Orthomyxoviridae Flashcards
1
Q
Baltimore classification of Orthomyxoviridae
A
class V ss(-) RNA
2
Q
influenza morphology
A
Quasi-spherical or filamentous, enveloped particles. Envelope derived from host cell plasma membrane by budding. contains HA and NA on matrix protein. RNP has helical nucleocapsid.
3
Q
RNA polymerase complex
A
PA, PB1/2. PA is a protease. PB2 is responsible for cap-snatching, PB1 makes the cap a primer and elongates.
4
Q
role of HA and NA
A
HA helps with the endonuclease entry of the virus. NA destroys cell receptors during cell escape to prevent reinfection.
5
Q
antigenic shift
A
hybrdi virus emerges when cell infected with multiple influenza viruses. transfer of influenza to a different
6
Q
antigenic drift
A
point mutations accumulated during virus replication.
