Oral Surgery Test Review Flashcards
The following are associated with the extracellular space:
- Na+
- K+
- Cl-
Na+
Is there more?
The following are associated with the Intracellular space:
- Na+
- Cl-
- K+
Cl-
and
K+
??????
_______ _______ is where local anesthesia exert their pharmacological actions
Nerve membrane
______ ______ ______: Local anesthesia bind to specific receptor on the
Na channel
SPECIFIC RECEPTOR theory
Nodes of Ranvier: Sodium channel is_______.
abundant
How Local Anesthesia Work?
• Decrease permeability of ion channels to Na
• Nerve block by local anesthesia is a
Non-depolarizing block
T/F: nerves have a quicker conduction than un-myelinated. AND….
Adelta and A Alpha (about 120 m/sec) are faster than C fibers (1.2 m/sec) .
true
Where does local anesthesia work at myelinated nerve?
the nodes of ranvier
Is local anesthesia hydrophilic or they like oily stuff?
Hydrophillic (injectable)
t/f: only the free base form of LA can diffuse through the wall of the nerve.
true
t/f:
↑ pKa translate to slow onset
true
t/f:
↓ pKa will have faster onset
true
t/f: Extracellular pH determines the ease for nerve blockade
true:
So, since: RNH = RN+H+
does the higher pH (more H+ shift the equation to RNH which cannot cross neerve membrane like free base can. This results in less effective LA?
t/f:
Greater lipid solubility relates to intrinsic potency
true – Nerve membrane is 90% lipid
t/f:
Increased protein binding will increase duration
true – Nerve membrane is 10% protein
Lipid Solubility influences: _______
potency
pKA influences: _______
onset
Protein Binding influences: ________
Duration
↑ Tolerance to drug after repeated administration
Tachyphylaxis
what are the Different classes of local anesthesia
Ester and Amide
______ most potent vasodilator
Procaine
_______ : the only local anesthetic with constrictor effect
Cocaine
_____ ______ has greatest % of anesthetics
Skeletal muscle
How do you calculate elimination half life?
Time needed for 50% reduction in blood level
- 1st t ½ 50%
- 2nd t ½ 75%
- 3rd t ½ 87.5%
- 4th t ½ 94 %