Oral Mucosa Flashcards
what are the 2 basic tissues of oral mucosa
epithelium - superficial
CT - underlying
what protection does mucosa have
mechanical
chemical
bacterial
prevent dehydration
is the mucosa innervated and involved in sec
richly innervated
secretion
what are some features of mucosa
free gingiva attached gingiva alveolar mucosa mucogingival junction free gingival groove
where can masticatory mucosa be found
roof of mouth
gingiva upper and lower infant and behind teeth
where can lining mucosa be found
inside lips and sulci
posterior mouth - tonsils
ventral aspect tongue
where is some specialised mucosa
dorsum tongue
what si the structure of non keratinised lining mucosa
epithelium
lamina propria
submucosa
bone or muscle
what are imp features of non keratinised lining mucosa
undulating interface LP
rete pegs
no muscular mucosae
flexible
what does the epithelium layer of non keratinised lining mucosa consist of
superficial layer
intermediate layer
prickl cell layer
basal cell layer
why is the prickle cell layer calls
when fixation shrinks but still attached at desmosome attachments between cells
is the epi replaced
turnover v quick
all the time
what do al epi cells have
filaments
desmosomes
what is a feature of basal cells -
least differentiated
mitosis often visible
what do prickle cells contain
membrane coating granules
MCGs
what do the intermediate cell layer contain
MCGs discharge between cells
(GOO - waterproof) perm barriernd wholly effective
why is it clinical important
drug abs
what are in superficial layer cells
flattened cells
nuclei persist
not dehydrated therefore flexible
what is the structure of keratinised masticatory mucosa
epi rete pegs lamina proppria - papillary layer - reticular layer periosteum bone
what are some imp features of keratinised masticatory mucosa
many rte pegs no submucosa LP firm attach to bone resist compression relative immobile and mech tough
LA into lining mucosa
flexible
can be pain free if done properly
LA into masticatory mucosa
tightly bound can hurt
what is the structure of keratinised mucosa
keratinised layer
granular
prickle cell
basal cell
what do basal cells like
non keratinsied epi
what are the filaments in prickle cells organise into
bundles
tonofibrils
wat are the granular cell layer cells
keratohyaline
assc wth tonofibirls
filaggrin - form matrix for filaments in keratinised layer
in the granular cell layer what do the MCGs do
discharge contents sealing cells together
effective perm barrier
cells beyond barrier zone are dehydrate
what are thee keratinised layer cells like
flattened cells squames
no organelle
contain filled with keratin
dehydrated and not flexible
what is parakertainsiation
incomplete removal of organelles form the superficial layers
nuclei shrunk - pyknotic
what is the epi turnover
5 days - junc epi
10-14 days- cheek
mast mucosa slower
rapid heal process
what are some epi abnormalities
acanthosis
acanholysis
what is acanthosis
hyperplasia of prickle cell layer - pcoriasis
what is acanttholysis
disruption of intercellular connections
pemphigus
how many cells in epi non keratinocytes
10%
what do non keratinocytes lack
tonofibrils and desmosomes
what are some examples of non kertancytes
merkel cols
melanocytes
langerhanns cells
inflammatory cells
why call non keratinocytes called clear cells
light microscopic appearance
when fix seething what happens
it shrinks
what is a merkel cell
touch receptor link to nerves
what is a melanocyte
dense melanosomes
melanin
pigmentation
where are Merkel cells and melanocytes in epi
in basal layer
in supra basal layer have what non pertained cells
langerhnns
inflam cells
what are langerhanns cells
more superficial layers
dendritic
process antigenic material
what are the inflammatory cell
transiently migrate into epi
lymphocytes common
what does the lamina propria contain
is CT
collagen
- 90% type 1
- 8% type 2
fibroblasts
defence cells
where is lamina propria loose
papillary layer
where is lamina propria more organise
reticular layer
what are some sensory innervations in CT
free nerve endings
krause end bulbs
ruffini corpuscles
wha are some sensory innervation in epi
free nerve endings
merkel cells - neurone complexes
what are the two layers of basal lamina
lamina lucida
- thick
- glycoprotein laminin
lamina densa
- thick
- type 4 collagen
what re some features of basal lamina
basal cell hemi-desmosomes lamina lucida lamina densa anchoring filaments collagen fibrils anchoring fibrils
why is there a large surface interface area
disperses applied forces
metabolic interchange
