Oral surgery Flashcards
3 effects of aspirin
Analgesic
(COX-1 & 2 inhibition, reduces prostaglandin synthesis)
Antipyretic
(prevents temperature raising effects of IL-1 - reduces elevated temperature in fever)
Anti-inflammatory
(reduced prostaglandin synthesis as prostaglandin is vasodilator which affects capillary permeability)
4 adverse effects of aspirin
GIT problems - ↑ gastric acid secretion, ↓ blood flow through gastric mucosa, ↓ mucin production & cytoprotective action
Hypersensitivity
Overdose - tinnitus, metabolic acidosis
Aspirin burns on mucosa
Groups to avoid/ caution prescribing aspirin to (14)
- Peptic ulceration
- Gastric pain
- Bleeding abnormalities
- Anticoagulant users
- Steroid users
- Renal/ hepatic impairment
- < 16 yrs
- Asthmatics
- Hypersensitivity to other NSAIDS
- Using other NSAIDS
- Elderly
- Pregnant women
- Nephrotoxicity
- G6PD-deficiency
4 absolute contraindications of prescribing aspirin
- Lactating women
- Children below 16 (Reye’s syndrome)
- Haemophilia
- Hypersensitivity to aspirin or other NSAIDS
Prescription of aspirin
300mg 2 tablets qid after food, 5 days
For odontogenic pain
Maximum adult dose of ibuprofen
2.4g
Groups to caution when prescribing ibuprofen (8)
- Active/ previous peptic ulceration
- Asthmatics
- Taking other NSAIDS
- NSAID hypersensitivity
- Pregnancy/ lactation
- Renal/ cardiac/ hepatic impairment
- Patients on long term systemic steroids
- Elderly
3 adverse effects of ibuprofen
- GI discomfort
- Hypersensitivity reactions
- Headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, tinnitus… (see BNF)
For patients taking antihypertensive drugs, how many days should the regimen of ibuprofen be restricted to?
5 days or less
3 symptoms of ibuprofen overdose + management
Symptoms:
- nausea
- vomiting
- tinnitus
Management: Activated charcoal if more than 400 mg/kg ingested within the last hour
Prescription of paracetamol
500mg 2 tablets qid 5 days
For odontogenic pain
Mode of action of paracetamol
Indirect inhibition of COX pathway by blocking positive feedback action of hydroperoxides
3 groups to caution when prescribing paracetamol
- Hepatic impairment
- Renal impairment
- Alcohol dependance
4 (rare) side effects of paracetamol
- Rashes
- Blood disorders
- Hypotension
- Liver damage following overdose (less frequently kidney damage)
What is considered a therapeutic excess of paracetamol? (2)
More than 8g in 24 hours (recommended adult daily dose) and > 75 mg/kg
What amount/ level of paracetamol may cause severe hepatocellular necrosis?
150 mg/kg
Management of paracetamol overdose
Refer to A&E for assessment
Considerations for flap design
- Wide based
- No sharp angles
- Adequate side (size does not affect healing)
- Avoid dental papillae
1 advantage & 1 disadvantage of polyfilament sutures
Advantage
- Easy to handle
Disadvantage
- Prone to wicking, draws bacteria and can result in infection
3 advantages & 1 disadvantage of monofilament sutures
Advantages
- Passes easily through tissue
- Resistant to bacterial colonisation
- Causes less scarring
Disadvantage
- Slippery and difficult to handle
Advantages of ZOE as retrograde sealant for periradicular surgery (4)
- Cheap
- Easy to use
- Radiopaque
- Bacteriostatic
Disadvantages of ZOE as retrograde sealant for periradicular surgery (3)
- Sensitive to moisture
- May resorb
- Doesn’t promote cementogenesis
Advantages of MTA as retrograde sealant for periradicular surgery (3)
- Moisture resistant
- Promotes cementogenesis
- Very good seal
Disadvantages of MTA as retrograde sealant for periradicular surgery (3)
- Expensive
- Long setting time
- Difficult to use
Failed endodontic treatment
- Obstruction to instrumentation
-> Calcification
-> Broken instrument
-> Dilaceration
-> Root #
- Root filler error/ problem
-> Underfilled
-> Overfilled
-> Open apex - Post crown treated tooth
- Lateral perforation
- Radicular cysts/ other pathology
Causes of failure of periradicular surgery (3)
- Inadequate seal
- Inadequate support
- Miscellaneous: longitudinal root split, poor healing response, exposure of root apex
Name a monofilament & multifilament resorbable & non resorbable suture (4)
Resorbable
Monofilament - Monocryl
Multifilament - Vicryl Rapide
Non resorbable
Monofilament - Prolene
Multifilament - Mersilk
How to manage fractures of alveolar bone during XLA
- If bone completely removed from tooth socket with tooth, do not replace
- Smooth sharp edges w bone file/ rongeurs and reapproximate soft tissues
- If bone still attached to periosteum, dissect bone with soft tissue away from tooth by stabilising tooth with forceps and separating using periosteal elevator
- Reapproximate bone and soft tissues and secure with sutures
Management of jaw fractures during XLA
- Explain to patient what happened + provide reassurance
- Provide analgesia
- Fast patient
- AB (PenV/ met/ equivalent)
- Phone OMFS
List 8 immediate postoperative complications
- Pain
- Swelling
- Ecchymosis
- Trismus (limited mouth opening)
- Dry socket
- Infected socket
- Haemorhage (post-op bleeding)
- Prolonged effects of nerve damage
4 causes of post-extraction trismus?
- IDB
- prolonged mouth opening
- spasming of muscles from fibrosis following haematoma
- oedema and joint effusion in TMJ
How can post extraction trismus be managed?
Using trismus screws/ wooden tongue depressors
Classification of dental procedures that are likely to cause bleeding - LOW RISK of post op bleeding complications
- Simple extraction of 1-3 teeth
- Incision & drainage of IO swelling
- Full mouth 6PPC
- Subgingival PMPR
- Direct/ indirect restorations with subgingival margins
Classification of dental procedures that are likely to cause bleeding - HIGHER RISK of post op bleeding complications
- Complex extractions/ extractions of >3 teeth at once
- Flap raising procedures:
– Surgical extractions
– Periodontal surgery
– Preprosthetic surgery
– Periradicular surgery
– Crown lengthening
– Implant surgery - Gingival recontouring
- Biopsies
4 examples of DOAC + MOA of DOACs
- Apixaban - direct oral factor Xa inhibitor
- Dabigatran - direct oral thrombin inhibitor
- Rivaroxaban - direct oral factor Xa inhibitor
- Edoxaban - direct oral factor Xa inhibitor
How to manage patients requiring dental procedures with/ without bleeding risks taking:
1. Apixaban
2. Dabigatran
3. Rivaroxaban
4. Edoxaban
- Apixaban & dabigatran -> miss morning dose, resume night time dose
- Rivaroxaban & edoxaban -> delay morning dose & take 4 hours after haemostasis achieved OR take as usual in the evening
4 additional precautions for patients taking DOACs
- Stage extensive/ complex procedures
- Treat early in the day
- Limit initial tx area & assess bleeding before continuing
- Haemostatic measures - packing & suture
3 groups of patients where anticoagulant/ antiplatelet therapy should NOT be interrupted
- Prosthetic metal heart valves/ coronary stents
- PE/ DVT in last 3 months
- Cardioversion
3 examples of vitamin K antagonist (coumarins)
- Warfarin
- Acenocoumarol
- Phenindione
Briefly describe MOA of warfarin
- Vitamin K antagonist
- Vitamin K used to produce clot factors
- Inhibits vitamin K epoxide reductase
- Which is an enzyme which reduces and activates vitamin K
- Depletes functional vitamin K reserve
- ↓ active clot factor synthesis
- ↑ blood clotting time
How should a patient taking Warfarin be managed
- Check INR ideally no more than 24 hours before procedure
- If INR levels stable and <4, treat without interrupting medication
- Stage tx, limit initial tx area & assess bleeding, suture & pack
- If INR > 4, delay invasive tx & refer if urgent
3 examples of injectable anticoagulants
- Deltaparin
- Enoxaparin
- Tinzaparin
Management of patients taking injectable anticoagulants
- Low prophylactic dose - treat without interrupting medication
- Treatment (higher dose) - consult prescribing clinician
4 examples of antiplatelet drugs
- Aspirin
- Clopidogrel
- Dipyridamole
- Prasugrel
- Ticagrelor single/ dual therapy
Management of patients taking antiplatelet drugs
Treat without interrupting medication
5 local haemostatic agents that can be used to manage postoperative bleeding
- LA with vasoconstrictor
- Surgicel (oxidised regenerated cellulose)
- Haemocollagen sponge
- Thrombin liquid & powder
- Floseal
5 systemic haemostatic aids to manage post operative bleeding
- LA with vasoconstrictor
- Tranexamic mouthwash/ tablets
- Blood clotting factors
- Plasma/ whole blood
- Desmopressin - DDAVP
Management of post-operative bleeding (8)
- Reassure/ calm patient and carer
- Firm pressure with gauze on site while taking quick history
- Remove jelly like clot
- LA with vasoconstrictor
- Pack with surgicel/ bone wax and suture
- Ligate vessels/ diathermy if available
- Post op instructions
Post op instructions to prevent post op bleeding (5)
- No hot food
- Avoid traumatising with tongue/ brushing
- No strenuous activity
- Spitting on first day and avoid excessive rinsing following days
- No excess alcohol
For how long can you expect improvement from nerve damage up to?
18 months
3 types of sensory change that can occur after nerve damage (clinical description)
- Anaesthesia (numbness)
- Paraesthesia (tingling)
- Dysaesthesia (abnormal sensation)
Anatomical descriptions of nerve damage
- Neuropraxia - contusion of nerve, epineural sheath and axons continuity maintained
- Axonotmesis - axons continuity maintained but epineural sheath disrupted
- Neurotmesis - complete loss of nerve continuity
Symptoms of dry socket
- Pain 3-4 days after XLA
- Worse pain than right after XLA
- Throbbing pain radiates to ear, keeps awake at night
- Bad taste, smell
Predisposing factors for dry socket
- Molars
- Mandible
- Difficult XLA
- Women
- OCP use
- Smoking
Management of dry socket
- Irrigate socket with saline
- Inspect for bony sequestrum
- Dress with alvogyl
- HSMW
Predisposing factors for osteomyelitis
- Odontogenic infections
- Fractures of the mandible
- Compromised host defence
– Diabetes
– Alcoholism
– IV drug use
– Malnutrition
– Myeloproliferative disease (leukemias, sickle cell disease, chemotherapy treated cancer)
Clinical signs of osteomyelitis
- Pyrexia
- Extraction site tender
- Altered sensation to lower lip & chin (pressure on IAN)
+/- pus in chronic infections - More common in mandible
Radiographic signs of osteomyelitis
- Acute suppurative lesions show little to no change
- Chronic osteomyelitis
– Bony destruction
– “Moth eaten appearance”
– Bony sequestrum, involucrum
Bacteria involved in osteomyelitis
- Streptococci (streptococcus anginosus)
- Peptostreptococcus
- Fusobacterium
- Prevotella
Ix for osteomyelitis
- Swabs & culture + sensitivity testing
- Bloods & glucose testing
Surgical management of osteomyelitis
- Drain pus
- Remove non vital teeth in area of infection
- Remove loose pieces of bone
- (Referral to OS/ OMFS)
- In fractured mandible remove wires, plates, screws in area
- Corticotomy
- Excise necrotic bone, until actively bleeding bone tissue reached
Non surgical management of OM
AB therapy (penicillins)
- 6 weeks after symptoms resolve - acute
- Up to 6 months - chronic
- IV if systemic and symptoms
How to prevent ORN
- Scaling/ CHX MR leading up to XLA
- Atraumatic XLA technique
- Antibiotics, CHX MR & review
- Hyperbaric oxygen b4 & after XLA
- Seek advice/ refer for XLA
Management of ORN
- Remove loose sequestrate
- Irrigate necrotic debris
- Antibiotics if 2ry infection
- In severe cases resect exposed bone, margin of unexposed bone, soft tissue closure
- Hyperbaric oxygen
MRONJ incidence in
- Cancer patients
- Osteoporosis patients
- Cancer patients <5% (5 in 100)
- Osteoporosis <0.05% (5 in 10,000)
3 types of drugs that can cause MRONJ & 2 examples of each
- Antiresorptive/ bisphosphonates
– Alendronate
– Zoledronate - RANK-L inhibitors
– Denosumab - Antiangiogenic
– Monoclonal antibodies
— Bevacizumab
— Aflibercept
– Tyrosine kinase inhibitor
— Sunitinib
— Sorafenib
Risk factors for MRONJ (3)
- Dental treatment
– Mucosal trauma from dentures
– Dental infection
– Untreated periodontal disease - Duration of bisphosphonate drug therapy (longer duration higher risk)
- Other concurrent medication
– Systemic glucocorticoids
– Bisphosphonates + anti-angiogenic drugs
Should the following groups of patients get implants? How should they be managed?
- High dose anti-resorptive/ anti-angiogenic drugs for management of cancer
- Osteoporosis patients taking bisphosphonates
- Avoid implants for patients being treated with high dose anti-resorptive/ anti-angiogenic drugs for management of cancer
- Not contraindicated. Warn patients about
compromised healing at implant site
increased risk of MRONJ
advise how to minimise risk (good OH)
When should a patient who is treated with six monthly subcutaneous injections of denosumab have dental treatment done?
- 1 month before next cycle due
- Monitor for healing before resuming
Patient risk categories for MRONJ
- Low risk
- High risk
- Low risk
- Bisphosphonate use for osteoporosis
<5 yrs
- No concurrent systemic glucocorticoid use - High risk
- Bisphosphonate use for >5 years
- Concurrent use of systemic glucocorticoids
- Antiresorptive +/ antiangiogenic drugs for management of cancer
- Previous MRONJ