Oral Med Flashcards
3 herpes group viruses associated with intraoral vesiculation?
Herpes simplex virus 1 and 2
Epstein -Barr virus
Varcella Zoster virus
Name 2 oral mucosal diseases caused by COXSACKIE virus?
Hand, foot and mouth
Herpangina - mouth blisters
Name 2 oral diseases that are caused by Esptein- Barr virus?
Glandular fever
Hairy leukoplakia
Which caranial nerve does herpes simplex become residant to on the lower lip - nerve and branch?
Mandibular branch of the trigeminal nerve.
What is mucostis?
inflammation and ulceration caused by chemo and radio
What is the percent of oral candidosis ppresnet in cancer patients?
47-87%
How do you access cancer?
Early detection of cancer (Screening)
Assessment of identified cancer (Staging) may include biopsy
Planning cancer treatment (Radiotherapy)
What are the types of cancer treatment?
Surgical –most effective for small encapsulated tumors(clear margins reduce recurrance)
-remove complete tumor, may also remove regional lymph nodes if suspicious of spead
Chemotherapy –kill tumor cells without harming host- rarely possible
Radiotherapy – ionising radiation damage to cellular DNA has to be delivered over time due to different cell dividing times thus moderate to high dose to overlying tissue
Combination Treatments
Palliative Therapy
What are the signs of histopathological changes in cancer?
Loss of polarity
Dysplasia
Mitoctic cells
Loss of basal membrane
Pleomorphism of cell and nucli
Epithelium cell nest (keratin pearl)
Hypochromatism of neculi
What are the causes of ulceration?
Trauma
Idiopathic
Allergies
Drug induced
Nutritional deficiencies
Immunologica
What percentage of leukoplakia may become malignent?
0.2-4%
Erythroplakia- less common but higher malignancy rate
What percent of oral malignancies are squamous cell carcinomas?
more then 90%
- tobacco- smoking or smokeless tobacco
- betel quid (chewing habits)
- alcohol (acetaldehyde)
- diet and nutrition
- oral hygiene
- viruses HPV HSV EBV HHV-8
- Immunodeficiency
- socioeconomic factors
What are the most common sites for oral cancer?
floor of mouth - 45%
soft palate- 25%
What is a virus?
a microscopic entity consisting of a single nucleic acid surrounded by a proteint coat and is only able to replicate within a living thing
What are the 5 stages of viral replication?`
Adsorption-Virus recognizes and attaches to specific host cell. Spikes on envelope attach or proteins on capsule match receptors on host cell
Penetration-Virus taken into cell by endocytosis or viral envelope fuses with host cell membrane and dumps content into host cell
Replication-Viral genes are copied within minutes and mass produced into viral parts
Assembly-Individual viral parts are assembled into a whole virus
Release- New active viruses are released from host cell
What are the characteristics of kaposis sarcama accosiated herpes virus?
- vascular tumor
- Associated with AIDS
- latrogenic (organ transplant patients)
What is oral mucosa comprised of ?
- Stratisfied squamous epithelium
- lamina propria (loose connective tissue)