wheezes, decreased breath sounds. Hyperinflation of lungs and use of accessory muscles to breathe. She also has a history of getting nasal polyps frequently. Diagnosis?
Asthma
41
How would you diagnose asthma?
Bronchoprovocation testing with methacholine if normal spirometry and you are suspicious. Allergy skin test or radioallergosorbent test, ABG
42
If you see a severe asthma patient with normal PaCO2 levels, what do you suspect?
Respiratory failure
43
What is a radioallergosorbent test?
Tests serum IgE levels
44
What are the classifications in asthma based on?
frequency of daytime/nighttime symptoms, need for rescue inhaler, limitation in activity, and lung function. Severity is based on worse feature present
45
Which obstructive diseases are very prone for recurrent bacterial infections?
CF and chronic bronchitis
46
What is the most common genetic cause of bronchiectasis?
CF
47
Etiology of CF
Genetic defect of chromosome 7 which produces a defective CFTR gene
48
What cells are effected by CF
Of epithelial origin- lungs, sinuses, GI system, sweat glands, hepatobiliary system, reproductive tract
49
In which age of CF would you find clinical features of tachypnea, feeding problems, retractions, and recurrent sinopulmonary infections?
Infant
50
In which age of CF would you find clinical symptoms of rectal prolapse, jaundice, and meconium ileus?
Neonate
51
In which age of CF would you find clinical features of diffuse rhonchi/rales, clubbing, cough, and hemoptysis?
Child or adolescent
52
What is the most common cause of clubbing in children?
CF
53
16 year old presents with cough, recurrent hemoptysis. You note diffuse rhonch and rales, clubbing of the extremities, and steatorrhea. Hyperresonance to percussion. Mother complains that child is unable to gain weight, no matter how much he eats. Delayed sexual maturity. Diagnosis?
CF
54
Why would you get a sputum culture in CF?
To monitor if bronchiectasis has developed within the patient- most common organisms affecting are Staph and H. influenzae
55
Diagnosis of CF
Sweat chloride test, genetic test to look for 2 CF alleles, family history with first degree relative of CF, nasal potential difference, cXR, PFT, sputum culture, fecal fat analysis, semen analysis,
56
Why do a semen and fecal fat analysis in CF?
Because of pancreatic insufficiency, the small intestine is not digesting the fats. This leads to steatorrhea in which theres excessive discharge of fat in the feces. Semen analysis will show decreased sperm.
57
What would CXR tell you in CF?
Do this if suspicious of bronchiectasis. May see hyperinflation and ring shadows and cysts.
58
What is nasal potential difference testing?
Measures how well sodium and chloride flow across the mucous membranes in the nose
59
False positives for sweat chloride test in CF
AAddisons, hypothyroidism, nephrogenic diabetes insipidus
60
When is the sweat chloride test positive?
when chloride is greater than 60mmol/L in children
61
What is death usually due to in CF?
Respiratory failure
62
Median survival age of CF
36 years
63
Lung transplantation for CF should not occur if chronic infection with this organism
Burkholderia cenocepacia
64
How does Ivacaftor work
Is a CFTR modulator in CF patients with G551D mutation. It increases the amount of time the CFTR channel remains open.
65
4 components of therapy for CF
Mobilization of secretions, nutritional interventions, ATB therapy of chronic bronchiectasis, and control of airway inflammation
66
Patient presents with chronic cough, purulent, foul smelling sputum, fever, weakness, weight loss. Rale, rhonchi, and wheezes heard on auscultation. CXR shows bronchial wall thickening and airway dilation. What is the diagnosis?
Bronchiectasis- suspect diagnosis if chronic bacterial infection and the production of large quantities of foul-smelling sputum
67
Are recurrent infections with bronchiectasis common?
Yes
68
Diagnosis for bronchiectasis
Definitive test by HRCT- dilated airways that are thickened due to mucopurulent plugs (tree in bud pattern). CXR shows bronchial wall thickening, ring shadows with cysts. CBC, sputum culture and smear to check if bacterial cause, PFT, bronchoscopy
69
What condition can bronchiectasis lead to?
Pulmonary HTN
70
Who does bronchiolitis most commonly affect?
Infants and kids
71
Most common cause of bronchiolitis?
RSV- especially in witner months, and rhinovirus
72
3 main types of bronchiolitis in adults
Proliferative, constrictive, or follicular
73
Clinical features of bronchiolitis in children
Tachypnea, retractions, wheezing on expiration, grunting, nasal flaring cyanosis
74
Clinical features of bronchiolits in adults
Sneaky onset of cough and dyspnea
75
How is bronchiolitis diagnosed?
Clinically