OSA Flashcards
OSA: General
- Increased resistance to airflow; No breathing when trying to breathe
- Results in hypopnea or Apnea
– Degree and duration->Hypoxia, anoxia, hypercarbia - Arouses CNS-> Lighter Sleep Stage (nREM 1 or 2)
- causes: partial awake, Relieve obstruction, resume breathing
- Fragmented Sleep: Depending on arousal frequency
Apnea
- Complete Obstruction
- cesstion or near-complete cessation (>70%) of oronasal airflow
- at least 10 seconds
Hypopnea
- Partial Obstruction
- 30% decrease oronasal airflow= 4% decrease Oxyhemoglobin saturation
- 50% decrease oronasal airflow= 3% decrease oxyhemoglobin saturation
Types of Apnea Pattern
- Obstructed Sleep Apnea
- Central Sleep Apnea
- Mixed Sleep Apnea
Obstructed Sleep Apnea
- Absence of airflow w/persistent ventilatory efforts
Central Sleep Apnea
- Absence of airflow w/no ventilatory efforts
Mixed Sleep Apnea
- Both Central and Obstructive events
- Central then Obstructive
Etiology of OSA
- Structural risk factors
- Non-structural risk factors
OSA: Structural Risk Factors
Nasal Cavity/Nasopharynx
1. Septal Deviation
2. Turbinate Hypertrophy
3. Nasal Polyps
4. Adenoid Hypertrophy
Oral Cavity/ Oropharynx
1. Soft palate and Uvula elongation
2. Tonsillar Hypertrophy
3. Macroglossia
4. Retrognathia
5. Rugae of posterior pharyngeal wall
Hypopharynx/Larynx
1. Omega Shaped Epiglottis
2. Laryngeal-tracheal stenosis
OSA: Non-structural Risk Factors
- Obesity
- Age
- Sex
- Post-menopause
- Family Hx
- Genetics
- Alcohol
- Smoking
OSA: Obesity
- Major risk factor
- Increased adipocity around pharynx and body
- Potential Candidates: Sleep in supine position w/:
increased neck circumferance (collar size >16-17) or
High BMI(>25)
OSA: Age
- Increased fat in parapharyngeal area
- Structural change around pharynx
- Soft palate lengthens
OSA: Sex
- Men have increased fat around pharyngeal airway
OSA: Post-menopause
- Post menopause=higher prevalence
- Post-menopause w/hormone replacement therapy= same as Pre-menopause
- Pre-menopause=Protected even with other risk factors
OSA: Family Hx & Genetics
*Familial suceptibilty increases directly with number of affected relatives
* 1st degree relatives: 1.5-2x
* APOE= younger w/OSA
* Carniofacial Disorders: Pierre-Robine Syndrome
have micrognathia, glossoptossis, cleft palate, tonge prolapse backwards