Oral Complications Associated with Radiation and Chemotherapy Flashcards
Cancer
Definition
An abnormal growth of cells which tend
to proliferate in an uncontrolled way
and, in some cases, to metastasize
(spread).
— million people living with cancer
Approx. – million male
Approx. – million female
11.7
5.4
6.3
– million people diagnosed with cancer every year
Approx. – male
Approx. – female
1.5
760,000
740,000
— diagnosed with oral cavity or pharynx cancer
every year
– men vs. – women
– with oral cancer
– tongue cancer
– pharynx cancer
36,540
25,000
11,000
11,000
11,000
12,000
Head and Neck Cancers make up –% of all cancers
– most common cancer in men
Not in the top – for women
3
8th
10
Squamous Cell Carcinoma
2 Areas
Oral Cavity
Oropharynx
The Oral Cavity
(6)
Gingiva
Floor of the Mouth
Anterior portion of the Tongue
Buccal Mucosa
Hard Palate
Teeth
Oral Cavity SCC
Risk Factors
(6)
Smoking
Alcohol
Smokeless tobacco
Marijuana
Betel quid (India and SE Asia)
Chronic irritation
Decreased – use has has a
significant effect on the incidence of SSC in the oral
cavity
alcohol and tobacco
–% decrease every year from 1973-2004 for non-HPV
related oral cavity SSC
1.9
The survival rates of oral cavity non-HPV SSC has not
improved dramatically
In 1999, the 5 year survival rate for oral cavity cancer
was
Men – –%
Women – –%
48
55
Why the Poor Survival Rate?
(3)
LATE DETECTION
Proximity to the cervical lymph nodes
The oral SCC may be a metastatic lesion and not the
primary
The Oropharynx
(4)
Soft palate
Tonsils
- Lingual
- Palatine
Base of the tongue
Pharynx
- Lateral
- Posterior
Oropharyngeal SCC Risk Factors
(3)
Human Papilloma Virus (HPV)
Alcohol
Tobacco
The Human Papilloma Virus
– million Americans infected (14 million per year)
79
HPV
Over – types
– subtypes
40
120
HPV (2) associated with oropharyngeal SSC
16 and 18