Organic Chemistry 5.0 - Pharmaceutical Chemistry Flashcards
What are drugs?
substances which alter the biochemical processes in the body
Drugs that have biochemical effects are used in ___.
medicines
What do medicines usually contain?
a drug, plus other ingredients such as filler to add bulk or sweeteners to improve taste
Drugs generally work by binding to specific ___ molecules, such as ___ ___, or specific ___ within a cell.
protein, surface receptor, enzymes
Which two things can drugs act on?
receptors
enzymes
Drugs which act on receptors can be classified as ___ or ___.
antagonists or agonists
What is an antagonist?
What is an agonist?
a substance which binds to a receptor and so blocks the natural response from occurring.
a substance which binds to a receptor and mimics a natural molecule, by producing a similar response (to the natural compound)
Many drugs are enzyme ___, which bind to the ___ ___ of the enzyme, preventing…
inhibitors, active site, the reaction which is usually catalysed there
The shape and size of a drug allows it to interact with… or…
an enzyme’s active site, or a receptor’s binding site
What are the types of interaction that occur between a drug and an enzyme’s active site/receptor’s binding site?
Van Der Waal’s forces and/or ionic bonds
This structural fragment of a drug molecule that allows it to interact with… or… consists of different ___ ___ correctly oriented with respect to each other.
enzyme active sites, receptor binding sites, functional groups
What is a structural fragment in a drug molecule?
a bunch of different functional groups correctly oriented with respect to each other.
Called pharmacophore- not in spec, dont use
By comparing the structures of drugs that have ___ effects on the body, the ___ fragment that is involved in the drug’s ___ can be identified.
similar, structural, function
