Oral DM meds

Question 1

TZDs examples

Answer 1

Pioglitizone (actos) Rosiglitizone (avandia)

Question 2

TZD black box warning

Answer 2

CHF: May cause or worsen CHF Monitor for edema and weight gain

Question 3

TZD AE

Answer 3

Weight gain: peripheral fracture risk

Question 4

Drug that can interact and cause low BG esp with Sulfonylureas and meglitinide

Answer 4

aspirin, cimetidine, ethanol, fluonazole, saicylates, allopurinol, vitamin K, steroids, sulfonimides, MAO inhibitors

Question 5

Drugs that can increase BG

Answer 5

niacin, OCP, Pancreatic enzymes, protease inhibitors

fibrates, tacrolimus, Thyroid drugs, cyclosporine, NSAIDS, Isoniazid, corticosteroids, disopyramide, diuretics,

Question 6

Glyburide and metformin can increase BG when used with_______

Answer 6

Acarbose and Miglitol

Question 7

Drugs that may increase or decrease BG

Answer 7

Betar adrenergic drugs, Cholestyramine,

Etoh, Fluoxetine, Rifampin, phenothiazines

Question 8

Sulfonylureas

Answer 8

Glimiperide (Amaryl) Glipizide (glucotrol) Glyburide (diabetes/glynase/micronase)

Question 9

Meglitinides

Answer 9

Nateglinide (starlix) Repaglinide (Prandin)

Question 10

Biguanides

Answer 10

Metformin (glucophage and glucophagexr)and Riomet (liquid) Fortamet

Question 11

Alpha Glucosidase Inhibitors

Answer 11

Miglitol (glyset) or Acarbose (Precose)

Question 12

Dopamine receptor agonist

Answer 12

Bromocriptine (cycloset)

Question 13

SGL2 Inhibitors

Answer 13

Canagliflozin (Invokana), Empagliflozin( Jardiance),

dapagliflozin (Farxiga) * INcrease DKA risk!

Question 14

AE with SGLT2 inhibitors

Answer 14

mycotic infections, UTI, hypotension Bladder CA with Dapagliflozin) Hyperkalemia with Canagliflozin

Question 15

SE of DPP 4 inhibitors

Answer 15

URI, UTI, headache

Question 16

___ & ___ decrease risk of death from CV dz

Answer 16

Empagliflozin and Canagliflozin Jardiance and Invokana

Question 17

Metformin don’t use if GFR < ____

Answer 17

30

Question 18

For dye study with metformin____

Answer 18

stop metformin prior to study; restart 48 hours after

Question 19

Which drugs can increase DKA risk?

Answer 19

SGLT-2 inhibitors, diuretics, beta blockers, steroids, Aniti psychotics and anti convulsants