Oral Medicine Flashcards
In “mesenchymal stromal cell therapy for FCGS: long term experience” by soltero-rivera, et al, in frontiers 2023
What was the overall success rate? How many experienced permanent improvement or cure?
65.5%
58.6%
In “mesenchymal stromal cell therapy for FCGS: long term experience” by soltero-rivera, et al, in frontiers 2023
What % experienced adverse effects? What were they?
34.2%
Transient transfusion-like reactions
Note - more common in autologous (69.2% of reactions) vs allogenic (30.8%)
In “mesenchymal stromal cell therapy for FCGS: long term experience” by soltero-rivera, et al, in frontiers 2023
Was there any correlation between allogenic and autologous MSC, severity of SDAI at entry or exit, or delta between SDAI at entry and exit?
No
In “mesenchymal stromal cell therapy for FCGS: long term experience” by soltero-rivera, et al, in frontiers 2023
What was a predictor of long term response?
Status 6 months post therapy
In “mesenchymal stromal cell therapy for FCGS: long term experience” by soltero-rivera, et al, in frontiers 2023
What % experienced transient improvement?
17.2%
In “mesenchymal stromal cell therapy for FCGS: long term experience” by soltero-rivera, et al, in frontiers 2023
What % experienced no improvement at any time following treatment?
24%
In “feline FCGS current concepts in clinical management” by soltero-rivera, et al in JFMS 2023
What pro-inflammatory cytokines are more likely to have increased expression in FCGS cats?
IFN gamma, TNF alpha, IL-1beta, and IL-6
In “ histological, immunological, and genetic analysis of feline, chronic gingivostomatitis” by vapniarski, Simpson, and arzi in frontiers 2020
What was demonstrated for the first time?
Systemic dysregulation of CD8 effector memory and central memory cells - cats with FCGS have higher circulating CD8+ effector memory cells with concurrent decrease in central memory cells and evidence of circulating activated CD8+ T cells
In “ use of unbiased metagenomic and transcriptomic analysis to investigate the association between feline calicivirus and feline chronic gingivostomatitis and domestic cats” by fried, soltero-rivera, et al in Am J Vet area 2021
What was the only microbe strongly associated with FCGS? Any association between its presence and response to treatment?
FCV - 94% of FCGS affected cats and no control cats
No association
In “ use of unbiased metagenomic and transcriptomic analysis to investigate the association between feline calicivirus and feline chronic gingivostomatitis and domestic cats” by fried, soltero-rivera, et al in Am J Vet area 2021
What virus was significantly more abundant in cats with refractory FCGS than cats with responsive FCGS?
Puma feline foamy virus - found in 9/13 refractory cats and 5 healthy cats, but in none of the FCGS cats that responded to extractions
In “ use of unbiased metagenomic and transcriptomic analysis to investigate the association between feline calicivirus and feline chronic gingivostomatitis and domestic cats” by fried, soltero-rivera, et al in Am J Vet area 2021
What were there 2 conclusions?
Many FCV strains may yield false negative results on RT-PCR based assays
Coinfection with FCV and puma feline foamy virus may affect response to treatment
In “ a case series, analysis of dental extractions outcome in cats with FCGS carrying retroviral disease” by Silva, Mestrinho, et al, in Animals 2021
What % of cats without retroviral disease experienced significant improvement after dental extractions? FeLV+? FIV+?
What was statistically significant?
Healthy - 90%
FIV - 79.3%, not statistically significantly different vs control
FeLV - 54.5%, statistically significantly worse
In “ a case series, analysis of dental extractions outcome in cats with FCGS carrying retroviral disease” by Silva, Mestrinho, et al, in Animals 2021
Independent of retroviral status, what was associated with a worse response to dental extractions?
Lingual ulcers - cats with lingual ulcers were 2.7x more prone to have a worse response than cats w/o lingual ulcers
