Oral Mucosa Flashcards

Question

Oral mucosa - Langerhans Cells - what is it? Location? Derivatives? Chemokines? Movement through body? Granules? Interactions? Functions?

Answer 1

Characterisitics: - dendritic cells and APCs Location: - above basal cell layer Derivatives: - of bone marrow precursor, they leave blood stream and enter lamina propria before penetrating stratum germinativum Chemokines: - secreted by keratinocytes act as chemotactic agent Movement: - from local lynoh nodes via dermal lymphatic Granules: - birbeck granules (rod shaped) Interaction: - with T lympho Functions: - contact hypersensitivity reaction of skin - anti-tumour immunity - grant rejection - propagator of HIV1 transmission to T cells

Answer 2

``` Found: - in basal cell layers, close to nerve fibres and common in masticatory mucosa but absent in mucosa lining Role: - receptor Derivatives: - neural crest CK specific: - CK8/18 and 20 Organelles: - deeply invag nucleus, nuclear rodlet, mito, free ribo and granules and vesicles adj to nerve ```

Answer 3

2 parts: - superficial papillary layer (loose thin Col fibres) - deep reticular layers (thick parallel collagen bundles) Compsition: - fibroblasts and immune cells ECM: - Col I 90% and Col III 8% - small non-fibrillar collagen, elastin and oxytalan - proteoglycans and glycoprots

Answer 4

Name: - basal lamina Composition: - fibrils and ground substance 2 zones: - lamina lucida, found immediately under epith - lamina densa (fibroreticular lamina) Synth: - by epithelial cells - lamina lucida made of laminin Laminin: - cements type IV Col between the lamina densa and epith cells Lamina densa: - made of Col IV coated with heparan sulphate - fibronectin found and bind fibroblast and proteoglycan Linkage: - thick Col fibre attached to lamina densa to link basal lamina to CT

Answer 5

Rolle: - provide mechanical adhesion between epith and CT - molecular barrier - response to injury

Answer 6

What is it: - layer of loose fatty or glandular CT Contains: - major BVs and nerves supplying the mucosa and separating it from the underlying bones and muscles Compsition: - determines the flexibility of the mucosal attachment to underlying structures - minor salubery glands and serous and sebaceous present (rarelt) - nodes of lymphoid tissue also be seen

Answer 7

Masticatory oral mucosa Lining oral mucosa Specialised mucosae

Answer 8

``` Subjected to: - high compression and friction Covers: - the hard palate and the gingiva Epith: - keratinsied Lamina propria is thick ```

Answer 9

``` Subjected to: - no high friction Special function: - mobile and distensible Covers: - lips, cheeks, alveolar mucosa, soft palate, ventral surface of tongue and floor of the mouth Epith: - non-kerat Loose lamina propria ```

Answer 10

Located: - dorsal surface of tongue - lingual tonsils - gingival attachment to the teeth - vermilion border

Answer 11

``` Mucosa: - skin on outer surface and labial mucosa on inner side Vermilion: - zone in between (transition zone, red) Muscles: - striated muscles in lip core Glands: - minor salivary gland in submucosa ```

Answer 12

Keratinised epidermis and CT dermis Hair follicles Sebaceous glands and sweat glands

Answer 13

- No skin appendages - Occasional sebaceous glands, but no mucous glands - Keratinised - Lamina propria has capillary loop - Red appearance clinically - junctional region between the vermilion zone and the labial mucosa is the intermediate zone - parakaratinsed - infants becomes thickened and forms suckling pad

Answer 14

``` Epith: - thick non-kerat epith Lamina: - wide with short and irregular papilla Submucosa: - many minor salivary glands CT fibres: - dense bind the mucosa to the orbicularis oris muscle ```

Answer 15

``` Located: - buccal mucosa Epith type: - lining mucosa Keratinised: - non-kerat with dense lamina propria Submucosa: - many minor salivary Muscle: - buccinator muscle beneath glands Line: - linea alba buccalis (kerat line in the buccal mucosa along occlusal plane) Ectopic gland: - sebaceous (Fordyce's granules) ```

Answer 16

What is it: - the portion of the oral mucosa that surrounds and is attached to the teeth 2 main regions: - the attached gingiva (directly bound to the underlying bone and tooth) - the free gingiva (narrow, not bound to any bone) The free gingival groove demarcates the free from the attached gingiva (40% of teeth)

Answer 17

``` Anatomy: - JE - enamel space - sulcular epith - gingival epith - gingival lig - alveolodental lig - alveolar crest Gingival margin: - is the coronal limit of the free gingiva Gingival sulcus: - the unattached region between the free gingiva and the tooth JE: - area where the gingiva is bound to the tooth Free gingival groove: - follows contours of the CEJ Principal fibres: - running from cementum to gingiva Healthy: - shows stippling, corresponding to epith ridges ```

Answer 18

``` External surface: - is masticatory mucosa - keratinised epith variation 75%: - parakeratinised Characteristics: - rete ridges - mucoperiosteum ```

Answer 19

``` What is it: - identical to attached gingiva Sulcus: - 0.5-2.0 is healthy Depth: - greater than 3.0mm is considered a perio pocket ```

Answer 20

``` Form: - sulcular and JE form the gingival cuff Compared: - more folded interface CK: - different profiles Character: - thin and non-kerat Base: - sulcus at same level as free gingival groove ```

Answer 21

``` What is it: - junctional epithelium extends from CEJ to the sulcus base (2mm) Thinner - apically 2 layers: - stratum basale and spinosum Turnover rate: - 5/6 days 2 basal laminae: - interal (adj to enamel) and external (adj to lamina propria) Lamina densa: - internal lamina not clearly delineated (lacks Col IV and laminin) ```

Answer 22

``` Spaces: - smaller number of desmosomes result in space (5% of tissue vol) Fluid: - crevicular fluid and immune cells pass through spaces Length: - varies with the stage of eruption On erupt: - most of enamel covered by JE Later lon: - JE and CEJ Recession: - apical mig and contact with cementum ```

Answer 23

Seal environ: - dentogingival junction seals lamina propria from oral environment Location: - within sulcus, results from the permeability of the JE Course: - pass from the lamina propria into the sulcus Function: - important for defence mech

Answer 24

Location: - interdental gingiva occupies area between adj teeth Shape and size: - depend on contact point - wedge shaped appearance on buccal and lingual Between: - anterior teeth Interdental Col: - a curved depression across the buccolingual plane FIlls: - the contour around the contact point

Answer 25

``` Col: - epith of col continuous with the JE Non-keratinised Spaced teeth: - no col, have thin keratinised gingiva instead ```

Answer 26

``` Fibroblasts: - lack alkaline phosphatase - less contractile prots, ground sub, Col III Turnover: - lower Rich in: - vasc, 2 plexi beneath the oral SE and beneath GE Histamin: - release more prostaglandin Dense Col bundles: - support fee gingiva - bind attached gingiva to alveolar bone and tooth - lankage to adj teeth Principal fibres: - divided into groups on location ```

Answer 27

``` Dentogingival Longitudinal Circular Alveologingival Dentoperiosteal Transseptal Semicircular Transgingival Interdental Vertical Oblique Apical Interradicular ```

Answer 28

What is it: - attached gingiva is demarcated from the alveolar mucosa by the mucogingival junction Location: - 3-5mm below the alveolar crest Characteristics: - non-kerat, loose submucosa (elaston), BVs near surface and minor salivary Attached to: - submucosa attached to periosteum

Answer 29

``` Mucosa type: - masticatory Epith type: - keratinised Submucosa: - none present especially centrally - exists where the palate meets the alveolus (contains main neurovascular bundle) Nasal surface: - lined with respiratory epith - ciliated columnar epith with goblet cells Type of submucosa: - vascular submucosa with minor glands ```

Answer 30

``` Epith type: - non keratinised Histo description: - short broad CT papillae submucosa: - with many salivary glands ```

Answer 31

FoM and ventral tongue lining: - both the floor of the mouth and the ventral surface of the tongue have a typical lining mucosa Function: - need for mobility Epith type: - thin, non keratinised epithelium with short papillae Submucosa: - submucosa considerable for the floor of the mouth, but almost absent for the ventral surface of the tongue Lamina propria: - highly vasc (drug route)

Answer 32

``` Split: - anterior 2/3 are divided from the post 1/3 by sulcus terminalis Cover 2/3: - covered with papillae Has lots 1/3: - lymphatic nodules Types of papillae: - filiform, fungiform, foliate and circumvallate Filiform: - largely cover the ant 2/3 of dorsum tongue Kerat: - yes (para or ortho) Central core: - of lamina propria with 2nd papillae branch Function: - highly abrasive (mechanical) ```

Answer 33

``` Fungiform: - found as isolated elevated mushroom shaped papillae between filiform Size: - 150-400um Epith type: - kerat or non-kerat Core: - vasc lamina propria also found: - taste buds on surface ```

Answer 34

Foliate: - may be found as 1-2 longitudinal clefts at the side of the posterior part of the tongue Epith type: - non-kerat Other found: - taste buds maybe found within their epithelium

Answer 35

``` Size: - large and rounded surrounded by: - trench like structures projection: - not beyond surface of tongue Epith type: - non-kerat other found: - taste buds on lateral wall of trenches ```

Answer 36

``` Von Ebner's - serous gland Empty into: - base of trenches Mucous glands also present ```

Answer 37

``` What is it: - a chemoreceptive organ of taste Types: - circumvallate, fungiform and foliate Opening: - small pore opens from surface into bud types of cells: - tase and supporting cells Sensory cell types: - I (appear dark) - II (appear light) - III (appear light) - IV (are undiff, lay basally and possess intermediate filaments) I and III: - form synapses with intrageminal nerves Separate: - basal lamina separates bud from lamina propria ```

Answer 38

What are they: - masses of lymphoid tissue on the lateral border of the posterior third of the tongue Part of: - Waldeyer's ring (lingual, palatine and pharyn) Deep crypts: - lined with epith containing masses of lymphoid tissue Gland: - mucous gland