Origins and Effects of Circulating Exotoxins and Endotoxin Flashcards
Toxic in high doses
endotoxin
Toxic in minute amounts
exotoxins
Causes systemic symptoms (fever and inflammation)
endotoxin
Specific to a cell type (blood, liver, nerve); induces TNF production resulting in fever
exotoxins
stable at 60 degree C
endotoxin
unstable at 60 degree C
exotoxins
Comes from lipopolysaccharide of gram negative cell wall
endotoxins
comes from small proteins
exotoxins
cannot be converted to toxoid
endotoxin
can be converted to toxoid
exotoxins
Does not stimulate antitoxins
endotoxins
stimulates antitoxins
exotoxins
causes fever
endotoxins
usually does not cause fever
exotoxins
released by cells via shedding or during lysis
endotoxins
secreted from live cells
exotoxins
can come from gram-positive and gram-negative sources
exotoxins
comes from only gram negative bacteria
Endotoxins