Oral Med Flashcards

1
Q

3 herpes group viruses associated with intraoral vesiculation?

A

Herpes simplex virus 1 and 2

Epstein -Barr virus

Varcella Zoster virus

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2
Q

Name 2 oral mucosal diseases caused by COXSACKIE virus?

A

Hand, foot and mouth

Herpangina - mouth blisters

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3
Q

Name 2 oral diseases that are caused by Esptein- Barr virus?

A

Glandular fever

Hairy leukoplakia

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4
Q

Which caranial nerve does herpes simplex become residant to on the lower lip - nerve and branch?

A

Mandibular branch of the trigeminal nerve.

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5
Q

What is mucostis?

A

inflammation and ulceration caused by chemo and radio

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6
Q

What is the percent of oral candidosis ppresnet in cancer patients?

A

47-87%

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7
Q

How do you access cancer?

A

Early detection of cancer (Screening)

Assessment of identified cancer (Staging) may include biopsy

Planning cancer treatment (Radiotherapy)

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8
Q

What are the types of cancer treatment?

A

Surgical –most effective for small encapsulated tumors(clear margins reduce recurrance)

-remove complete tumor, may also remove regional lymph nodes if suspicious of spead

Chemotherapy –kill tumor cells without harming host- rarely possible

Radiotherapy – ionising radiation damage to cellular DNA has to be delivered over time due to different cell dividing times thus moderate to high dose to overlying tissue

Combination Treatments

Palliative Therapy

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9
Q

What are the signs of histopathological changes in cancer?

A

Loss of polarity

Dysplasia

Mitoctic cells

Loss of basal membrane

Pleomorphism of cell and nucli

Epithelium cell nest (keratin pearl)

Hypochromatism of neculi

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10
Q

What are the causes of ulceration?

A

Trauma

Idiopathic

Allergies

Drug induced

Nutritional deficiencies

Immunologica

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11
Q

What percentage of leukoplakia may become malignent?

A

0.2-4%

Erythroplakia- less common but higher malignancy rate

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12
Q

What percent of oral malignancies are squamous cell carcinomas?

A

more then 90%

  • tobacco- smoking or smokeless tobacco
  • betel quid (chewing habits)
  • alcohol (acetaldehyde)
  • diet and nutrition
  • oral hygiene
  • viruses HPV HSV EBV HHV-8
  • Immunodeficiency
  • socioeconomic factors
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13
Q

What are the most common sites for oral cancer?

A

floor of mouth - 45%

soft palate- 25%

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14
Q

What is a virus?

A

a microscopic entity consisting of a single nucleic acid surrounded by a proteint coat and is only able to replicate within a living thing

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15
Q

What are the 5 stages of viral replication?`

A

Adsorption-Virus recognizes and attaches to specific host cell. Spikes on envelope attach or proteins on capsule match receptors on host cell

Penetration-Virus taken into cell by endocytosis or viral envelope fuses with host cell membrane and dumps content into host cell

Replication-Viral genes are copied within minutes and mass produced into viral parts

Assembly-Individual viral parts are assembled into a whole virus

Release- New active viruses are released from host cell

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16
Q

What are the characteristics of kaposis sarcama accosiated herpes virus?

A
  • vascular tumor
  • Associated with AIDS
  • latrogenic (organ transplant patients)
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17
Q

What is oral mucosa comprised of ?

A
  • Stratisfied squamous epithelium

- lamina propria (loose connective tissue)

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18
Q

What are the 3 type of of oral mucosa?

A
  • lining non-keritinised dark mucosaa(buccal, floor of mouth, soft palate)
  • masticatory keratinised dark mucosa (hard palate, gingivae and tongue)
  • gustatory mucosa(areas of the tongue where taste buds are
19
Q

What are the two types of keratinised tissue?

A
  • Orthokeratosis

- Parakeratosis

20
Q

What are the possible reactions in the epithelium?

A
  • keratosis
  • atrophy
  • erosion
  • ulceration
  • oedena
  • blisters
21
Q

What are the different types of lichen planus?

A

-desquamative gingivitis
-Bullous
-reticular
-papular
-plaque like
-erosive
atrophic

22
Q

What is dysplasia?

A

the disordered/abnormal growth in a tissue

  • which is only diagnosed histologically not clinically

Mild- observe and re-biopsy
moderate- rmove
severe- remove

23
Q

What is atypia?

A

change in cells - only diagnosed via histo and not clinically

24
Q

How does an iron deficiancy affect the oral cavity?

A
  • person is predispositioned to infection (Oral candidosis is common)
  • loss of papillae pattern
  • atrophy of the tongue
25
Q

How does Vit B12 deficiencies affect the oral cavity ?

A
  • Macroglossia
  • Burning mouth syndrome
  • geographic tongue
26
Q

How does a folate deficiency affect the oral cavity?

A
  • macroglossia

- geographic tongue

27
Q

how would a vit C deficiency affect the oral cavity ?

A

gingival scurvy

Vit C is required fr cross-linking during connective tissue which causes non-repair of the mucosa

28
Q

What are fordyce spots?

A

inactive sebaceous glands

29
Q

What is smokers keratosis?

A

dark areas of the palate caused by melanin production which leaks into the connective tissue and is then engulfed with macrophages

30
Q

What is the likeliness that smokers will have leukoplakia?

A

6 times more likely

31
Q

What is frictional keratosis?

A

caused by bruxism

32
Q

What is lichen planus?

A

an autoimmune condition which has has no known cause but lichenoid reactions with a known cause

  • oral cases linked with 10-30% or skin lesions
  • skin cases linked with 50% of oral cases
33
Q

HOw would you differentiate between lichen planus and lupus erythmatous?

A

lupus erythamatous can be found on the palate and thus rules out lichen planus .

(Red with white striae)`

34
Q

What is the definitionn of congenital?

A

diseases, defects or deformaties from birth without being hereditary

35
Q

What acquired cinditions may be developmental ?

A
  • Infective
  • Trauma
  • neoplastic
36
Q

What are the types of fibrous lesions?

A

REACTIVE-

  • fiberous overgrowth
  • hyperplasia
  • fibro-epithelial polyp
  • Fibromatosis
  • Neoplasms
37
Q

What types of fiberous overgrowth is present in denture wearers?

A

-denture induced hyperplasia
-leaf fibroma
papillary hyperplasia of the palate

38
Q

What are the difference between tori and osteomas?

A

osteomas increase in size and have symptoms, tori do not

39
Q

What are the types of mucosal neoplasms?

A
  • benign- squamous cell papilloma (wart of HPV)
  • Malignant - squamous cell carcinoma
  • Epithelial
  • connective tissue
  • vascular - kaposis sarcoma
40
Q

What is granulation tissue?

A

is fibro-vascular new tissue with microscopic blood vessels which form on the surface of the wound during the healing process which groows from the base of a wound

41
Q

What is OFG??

A

a condition which there is lymphatic obstruction from giant cell granulomatis which causes accumulation of tissue fluid with resulting oedema. Linked with chrones and sarcoidosis disease

42
Q

what is seen histologically process in OFG?

A
  • giant cell formation
  • increased tissue fluid produced due to inflammation
  • lyphatic obstruction
43
Q

What are the common causes of ulceration in the mouth?

A

Trauma (heals within 2 weeks when cause is removed)

Immunological

  • Recurrent aphthous ulcers
  • Lichen planus
  • Lupus
  • Vesiculo-bulbous
  • Erythema multiforme

Carcinoma

Infections

  • Bacterial
  • Viral
  • Fungal

Gastrointestinal

  • Crohn’s disease
  • Ulcerative colitis

Drugs related
-Nicorandil – angina pectoris vasodilator drug

44
Q

What are the types of recurrent oral ulceration?

A

Categories:

  • Minor
  • Major
  • Herpetiform
  • Behçet’s syndrome

Non-aphthous

  • Traumatic ulceration e.g. orthodontic appliance rubbing
  • Lichen planus

Vesiculo-bulbous diseases

  • Pemphigoid
  • Pemphigus
  • Angina bullosa haemorrhagica

Viral infections