Oral DM meds Flashcards
TZDs examples
Pioglitizone (actos) Rosiglitizone (avandia)
TZD black box warning
CHF: May cause or worsen CHF Monitor for edema and weight gain
TZD AE
Weight gain: peripheral fracture risk
Drug that can interact and cause low BG esp with Sulfonylureas and meglitinide
aspirin, cimetidine, ethanol, fluonazole, saicylates, allopurinol, vitamin K, steroids, sulfonimides, MAO inhibitors
Drugs that can increase BG
niacin, OCP, Pancreatic enzymes, protease inhibitors
fibrates, tacrolimus, Thyroid drugs, cyclosporine, NSAIDS, Isoniazid, corticosteroids, disopyramide, diuretics,
Glyburide and metformin can increase BG when used with_______
Acarbose and Miglitol
Drugs that may increase or decrease BG
Betar adrenergic drugs, Cholestyramine,
Etoh, Fluoxetine, Rifampin, phenothiazines
Sulfonylureas
Glimiperide (Amaryl) Glipizide (glucotrol) Glyburide (diabetes/glynase/micronase)
Meglitinides
Nateglinide (starlix) Repaglinide (Prandin)
Biguanides
Metformin (glucophage and glucophagexr)and Riomet (liquid) Fortamet
Alpha Glucosidase Inhibitors
Miglitol (glyset) or Acarbose (Precose)
Dopamine receptor agonist
Bromocriptine (cycloset)
SGL2 Inhibitors
Canagliflozin (Invokana), Empagliflozin( Jardiance),
dapagliflozin (Farxiga) * INcrease DKA risk!
AE with SGLT2 inhibitors
mycotic infections, UTI, hypotension Bladder CA with Dapagliflozin) Hyperkalemia with Canagliflozin
SE of DPP 4 inhibitors
URI, UTI, headache
___ & ___ decrease risk of death from CV dz
Empagliflozin and Canagliflozin Jardiance and Invokana
Metformin don’t use if GFR < ____
30
For dye study with metformin____
stop metformin prior to study; restart 48 hours after
Which drugs can increase DKA risk?
SGLT-2 inhibitors, diuretics, beta blockers, steroids, Aniti psychotics and anti convulsants
