Oral Complications Associated with Radiation and Chemotherapy Flashcards

1
Q

Cancer
Definition

A

 An abnormal growth of cells which tend
to proliferate in an uncontrolled way
and, in some cases, to metastasize
(spread).

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2
Q

— million people living with cancer
 Approx. – million male
 Approx. – million female

A

11.7
5.4
6.3

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3
Q

– million people diagnosed with cancer every year
 Approx. – male
 Approx. – female

A

1.5
760,000
740,000

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4
Q

— diagnosed with oral cavity or pharynx cancer
every year
 – men vs. – women
 – with oral cancer
 – tongue cancer
 – pharynx cancer

A

36,540
25,000
11,000

11,000
11,000
12,000

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5
Q

 Head and Neck Cancers make up –% of all cancers
 – most common cancer in men
 Not in the top – for women

A

3
8th
10

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6
Q

Squamous Cell Carcinoma
2 Areas

A

 Oral Cavity
 Oropharynx

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7
Q

The Oral Cavity
(6)

A

 Gingiva
 Floor of the Mouth
 Anterior portion of the Tongue
 Buccal Mucosa
 Hard Palate
 Teeth

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8
Q

Oral Cavity SCC
Risk Factors
(6)

A

 Smoking
 Alcohol
 Smokeless tobacco
 Marijuana
 Betel quid (India and SE Asia)
 Chronic irritation

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9
Q

Decreased – use has has a
significant effect on the incidence of SSC in the oral
cavity

A

alcohol and tobacco

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10
Q

–% decrease every year from 1973-2004 for non-HPV
related oral cavity SSC

A

1.9

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11
Q

The survival rates of oral cavity non-HPV SSC has not
improved dramatically
 In 1999, the 5 year survival rate for oral cavity cancer
was
 Men – –%
 Women – –%

A

48
55

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12
Q

Why the Poor Survival Rate?
(3)

A

 LATE DETECTION
 Proximity to the cervical lymph nodes
 The oral SCC may be a metastatic lesion and not the
primary

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13
Q

The Oropharynx
(4)

A

 Soft palate
 Tonsils
- Lingual
- Palatine
 Base of the tongue
 Pharynx
- Lateral
- Posterior

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14
Q

Oropharyngeal SCC Risk Factors
(3)

A

 Human Papilloma Virus (HPV)
 Alcohol
 Tobacco

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15
Q

The Human Papilloma Virus
– million Americans infected (14 million per year)

A

79

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16
Q

HPV
Over – types
 – subtypes

A

40
120

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17
Q

HPV (2) associated with oropharyngeal SSC

A

16 and 18

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18
Q

Over – men and – women diagnosed with HPV-
positive SSC yearly

A

9000
2300

19
Q

Getting Tested

A

 OraRisk HPV Testing
- Rinse with saline and expectorate
 What information is provided?

20
Q

HPV Positive SCC
(3)

A

 E6 and E7 oncoprotiens from HPV dysregulate the
function of tumor suppressor genes (P53 and pRB)
 Non-keratinized lesions with minimal or no epithelial
dysplasia
 Lobular growth

21
Q

The Good News on HPV-Associated
Oropharyngeal SCC
(2)

A

 Highly responsive to radiation and chemotherapy
 2 year survival rate
 HPV-positive – 94%
 HPV-negative – 58%
 Preventable

22
Q

HPV Vaccinations
(2)

A

Guardasil
Cervarix

23
Q

Guardasil
(3)

A

 HPV 6, 11, 16, 18
 Available to boys and girls
 3 injections over 6 months

24
Q

Cervarix
(3)

A

 HPV 16 and 18
 Available to girls only
 3 injections over 6 months

25
Q

In 1973, oropharyngeal cancers accounted for 18% of
all head and neck cancers, now it accounts for 31%
 —% annual increase for base of the tongue SCC (1973-
2004)
 —% annual increase for tonsillar SCC (1973-2004)

A

1.3
0.6

26
Q

Why the shift from the oral cavity to
the oropharynx?
(2)

A

 Widespread education on the ills of smoking and
alcohol
 Changes in sexual behavior
- Increase in the number of sexual partners
- Oral sex

27
Q

The Bad News On HPV Associated
Oropharyngeal SCC
Onset
 Significant long term oral issues related to —

A

 Early Onset
 40-59 yoa
radiation
therapy

28
Q

The Six Step Oral Cancer Screening

A

 Tongue ‘n Gauze
 Lip & Cheek Roll
 Double-Digit Probe
 Palate Tickle
 Neck Caress
 Tonsil Ahhhhhhhh

29
Q

Adjunctive aids
(4)

A

 Vital Tissue Staining
 Transepithelial Brush Test
 Tissue Auto fluorescence
 Tissue Reflectance (chemiluminescence)

30
Q

Vital Tissue Staining
(4)

A

 Toluidine blue
 Pre and post rinse with 1% acetic acid
 TB stains acidic components of the cells
 Dysplastic tissues contain increased levels of nucleic
acids (increased cell replication)
Vital Tissue Staining

31
Q

Transepithelial Brush test
(2)

A

 OralCDx test
 Press the brush on the suspect areas and rotate until
bleeding occurs

32
Q

OralCDx Report
 Positive:
 Atypical:
 Negative:

A

Dysplasia or carcinoma
Abnormal changes
Normal epithelium

33
Q

Tissue Auto fluorescence
(2)

A

 VELscope
 Utilizes blue excitation light (430 nM)

34
Q

 Utilizes blue excitation light (430 nM)
Based on the absorptive and reflective pattern of
— in the tissue
 Components of cellular metabolism
(2)

A

fluorophores

 Nicotine adenine dinucleotide
 Flavin adenine dinucleotide

35
Q

“Other Dark Spots”
(6)

A

 Lichen planus
 Migratory glossitis
 Amalgam tattoos
 Racial pigmentation
 Traumatic fibroma
 Nicotine stomatitis

36
Q

Tissue Reflectance
(Chemiluminescence)
(2)

A

 Orascoptic DK
 MicroLux/DL

37
Q

Tissue reflectance

A

Rapid replication of DNA in pre-cancerous and
cancerous lesions results in large nuclei that occupy a
majority of the cell and reflect white light

38
Q

Tissue Reflectance
(3)

A

 Rinse with 1% acetic acid
 Illuminate with blue-white light
- 440 nM
 Suspect lesions are “acetowhite”

39
Q

Tissue Reflectance
ViziLite Tblue
(4)

A

 Rinse with 1% acetic acid
 Evaluate with blue-white light
 Mark suspect lesions with Tblue
 Re-evaluate under normal light

40
Q

Identafi 3000
Provides – different wavelengths of light

A

3

41
Q

Provides 3 different wavelengths of light

A

 White light
 Violet light-excited fluorescence (405 nM)
 Green-amber reflected light

42
Q

 White light

A

 Conventional oral examination

43
Q

 Violet light-excited fluorescence (405 nM)

A

 Same concept as Velscope auto-fluorescence

44
Q

 Green-amber reflected light

A

 Hemoglobin absorb the light and present as dark areas
 Normal – delineated blood vessels
 Abnormal – disorganized “fuzzy” appearance