organ transplantation (general)

Question 0

what do immunosuppressant drugs do to prevent rejection?

Answer 0

block lymphocyte subsets responsible for immune response against new organ’s surface antigens

Question 1

what must match in order for a transplantation to take place?

Answer 1

1. HLA (human lymphocytic antigen) aka MHC (major histocompatibility complex–types A,B &O)

Question 2

how is immune response modulated?

Answer 2

1. macrophages present antigens to T-cells
2. B-cells use IL-1
   3.
   4.
   5.

Question 3

what are the side effects of these drugs:

1. cyclosporine
2. azathioprine
3. prednisone
4. antilymphocyte globin
5. OKT3

Answer 3

what are the side effects of these drugs:

1. cyclosporine-hypertension, elevated bun, enhanced renal sensitivity to insults
2. azathioprine*- severe leukopenia, anemia, thrombocytopenia
3. prednisone- adrenal suppression
4. antilymphocyte globin*-leukopenia, thrombocytopenia
5. OKT3-serum sickness

*(the “a”’s cause blood issues (leukopenia and thrombocytopenia) but “an” causes anemia)