ORGANIC MEDICINE

Question 1

the ratio of the solubility of the compound in an organic solvent to the solubility of the same compound in aqueous environment

Answer 1

Partition coefficient

Question 2

I. Unionized means increase lipid solubility, better absorption, increase kidney reabsorption, decrease excretion.

II. Ionized means decrease lipid solubility, not absorbed, decrease kidney reabsorption, increase excretion

A. Both statements are correct
B. Only I statements are correct
C. Only II statements are correct
D. Both statements are incorrect

Answer 2

A

Question 3

are inactive derivatives of active drug molecules that are converted to parent drug molecules in the body, typically by enzymatic process in the body

Answer 3

Prodrugs

Question 4

are chemical groups with similar physicochemical properties which give broadly similar biological properties to a compound and enhances it without significantly changing the chemical structure.

Answer 4

Bioisosteres

Question 5

also known as biotransformation

Answer 5

Metabolism

Question 6

colloquially known as ‘the morning after pill’

Answer 6

Levonorgestrel

Question 7

an enzyme responsible for glucuronidation

Answer 7

UDP-glucuronosyltransferase enzyme

Question 8

substances produced my microorganisms which has the capacity to inhibit growth or cause destruction of other microorganisms

Answer 8

ANTIBIOTICS

Question 9

the B-adrenergic bronchodilator, Salbutamol, undergo in this type of reaction under Phase II biotransformation

Answer 9

Sulfate conjugation

Question 10

toxic metabolite of paracetamol

Answer 10

N-acetyl-p-benzoquinone imine (NAPQI)

Question 11

protein synthesis inhibitors at 30 ribosomal subunit

Answer 11

Aminoglycosides & Tetracyclines (AT 30)

Question 12

protein synthesis inhibitors at 50 ribosomal subunit

Answer 12

Macrolides, Chloramphenicol, Clindamycin

MCC 50

Question 13

All aminoglycosides must be given parenterally because it has no oral absorption except for this drug which is given topically and oral only.

A. Tobramycin
B. Streptomycin
C. Neomycin
D. Gentamicin

Answer 13

C. Neomycin

Aminoglycosides are polar due to amino group —> no oral absorption EXCEPT Neomycin

Question 14

Most toxic aminoglycoside

Answer 14

Tobramycin

Question 15

The ff. are Spectrum for Tetracyclines EXCEPT:

I. Gram Positive
II. Gram Negative
III. Atypical bacteria
IV. Anaerobic bacteria
V. Pseudomonas

A. III ONLY
B. V ONLY
C. I-III
D. AOTA
E. III &IV

Answer 15

B

Question 16

The ff. are Spectrum for Aminoglycosides EXCEPT:

I. Gram Positive
II. Gram Negative
III. Atypical bacteria
IV. Anaerobic bacteria
V. Pseudomonas

A. III ONLY
B. V ONLY
C. I-III
D. AOTA
E. III &IV

Answer 16

E

Question 17

Pregnancy category for Tetracyclines

Answer 17

Category D

Question 18

Group of antibiotics that is used as substituent for patients allergic to penicillins

Answer 18

Macrolides (Erythromycin, Clarithromycin & Azithromycin)

Question 19

Drug of Choice for Rickettsia

Answer 19

Tetracycline

Question 20

the only macrolides that exhibit concentration-dependent killing

Answer 20

Azithromycin exhibit concentration-dependent killing

Erythromycin & Clarithromycin exhibit time-dependent killing