oral hormonal Flashcards
What can contraceptives be used for aside from preventing pregnancies
Menstrual cycle regulation
Reduction of premenstrual symptoms
Tx of acne
What are the Estrogen contraceptives
Ethinyl estradiol
Mestranol (prodrug of above)
What are the Progestin contraceptives? Rank from highest to lowest androgenic activity
Levonorgestrel and Norgestrel
Norethindrone
Desogestrel and Norgestimate
Drospirenone (anti-androgenic)
What are the non-hormonal contraceptives
Barrier
IUD
Sterilization
What are the combined oral contraceptives
Monophasic
Biphasic
Triphasic
What is in Monophasic
Fixed dose in each pill
What is in Biphasic and Triphasic
Variable proportions of each hormone
How do combined oral contraceptives work
Suppress FSH and LH (prevent ovulation)
How does Progestin act
Thickens cervical mucus
Impairs implantation
How do you limit AE of oral combined contraceptives
Low doses
What do combined oral contraceptives have a protective effect over
Endometrial/Ovarian CA Benign breast disease Ovarian cysts PID Acne
What is the most common combined oral contraceptive cycle
21 active 7 placebo
What are the most common AE of combined oral contraceptives
Nausea, bloating
Breakthrough bleeding
What are the most notable AE of combined oral contraceptives
Hirsuitism Oily skin Acne Melasma Amenorrhea Dyslipidemia
What is the CVD effect of combined oral contraceptives
Increased VIII and fibrinogen
What are the main combined oral contraceptives contraindications
Thromboembolic disease
Stroke,CAD BreastCA,
estrogendependentneoplasm Hepatictumorsorliverdisease Abnormaluterinebleeding Heavysmokingover 35
What are the minor contraindications for combined oral contraceptives contraindications
Migraine HTN Diabetes Fibroids Breast feeding Smoking
What do you not want to give with combined oral contraceptives contraindications
P450 inducers
Broad spectrum ABx - Rifampin
