OS 202 C Samplex 2018 Flashcards
Which of the following bind to intracellular receptors?
a. T3 and TSH
b. ACTH and cortisol
c. testosterone and estrogen
d. insulin and glucagon
C
Peptides and proteins
a. are produced initially as inactive prehormone
b. require binding with plasma protein
c. bind to nuclear receptors
d. derived from cholesterol
A
Mediated by increased cAMP
a. increased aldosterone by angiotensin
b. increased ACTH by CRH
c. vasoconstriction by ADH
d. AOTA
NO ANSWER IN SAMPLEX
Which does not contribute to POMC processing in the human corticotrope
a. ACTH
b. B-endorphin
c. Lipoprotein
d. CLIP
NO ANSWER IN SAMPLEX
A 30-yr old woman had necrosis of the pituitary gland after delivery. She had deficient LH, FSH, TSH and PRL. What hormone therapy should she have
a. PRL
b. aldosterone
c. T4
d. epinephrine
e. AOTA
NO ANSWER IN SAMPLEX
Transection of pituitary stalk
a. Decreased cortisol, decreased ACTH
b. Decreased cortisol, increased ACTH
c. Increased cortisol, decreased ACTH
d. Increased cortisol, increased ACTH
A
Tuberculous infiltration of adrenal cortex
a. Decreased cortisol, decreased ACTH
b. Decreased cortisol, increased ACTH
c. Increased cortisol, decreased ACTH
d. Increased cortisol, increased ACTH
D
Induces an increase during prolonged intake of cortisol
a. sensitivity of peripheral tissues to insulin
b. blood glucose concentration
c. blood DHEA
d. AOTA
NO ANSWER IN SAMPLEX
Biological effects of cortisol
a. decreased rate of utilization in muscle and adipose tissue
b. decreased protein synthesis in liver
c. facilitates mobilization of fatty acids
d. increased liver gluconeogenesis
e. NOTA
NO ANSWER IN SAMPLEX
ACTH secreting tumor
a. Decreased cortisol, decreased ACTH
b. Decreased cortisol, increased ACTH
c. Increased cortisol, decreased ACTH
d. Increased cortisol, increased ACTH
D
Which of the following is true about insulin?
a. The active hormone is composed of 4 peptides
b. The secretory granules contain insulin and c-peptide in 2:1 ratio
c. insulin is released into the duct of Wirsung to reach the liver
d. The order of synthesis of the polypeptide chain is n-terminal signal peptide- b-chain- c-peptide- insulin
D
Insulin affects the metabolism of which substances?
a. carbohydrates
b. carbohydrates and fats
c. carbohydrates and proteins
d. carbohydrates, fats and proteins
D
With inactivating mutation to GLUT-2 transporter
a. patient loses consciousness and seizure
b. pancreas do not produce insulin when glucose increases after meals
c. glucose is not transported to muscles and adipose
d. fructose is not transported to sperm
B
What happens after pancreatectomy?
a. hypoglycemia
b. decreased FFA
c. decreased acetoacetate
d. metabolic alkalosis
D
What is true about PTH?
a. synthesized by parafollicular cells in the thyroid
b. single chain peptide
c. all 84 amino acid are required to function
d. it has an intracellular receptor in the cytoplasm
NO ANSWER IN SAMPLEX
Which of the ff is not a direct effect of PTH?
a. increased bone resorption
b. increased intestinal absorption of calcium
c. increased renal tubular reabsorption of calcium
d. decreased renal tubular absorption of phosphate
B
Your grandmother wants to prevent osteoporosis by taking calcium tablets. However, she takes 20 pcs of 500 mg tablets daily, way more than recommended. What are the physiologic adaptations that occur as a response?
a. PTH gland secrete more PTH
b. 1-α- hydroxylase enzyme activates Vit D
c. Renal tubular absorption of Ca is inhibited
d. Increased osteoclastic activity
C
Effects of hypothyroidism except
a. low BP
b. constipation
c. weight gain
d. coma
NO ANSWER IN SAMPLEX
An increase in TRH would lead to
a. decrease in adipocytes
b. cold exposure
c. increased leptin
d. iodine deficiency
NO ANSWER IN SAMPLEX
Basophilic cells of adenohypophysis
a. lactotroph
b. somatotroph
c. thyrotroph
d. corticotroph
A
Salt Loading
a. Decreased renin, decreased aldosterone
b. Increased renin, decreased aldosterone
c. Decreased renin, increased aldosterone
d. Increased renin, increased aldosterone
A
Which is true about insulin secretion?
a. Decreased blood glucose, decreased insulin secretion
b. Decreased blood glucose, increased insulin secretion
c. Increased blood glucose, decreased insulin secretion
d. Increased blood glucose, increased insulin secretion
D
