Immunisation Against Dental Caries

Question 1

what is natural immunity

Answer 1

active - natural recovery

passive - maternal Ab

Question 2

what is artificial acquired immunity

Answer 2

passive immunisation

active vaccinations

Question 3

what does saliva contain

Answer 3

sIgA 
IgG
IgM 
Leukocytes
C3

Question 4

what sin gingival crevicular fluid

Answer 4

IgG 
IgM 
complement 
PMLN's
lymphocytes (B and T) 
Macrophages

Question 5

what is a vaccination

Answer 5

admin of material of microbial origin to a susceptible person to swim immune defences

Question 6

what does vaccination do

Answer 6

tim long last protection against a sp disease

Question 7

what is the Bowen exp

Answer 7

live cariogenic strain s mutans into IV monkey with cariogenic diet
stim IgA

Question 8

are IgG levels sp

Answer 8

yes

Question 9

what are antigens/adhesins of s mutans

Answer 9

LTA
polysacc
protein 
cell wall
cell imm 
glucosyl transferase
peptidoglycan
gluten binding portion

Question 10

what are some sucrose indent attachment

Answer 10

protein antigens 1/2

Question 11

what are some sucrose dept reaction

Answer 11

GTFS

Question 12

what is the lehner idea

Answer 12

immunise with purified protein

streptococcal antigen I/II

Question 13

what did passive immunisation show in lehner

Answer 13

monoclonal Ab against antigen I/II

Question 14

what does this passive immunisation of lehner do

Answer 14

applied topically to tooth
dental caries slim
high levels s mutant and dental caries controlled

Question 15

what are GTF used for by s mutans

Answer 15

accumulation

Question 16

what do protein antigens do for s mutans

Answer 16

attachment to pellicle

Question 17

what do GBP do for s mutans

Answer 17

phase III

Question 18

what is the pre/clinical trials for antigen I/II

Answer 18

surface adhesion

block receptor for attach of pellicle

Question 19

how is antigen I/II given

Answer 19

subcutaneous inject

passive admin

Question 20

what do 2 GTFs do

Answer 20

make sol and inso glucans

Question 21

what is the structure of GTF

Answer 21

n terminus - 2 catalytic domains

c terminus - GBP

Question 22

what do MAP peptides do

Answer 22

inhibit GTF activity

protect ag caries

Question 23

what do surface proteins do GBP

Answer 23

bind glucans prod by catalytic enzymes

Question 24

what does Gbps immunisation do

Answer 24

protect rats

reduced s mutans

Question 25

what is the conv of MAP to GTF & GbpB

Answer 25

enhances immunogenicity

extended effect of s sobrinus

Question 26

what does s sobrinus GTF + water sol glucans do

Answer 26

preclinical caries reduction

Question 27

what does GTF + antigen I/II do

Answer 27

inhibit s mutans adhere

suppress s mutans colonise

Question 28

what does di epitaphic GTF MAP

Answer 28

reduce caries preclinical

Question 29

what does di epitopic GTF & GbpB MAP do

Answer 29

reduce caries

Question 30

what does active passive immunisation

Answer 30

elliot antibodies

• immunological mem
• sp

Question 31

what si passive immunisation

Answer 31

expo to antibodies

• safe
• monoclonal
• transgenic plant
• egg yolk

Question 32

how is he ID of best antigenic material

Answer 32

combination antigens

more than one target

Question 33

how is admin of vaccine

Answer 33

loca
intrnasal
tonsilaar

Question 34

what is the timing of passive immunisation

Answer 34

12 months

before colonisation and immuocompetetent

Question 35

what are some alternative approaches of controlling caries

Answer 35

fluorination 
topical fluoride
sealants
brush, floss
dietary