Immunisation Against Dental Caries Flashcards
what is natural immunity
active - natural recovery
passive - maternal Ab
what is artificial acquired immunity
passive immunisation
active vaccinations
what does saliva contain
sIgA IgG IgM Leukocytes C3
what sin gingival crevicular fluid
IgG IgM complement PMLN's lymphocytes (B and T) Macrophages
what is a vaccination
admin of material of microbial origin to a susceptible person to swim immune defences
what does vaccination do
tim long last protection against a sp disease
what is the Bowen exp
live cariogenic strain s mutans into IV monkey with cariogenic diet
stim IgA
are IgG levels sp
yes
what are antigens/adhesins of s mutans
LTA polysacc protein cell wall cell imm glucosyl transferase peptidoglycan gluten binding portion
what are some sucrose indent attachment
protein antigens 1/2
what are some sucrose dept reaction
GTFS
what is the lehner idea
immunise with purified protein
streptococcal antigen I/II
what did passive immunisation show in lehner
monoclonal Ab against antigen I/II
what does this passive immunisation of lehner do
applied topically to tooth
dental caries slim
high levels s mutant and dental caries controlled
what are GTF used for by s mutans
accumulation
what do protein antigens do for s mutans
attachment to pellicle
what do GBP do for s mutans
phase III
what is the pre/clinical trials for antigen I/II
surface adhesion
block receptor for attach of pellicle
how is antigen I/II given
subcutaneous inject
passive admin
what do 2 GTFs do
make sol and inso glucans
what is the structure of GTF
n terminus - 2 catalytic domains
c terminus - GBP
what do MAP peptides do
inhibit GTF activity
protect ag caries
what do surface proteins do GBP
bind glucans prod by catalytic enzymes
what does Gbps immunisation do
protect rats
reduced s mutans
what is the conv of MAP to GTF & GbpB
enhances immunogenicity
extended effect of s sobrinus
what does s sobrinus GTF + water sol glucans do
preclinical caries reduction
what does GTF + antigen I/II do
inhibit s mutans adhere
suppress s mutans colonise
what does di epitaphic GTF MAP
reduce caries preclinical
what does di epitopic GTF & GbpB MAP do
reduce caries
what does active passive immunisation
elliot antibodies
- immunological mem
- sp
what si passive immunisation
expo to antibodies
- safe
- monoclonal
- transgenic plant
- egg yolk
how is he ID of best antigenic material
combination antigens
more than one target
how is admin of vaccine
loca
intrnasal
tonsilaar
what is the timing of passive immunisation
12 months
before colonisation and immuocompetetent
what are some alternative approaches of controlling caries
fluorination topical fluoride sealants brush, floss dietary
