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Pharma Spring 2021 > ORGANOTROPIC AGENTS - Drugs used in disorders of coagulation > Flashcards

ORGANOTROPIC AGENTS - Drugs used in disorders of coagulation Flashcards

1
Q

Physiologic reactions are involved in the control of bleeding

A
  • Platelet adhesion reaction
  • Platelet release reaction
  • Triggering of the coagulation process
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2
Q

Physiologic reactions that are not involved in the control of bleeding

A

Activation of the antifibrinolytic system

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3
Q

Which substances is synthesized within vessel walls and inhibits thrombogenesis?

A

Prostacyclin (PGI2)

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4
Q

The following groups of drugs are for thrombosis treatment

A
  • Anticoagulant drugs
  • Fibrinolitic drugs
  • Antiplatelet drugs
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5
Q

The following group of drugs are not for thrombosis treatment

A

Antifibrinolitic drugs

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6
Q

Drug belonging to anticoagulants of direct action

A

Heparin

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7
Q

Which drugs has low-molecular weight?

A

Enoxaparin

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8
Q

Indicate the drug belonging to antagonists of heparin

A

Protamine sulfate

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9
Q

Drug used as an oral anticoagulant

A

Dicumarol

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10
Q

Drugs are indirect acting anticoagulants

A
  • Dicumarol
  • Warfarin
  • Phenindione
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11
Q

Drugs that are not indirect acting anticoagulants

A

Dalteparin

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12
Q

Which drugs belongs to coumarin derivatives?

A

Warfarin

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13
Q

True or False. Heparin is effective when administred orally.

A

FALSE

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14
Q

Drugs that are antiplatelet agents

A
  • Aspirin
  • Ticlopidine
  • Clopidogrel
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15
Q

Drugs that are not antiplatelet agents

A

Urokinase

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16
Q

True or False. The use of heparin is recommended for treatment of deep venous thrombosis.

A

TRUE

17
Q

Mechanism of aspirin action is

A

Inhibits COX and thus thromboxane synthesis

18
Q

Which doses of Aspirin may be more effective in inhibiting Tromboxane A2? (Low or High)

A

LOW

19
Q

Which drugs is an inhibitor of platelet glycoprotein IIb/IIIa receptors?

A

Abciximab

20
Q

True or False. Ticlopidine is an inhibitor of ADP-induced platelet aggregation.

A

TRUE

21
Q

Which drugs is fiibrinolytic?

A

Streptokinase

22
Q

True or False. Mechanism of urokinase action is an inhibition of Thromboxane A2.

A

FALSE

23
Q

Fibrinolytic drugs are used for

A
  • Central deep venous thrombosis
  • Multiple pulmonary emboli
  • Acute myocardial infarction
24
Q

Fibrinolytic drugs are NOT used for

A

Heart failure

25
Q

Indicate the drug belonging to fibrinoliytic inhibitors

A

Aminocapronic acid

26
Q

Aminocapronic acid is a drug of choice for treatment of

A

Bleeding from fibrinolytic therapy

27
Q

True or False. Tranexamic acid is an analog of aminocapronic acid.

A

TRUE

Pharma Spring 2021 (3 decks)

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